H. Stein

发表

Discovery of a well-absorbed, efficacious renin inhibitor, A-74273.

P. Kovar, H. Kleinert, J. Polakowski, 1992, Hypertension.

Cardiovascular Effects and Hemodynamic Mechanism of Action of the Novel, Nonpeptidic Renin Inhibitor A‐74273 in Dogs

P. Kovar, H. Kleinert, J. Wessale, 1993, Journal of cardiovascular pharmacology.

Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation.

D. Garvey, S. Rosenberg, W. Shen, 1998, Bioorganic & medicinal chemistry letters.

The measurement by a microtitration technique of carbon dioxide production in rat brain slices. Studis with glucose, fructose, and xylitol.

J. Cohen, H. Stein, 1976, Analytical biochemistry.

Modified peptides which display potent and specific inhibition of human renin.

P. Marcotte, J. Plattner, H. Kleinert, 1987, Biochemical and biophysical research communications.

Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors.

S. Rosenberg, B. Dayton, W. Baker, 1992, Clinical chemistry.

New inhibitors of human renin that contain novel Leu-Val replacements.

J. Plattner, J. Cohen, J. Luly, 1987, Journal of medicinal chemistry.

New inhibitors of renin that contain novel phosphostatine Leu-Val replacements.

R. Maki, K. Marsh, J. Plattner, 1990, Journal of medicinal chemistry.

Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement.

R. Maki, J. Plattner, H. Kleinert, 1987, Journal of medicinal chemistry.

Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site.

S. Rosenberg, P. Marcotte, J. Plattner, 1987, Journal of medicinal chemistry.

Discovery of a peptide-based renin inhibitor with oral bioavailability and efficacy.

P. Kovar, S. Rosenberg, H. Kleinert, 1992, Science.

Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency.

D. Egan, P. Marcotte, H. Kleinert, 1988, Journal of medicinal chemistry.

New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site.

J. Greer, G. Bolis, J. Plattner, 1988, Journal of medicinal chemistry.

Design of a well-absorbed renin inhibitor.

D. Egan, S. Rosenberg, H. Kleinert, 1991, Journal of medicinal chemistry.

Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond.

D. Kempf, J. Plattner, J. Cohen, 1987, Journal of medicinal chemistry.

1,2,3-trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors.

S. Rosenberg, R. Austin, W. Baker, 1992, Journal of medicinal chemistry.

The determination of sulfhydryl groups in reduced hair keratin

H. Stein, Julia Guarnaccio, 1960 .

Infrared Study of Oxidized Keratin

H. Stein, Julia Guarnaccio, 1959 .

Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.

S. Fesik, J. Greer, H. Sham, 1988, Journal of medicinal chemistry.

C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties.

D. Egan, W. Baker, J. Cohen, 1992, Journal of medicinal chemistry.

Modification of the 5' position of purine nucleosides. 1. Synthesis and biological properties of alkyladenosine-5'-carboxylates.

K. Tietje, H. Stein, A. Fung, 1976, Journal of medicinal chemistry.

Intraocular pressure lowering effects of the renin inhibitor ABBOTT-64662 diacetate in animals.

H. Kleinert, C. Wismer, W. J. Giardina, 1990, Journal of ocular pharmacology.

Renin inhibitors: C-terminal oxetanes as potent transition-state mimics.

S. Rosenberg, H. Kleinert, W. Baker, 1994, Bioorganic & medicinal chemistry.

CARDIOVASCULAR EFFECTS OF NUCLEOSIDE ANALOGS

P. Somani, H. Stein, R. Prasad, 1975, Annals of the New York Academy of Sciences.

Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides.

R. Egan, K. Tietje, H. Stein, 1980, Journal of medicinal chemistry.

Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides.

D. Egan, S. Rosenberg, J. Polakowski, 1993, Journal of medicinal chemistry.

Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-7251

P. Kovar, S. Rosenberg, J. Polakowski, 1993, Journal of medicinal chemistry.

MODIFICATION OF THE 5′ POSITION OF PURINE NUCLEOSIDES. 1. SYNTHESIS AND BIOLOGICAL PROPERTIES OF ALKYL ADENOSINE‐5′‐CARBOXYLATES

K. Tietje, H. Stein, A. Fung, 1977 .

Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog.

J. Wessale, K. Verburg, W. Baker, 1994, Journal of medicinal chemistry.

Slow, tight binding to human renin of some nonpeptidic renin inhibitors containing a 4‐methoxymethoxypiperidinylamide at the P4 position

S. Rosenberg, B. Dayton, H. Kleinert, 1992, FEBS letters.

ORALLY BIOAVAILABLE PEPTIDELIKE MOLECULES : A CASE HISTORY

H. Kleinert, W. Baker, H. Stein, 1993 .

Highly potent and specific inhibitors of human renin

H. Sham, J. Plattner, H. Stein, 1987, FEBS letters.

Peptide analogues of angiotensinogen. Effect of peptide chain length on renin inhibition.

J. Greer, H. Sham, J. Plattner, 1986, Biochemical and biophysical research communications.

Pemoline and Magnesium Hydroxide: Lack of Effect on RNA and Protein Synthesis

T. Yellin, H. Stein, 1967, Science.

8-substituted theophyllines. In vitro inhibition of 3',5'-cyclic adenosine monophosphate phosphodiesterase and pharmacological spectrum in mice.

H. Stein, E. Goodsell, K. J. Wenzke, 1971, Journal of Medicinal Chemistry.

(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.

D. Garvey, S. Rosenberg, S. Fakhoury, 1997, Journal of medicinal chemistry.

Ethyl adenosine-5'-carboxylate. A potent vasoactive agents in the dog.

H. Stein, 1973, Journal of medicinal chemistry.

Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site.

R. Maki, D. Kempf, S. Rosenberg, 1990, Journal of medicinal chemistry.

Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.

J. Greer, P. Marcotte, G. Bolis, 1987, Journal of medicinal chemistry.

MODIFICATION OF THE 5′ POSITION OF PURINE NUCLEOSIDES. 2. SYNTHESIS AND SOME CARDIOVASCULAR PROPERTIES OF ADENOSINE‐5′‐(N‐SUBSTITUTED)CARBOXAMIDES

R. Egan, K. Tietje, H. Stein, 1980 .

Profile of the Renin Inhibitor, Enalkiren (ABBOTT‐64662)

R. Luther, M. Karol, J. Plattner, 1990 .

Study of the effect in vivo of oxotremorine on the activity of choline acetyltransferase (choline acetylase).

J. Cohen, H. Stein, 1970, Biochemical pharmacology.

Studies of binding by macromolecules. A new dialysis technique for obtaining quantitative data.

H. Stein, 1965, Analytical biochemistry.

Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.

J. Greer, H. Sham, P. Marcotte, 1988, Journal of Medicinal Chemistry.

Renin inhibitors Improvements in the stability and biological activity of small peptides containing novel Leu‐Val replacements

P. Marcotte, J. Plattner, H. Kleinert, 1988, FEBS Letters.

Renin inhibitors based on novel dipeptide analogs: Increased efficacy through systematic inclusion of polar functionality

D. Kempf, J. Plattner, H. Kleinert, 1988 .

Conformationally restricted peptide isosteres. 2.1 Synthesis and in vitro potency of dipeptide renin inhibitors employing a 2-alkylsulfonyl-3-phenylcyclopropane carboxamide as a P3 amino acid replacement ☆

Stephen R. Martin, H. Kleinert, W. Baker, 1992 .

Design of rigid heterocyclic phenylalanine replacements for incorporation into renin inhibitors

D. Kempf, J. Plattner, H. Kleinert, 1990 .

Novel statine analogue synthesized from L-aspartic acid

H. Sham, H. Stein, Jerome Cohen, 1987 .

Amide proton exchange rates of a bound pepsin inhibitor determined by isotope-edited proton NMR experiments.

S. Fesik, J. Luly, H. Stein, 1987, Biochemical and biophysical research communications.

Synthesis of 6(S)-amino-7-cyclohexyl-4,4-difluoro-3(R),5(R)-dihydroxy-2-methyiheptane, a novel dipeptide mimic

H. Sham, H. Stein, Jerome Cohen, 1990 .

STUDIES OF ENZYME SYSTEMS UTILIZING AUTOMATED METHODOLOGY

W. R. Roderick, A. Glasky, H. Stein, 1965, Annals of the New York Academy of Sciences.

Studies of acetylcholinesterase utilizing automated methodology.

H. Stein, G. J. Lewis, 1966, Analytical biochemistry.

Isotope-filtered proton NMR experiments for the conformational determination of peptides in solution and bound to biomacromolecules

E. Olejniczak, S. Fesik, R. Gampe, 1988 .