E. Ohkoshi

发表

Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.

Li Huang, Chin-Ho Chen, K. Lee, 2012, Bioorganic & medicinal chemistry letters.

Bioactivity inspired C19-diterpenoid alkaloids for overcoming multidrug-resistant cancer

H. Yamashita, K. Lee, M. Goto, 2022, Journal of Natural Medicines.

Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.

K. Lee, Ting Zhou, K. Bastow, 2012, Bioorganic & medicinal chemistry letters.

Shikonin induces odontoblastic differentiation of dental pulp stem cells via AKT–mTOR signaling in the presence of CD44

N. Kondoh, Takahisa Ohta, E. Ohkoshi, 2020, bioRxiv.

Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation.

S. Hayakawa, T. Shimizu, N. Nemoto, 2000, Journal of reproductive immunology.

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

E. Ohkoshi, Naoki Umemura, 2016, International journal of oncology.

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents.

K. Lee, S. Morris-Natschke, M. Goto, 2015, Bioorganic & medicinal chemistry letters.

Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents.

K. Lee, S. Morris-Natschke, K. Bastow, 2011, Medicinal chemistry.

A High-Spin Cyanide-Bridged Mn9W6 Cluster (S = 39/2) with a Full-Capped Cubane Structure

A. Fujishima, K. Hashimoto, S. Ohkoshi, 2000 .

Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line.

K. Lee, S. Morris-Natschke, K. Wada, 2012, Bioorganic & medicinal chemistry letters.

Discovery of novel andrographolide derivatives as cytotoxic agents.

K. Lee, H. Hua, Zhiyan Xiao, 2013, Bioorganic & medicinal chemistry letters.

Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44

H. Sakagami, H. Kikuchi, T. Katayama, 2016, Stem Cell Research & Therapy.

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.

Keduo Qian, K. Lee, K. Bastow, 2012, European journal of medicinal chemistry.

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Liying Zhang, Hao Zhu, K. Lee, 2011, Journal of medicinal chemistry.

Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway.

Shuwen Liu, K. Lee, S. Morris-Natschke, 2014, Bioorganic & Medicinal Chemistry.

Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.

Pan‐Chyr Yang, C. Teng, S. Pan, 2012, Journal of medicinal chemistry.

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2015, Bioorganic & medicinal chemistry.

N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin.

Xiao‐Feng Wang, Keduo Qian, K. Lee, 2013, European journal of medicinal chemistry.

Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae).

M. Makino, T. Uchiyama, Y. Fujimoto, 2011, Phytochemistry.

Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

Keduo Qian, K. Lee, S. Morris-Natschke, 2014, Journal of medicinal chemistry.

ent-Kaurenoic acids from Mikania hirsutissima (Compositae).

M. Makino, Y. Fujimoto, E. Ohkoshi, 2004, Phytochemistry.

Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.

K. Lee, M. Goto, K. Bastow, 2012, Journal of medicinal chemistry.

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

A. Oda, K. Lee, E. Hamel, 2016, Bioorganic & medicinal chemistry.

Efficient utilization of licorice root by alkaline extraction.

S. Amano, H. Sakagami, K. Satoh, 2014, In vivo.

Efficient Utilization of Plant Resources by Alkaline Extraction

H. Nakashima, S. Amano, T. Otsuki, 2013 .

A novel bisnorditerpenelactone from Mikania hirsutissima.

M. Makino, Y. Fujimoto, E. Ohkoshi, 2000, Chemical & pharmaceutical bulletin.

Studies on the constituents of the leaves of Baccharis dracunculifolia (Asteraceae) and their cytotoxic activity.

M. Makino, Y. Fujimoto, E. Ohkoshi, 2006, Chemical & pharmaceutical bulletin.

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity.

K. Lee, M. Goto, Kyoko Nakagawa-Goto, 2012, Bioorganic & medicinal chemistry letters.

Antiallergic agent from natural sources. Structures and inhibitory effect of histamine release of naphthopyrone glycosides from seeds of Cassia obtusifolia L.

S. Kitanaka, M. Takido, T. Shibano, 1998, Chemical & pharmaceutical bulletin.

Metastasized murine oral squamous cell carcinoma cells induce intratumoral polymorphonuclear myeloid derived suppressor cells.

H. Kawaki, M. Mizuno-Kamiya, E. Takayama, 2017, Oncology reports.

Synthesis and evaluation of novel podophyllotoxin analogs.

Shipeng Zhang, K. Lee, H. Hua, 2012, Bioorganic & medicinal chemistry letters.

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens.

K. Lee, S. Morris-Natschke, M. Goto, 2012, Bioorganic & medicinal chemistry.

Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice

Shiro Watanabe, Y. Fujii, M. Nagai, 2008 .

Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.

H. Sakagami, J. Shimada, E. Ohkoshi, 2017, Oncology reports.

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring.

A. Oda, K. Lee, E. Hamel, 2015, Journal of medicinal chemistry.

Studies on the constituents of Mikania hirsutissima (Compositae).

M. Makino, Y. Fujimoto, E. Ohkoshi, 1999, Chemical & pharmaceutical bulletin.

Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice.

Aruto Yoshida, K. Shindo, H. Miyazaki, 2007, Planta medica.

Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2013, Bioorganic & medicinal chemistry.

Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.

W. Janzen, M. Hour, Xiao‐Feng Wang, 2012, Bioorganic & medicinal chemistry letters.

Simple preparation of baicalin from Scutellariae Radix.

Y. Fujii, M. Nagai, Hiroyasu Sato, 2009, Journal of chromatography. A.

Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44

H. Sakagami, H. Kikuchi, T. Katayama, 2016, Stem Cell Research & Therapy.

Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives.

K. Lee, Ying-Qian Liu, Liu Yang, 2012, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2016, Bioorganic & medicinal chemistry.

Bioactive components from the heartwood of Pterocarpus santalinus.

Chin‐Chung Wu, Y. Wu, F. Chang, 2011, Bioorganic & medicinal chemistry letters.

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.

Keduo Qian, K. Lee, K. Bastow, 2012, European journal of medicinal chemistry.