J. P. Guare

发表

Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists.

P. Anderson, V. J. Lotti, J. Huff, 1983, Journal of medicinal chemistry.

Design and synthesis of N-alkylated saccharins as selective α-1a adrenergic receptor antagonists☆

R. Chang, Tsing-bau Chen, J. Huff, 1998 .

N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.

P. Anderson, V. J. Lotti, J. Huff, 1985, Journal of medicinal chemistry.

A novel coaxial electrospray ionization method for characterizing hexacosanoylceramides by Fourier transform ion cyclotron resonance mass spectrometry.

H. Ramjit, J. P. Guare, R. Newton, 2005, Rapid communications in mass spectrometry : RCM.

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Mark Embrey, Samson M Jolly, Wei Xu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Linghang Zhuang, D. Hazuda, W. Schleif, 2003, Journal of medicinal chemistry.

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

H. M. Langford, D. Hazuda, W. Schleif, 2000, Journal of medicinal chemistry.

Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors.

M. Holloway, J. Vacca, R. Hungate, 1994, Bioorganic & medicinal chemistry.

Applications of microwave-assisted organic synthesis on the multigram scale.

W. Shipe, C. Lindsley, S. Wolkenberg, 2005, Current opinion in drug discovery & development.

L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.

P. Darke, W. Schleif, J. Quintero, 1994, Journal of medicinal chemistry.

A convergent synthesis of novel conformationally restricted HIV-1 protease inhibitors

J. Vacca, R. Ball, B. Kim, 1994 .

Dibenzocyclooctadiene antileukemic lignan synthesis. (.+-.)-Steganone

R. Wolf, K. Damodaran, G. Krow, 1978 .

Fourier Transform Mass Spectrometry and Nuclear Magnetic Resonance Analysis for the Rapid and Accurate Characterization of Hexacosanoylceramide

M. Bogusky, W. J. Simonsick, C. W. Ross, 2016, International journal of molecular sciences.

[3H]L-654,284 as a probe of the central alpha2 adrenoceptor

J. Huff, J. Vacca, W. Randall, 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

W. M. Sanders, P. Darke, I. Sigal, 1991, Journal of medicinal chemistry.

Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors.

E A Emini, P. Anderson, P. Darke, 1991, Journal of medicinal chemistry.

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

D. Hazuda, J. Shiver, W. Schleif, 2004, Science.

PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination

D. Hazuda, J. Shiver, A. Finnefrock, 2009, The Journal of Immunology.

Novel conformationally constrained HIV-1 protease inhibitors: rational design, enzyme inhibition, and X-ray structure of an enzyme-inhibtor complex

P. Anderson, P. Darke, J. Huff, 1994 .

Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.

S Vickers, R. Freidinger, D. Reiss, 1998, Journal of medicinal chemistry.

Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.

J. Huff, J. Vacca, W. Randall, 1988, Journal of medicinal chemistry.

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

W. M. Sanders, P. Darke, I. Sigal, 1991, Journal of medicinal chemistry.

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

P. Anderson, P. Darke, W. Schleif, 1995 .

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

P. Anderson, P. Darke, W. Schleif, 1994 .

Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.

R. Dixon, P. Darke, C. Leu, 1991, Advances in experimental medicine and biology.

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2006, Bioorganic & medicinal chemistry letters.