F. Shirai

发表

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.

M. Shirouzu, T. Honma, Hitomi Yuki, 2017, Bioorganic & medicinal chemistry.

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.

T. Umehara, M. Shirouzu, H. Seimiya, 2019, Journal of medicinal chemistry.

Novel tankyrase inhibitors suppress TDP-43 aggregate formation.

A. Kakita, H. Seimiya, K. Wakabayashi, 2020, Biochemical and biophysical research communications.

Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.

A. Tanaka, S. Nagashima, F. Shirai, 2015, Bioorganic & medicinal chemistry.

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

T. Umehara, M. Shirouzu, Y. Shinkai, 2023, Nature Communications.

A New Synthetic Route to the Key Precursor of 1β-Methylcarbapenem Antibiotics from (S)-Methyl 3-Hydroxy-2-methylpropanoate

T. Nakai, F. Shirai, 1989 .

A novel, double-asymmetric aldol approach to the synthesis of a 1β-methyl carbapenem antibiotic precursor

T. Nakai, F. Shirai, 1988 .

A new approach to the chiral synthesis of the 1-.beta.-methylcarbapenem key precursor using an achiral ketone Sn(II) enolate

T. Nakai, F. Shirai, 1987 .

Diastereofacial selection in titanium tetrachloride-promoted aldol reactions with the silyl ketene acetal of methyl (R)-3-hydroxybutanoate.

T. Nakai, F. Shirai, J.‐H. Gu, 1990 .

Epimerization Induced by a Remote Cationic Center in Potent New Carbapenems

T. Chiba, H. Azami, D. Barrett, 1997 .

A New Synthetic Route to the Key Precursor of 1β‐Methylcarbapenem Antibiotics from Methyl (S)‐3‐Hydroxy‐2‐methylpropanoate.

T. Nakai, F. Shirai, 1989 .

A New Approach to the Chiral Synthesis of the 1-β-Methylcarbapenem Key Precursor Using an Achiral Ketone Sn(II) Enolate.

T. Nakai, F. Shirai, 1988 .

1,4-Chirality transfer via the ester enolate Claisen rearrangement

T. Nakai, N. Sayo, F. Shirai, 1984 .

1,4-CHIRALITY TRANSFER VIA THE [2,3]-WITTIG REARRANGEMENT OF CHIRAL ALLYLIC PROPARGYL ETHER SYSTEM. A NEW, PRACTICAL ENTRY TO CHIRAL PROPARGYLIC ALCOHOLS

T. Nakai, N. Sayo, F. Shirai, 1984 .

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems. Part III:

M. Sakurai, T. Kamimura, K. Washizuka, 1999 .

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems Part IV. 2-Alkyl substituents containing cationic heteroaromatics linked via a C-C bond.

M. Sakurai, D. Barrett, A. Tanaka, 2001, Bioorganic & medicinal chemistry.

RK‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model

H. Seimiya, Minoru Yoshida, Yoko Yashiroda, 2018, Cancer science.

Design and Discovery of an Orally Efficacious Spiroindolinone-based Tankyrase Inhibitor for the Treatment of Colon Cancer.

T. Umehara, M. Shirouzu, H. Seimiya, 2020, Journal of medicinal chemistry.

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.

T. Umehara, M. Shirouzu, Minoru Yoshida, 2023, Journal of medicinal chemistry.

Synthesis and properties of 2-alkoxy-N, N-Dimethylethylamine N-oxides

K. Teramura, F. Shirai, Y. Nagano, 1985 .

Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.

S. Schreiber, T. Kapoor, A. Combs, 1996, Chemistry & biology.

Orally active cephalosporins: synthesis, structure-activity relationships and oral absorption of 3-[(E) and (Z)-2-substituted vinyl]-cephalosporins.

A. Ohki, Y. Matsumoto, S. Matsumoto, 2000, Bioorganic & medicinal chemistry.

Exploring the Leucine-Proline Binding Pocket of the Src SH3 Domain Using Structure-Based, Split-Pool Synthesis and Affinity-Based Selection

S. Schreiber, T. Kapoor, J. Morken, 1998 .

Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ1–42 transgenic C. elegans

S. Nishimura, M. Morita, N. Matsuoka, 2009, Brain Research.

FK960 binding proteins, quinone oxidoreductase2 and pyridoxal kinase were identified by LC-MS/MS for drug discovery of Alzheimer's treatment

Z. Tozuka, Y. Ishii, F. Shirai, 2018 .