Kyle A. Powell

发表

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.

R. Neitz, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.

R. Neitz, H. Sham, T. Yednock, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.

G. Tóth, R. Neitz, H. Sham, 2010, Bioorganic & medicinal chemistry letters.

α2β1 and αVβ1 integrin signaling pathways mediate amyloid-β-induced neurotoxicity

R. Rydel, T. Yednock, S. Wright, 2007, Neurobiology of Aging.

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

G. Tóth, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System*S⃞

Normand L. Frigon, R. Motter, H. Sham, 2009, Journal of Biological Chemistry.

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.

John-Michael Sauer, Zhao Ren, Dean R Artis, 2011, Bioorganic & medicinal chemistry letters.

Nucleation-Dependent Polymerization Is an Essential Component of Amyloid-Mediated Neuronal Cell Death

R. Rydel, M. Wogulis, S. Wright, 2005, The Journal of Neuroscience.

Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicity.

R. Rydel, T. Yednock, S. Wright, 2007, Neurobiology of aging.