Chunlin Zhuang

发表

Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride.

G. Bifulco, W. Gerwick, R. Riccio, 2016, Journal of natural products.

Osteoclastogenesis Inhibitory Polyketides from the Sponge‐Associated Fungus Xylaria feejeensis

Hua Tang, Wen Zhang, K. Soong, 2018, Chemistry & biodiversity.

Swinhoeisterols from the South China Sea Sponge Theonella swinhoei.

A. Mándi, T. Kurtán, Hua Tang, 2018, Journal of natural products.

Immunomodulatory Polyketides from a Phoma-like Fungus Isolated from a Soft Coral.

A. Mándi, T. Kurtán, Hua Tang, 2017, Journal of natural products.

Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea

Hua Tang, P. Sun, Wen Zhang, 2016, Marine drugs.

Briarane Diterpenoids from the Gorgonian Dichotella gemmacea

Hua Tang, P. Sun, Tie-jun Li, 2014, Marine drugs.

Osteoclastogenesis Regulation Metabolites from the Coral-Associated Fungus Pseudallescheria boydii TW-1024-3.

A. Mándi, T. Kurtán, Hua Tang, 2019, Journal of natural products.

Anthraquinone derivatives from a coral associated fungus Stemphylium lycopersici

T. Kurtán, Hua Tang, Wen Zhang, 2019, Natural product research.

Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.

C. Xing, Wannian Zhang, Lijuan Xu, 2019, Journal of medicinal chemistry.

Dietary Flavonoids and Acarbose Synergistically Inhibit α-Glucosidase and Lower Postprandial Blood Glucose.

Z. Xiu, Yuesheng Dong, Y-Q Xing, 2017, Journal of agricultural and food chemistry.

Chalcone: A Privileged Structure in Medicinal Chemistry.

C. Xing, Zhenyuan Miao, Wannian Zhang, 2017, Chemical reviews.

Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice.

Wannian Zhang, Xueqin Ma, Chunlin Zhuang, 2021, Chemico-biological interactions.

Targeting Necroptosis as a Promising Therapy for Alzheimer's Disease.

Lijuan Xu, Zhenyu Cai, Wannian Zhang, 2022, ACS chemical neuroscience.

Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Fen‐er Chen, 2019, European journal of medicinal chemistry.

Structure-based optimizations of a necroptosis inhibitor (SZM594) as novel protective agents of acute lung injury

Wannian Zhang, Lijuan Xu, Zhi-bin Wang, 2021, Chinese Chemical Letters.

Metabolomic profiling of cerebrospinal fluid reveals an early diagnostic model for central nervous system involvement in acute lymphoblastic leukaemia

Jianmin Yang, Y. Chai, Zhenyu Zhu, 2022, British journal of haematology.

Ligand-based design of nondimethylphenyl-diarylpyrimidines with improved metabolic stability, safety and oral pharmacokinetic profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2019, Journal of medicinal chemistry.

Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.

P. Fu, Wannian Zhang, Yin Shi, 2022, European journal of medicinal chemistry.

Structure-based bioisosterism design of thio-benzoxazepinones as novel necroptosis inhibitors.

Wannian Zhang, Lijuan Xu, Chunlin Zhuang, 2021, European journal of medicinal chemistry.

Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy

Congcong Xu, Wannian Zhang, Zhi-bin Wang, 2021, Acta pharmaceutica Sinica. B.

Identification of the Raf kinase inhibitor TAK‐632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3

Hong-Yang Wang, Y. Chai, Xiaofei Chen, 2019, British journal of pharmacology.

Homobivalent, Trivalent, and Covalent PROTACs: Emerging Strategies for Protein Degradation.

Zhenyuan Miao, C. Sheng, Pei Wang, 2022, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors

Shengzhang Wang, Wei Guo, Wenfeng Liu, 2011, Archiv der Pharmazie.

Design, synthesis, and biological evaluation of novel trimethoxyindole derivatives derived from natural products

Xiaodong Zhang, Zhenyuan Miao, Yuelin Wu, 2019, Monatshefte für Chemie - Chemical Monthly.

Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells.

Zhenyuan Miao, Wannian Zhang, Hao Ma, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, European journal of medicinal chemistry.

The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis.

Hong-Yang Wang, Jianqiang Yu, Xiaofei Chen, 2021, Biochemical pharmacology.

Advanced approaches of developing targeted covalent drugs.

Qingjie Zhao, Conghao Gai, C. Cano, 2022, RSC medicinal chemistry.

Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives.

Zhenyu Cai, Jiao Li, Xu‐Wen Li, 2022, Journal of medicinal chemistry.

Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides.

Guodong Liu, C. Xing, Lijuan Xu, 2022, Journal of medicinal chemistry.

Role of Necroptosis in Central Nervous System Diseases.

T. Han, Pei Wang, Hong-Li Shao, 2022, ACS chemical neuroscience.

An alternative route for synthesis of o-trifluoroacetylanilines as useful fluorine-containing intermediates

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2010 .

Synthesis and Pharmacological Evaluation of Novel Homocamptothecin-Dihydropyridine Derivative Conjugates as Potent Topoisomerase I Inhibitors

W. Guo, Wenfeng Liu, Zhenyuan Miao, 2011 .

DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output

Ying Shi, Yan-ran Wu, Jian-qiang Yu, 2021, RSC advances.

Dietary 5,6,7-Trihydroxy-flavonoid Aglycones and 1-Deoxynojirimycin Synergistically Inhibit the Recombinant Maltase-Glucoamylase Subunit of α-Glucosidase and Lower Postprandial Blood Glucose.

Z. Xiu, N. Yu, Yuesheng Dong, 2020, Journal of agricultural and food chemistry.

Asymmetric synthesis of (-)-solanidine and (-)-tomatidenol.

W. Tian, Guan-xin Huang, Chunlin Zhuang, 2020, Organic & biomolecular chemistry.

Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors.

Jian Li, Guoqiang Dong, Zhenyuan Miao, 2017, Journal of medicinal chemistry.

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N, E138K Mutants, and Pharmacokinetic Profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2020, ACS infectious diseases.

Design, Synthesis and Biological Evaluation of Sulfamide and Triazole Benzodiazepines as Novel p53-MDM2 Inhibitors

Guoqiang Dong, Zhenyuan Miao, Jianzhong Yao, 2014, International journal of molecular sciences.

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Acta pharmaceutica Sinica. B.

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Acta pharmaceutica Sinica. B.

Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors

Wei Guo, Wenfeng Liu, Yongqiang Zhang, 2012, Journal of enzyme inhibition and medicinal chemistry.

Natural Indole Alkaloids from Marine Fungi: Chemical Diversity and Biological Activities

Jiao Li, Chunlin Zhuang, 2021, Pharmaceutical Fronts.

Enantioselective Total Syntheses of (-)-20-epi-Vincamine and (-)-20-epi-Eburnamonine via Ir-Catalyzed Asymmetric Imine Hydrogenation/Lactamization Cascade.

Y. An, Fen‐er Chen, Wen Zhang, 2020, Chemistry.

Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains.

Shengzheng Wang, G. Jin, Yongqiang Zhang, 2012, European journal of medicinal chemistry.

Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships.

Xinhua Lu, Yuesheng Dong, Zhihui Zheng, 2017, Bioorganic & medicinal chemistry letters.

Trivaric acid, a new inhibitor of PTP1b with potent beneficial effect on diabetes

Xia Li, Z. Xiu, C. Quan, 2017, Life sciences.

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

Chunlin Zhuang, Zhuo Qu, Yan Ding, 2023, Nutrients.

Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.

G. Bifulco, R. Riccio, Hua Tang, 2017, Marine drugs.

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy

E. De Clercq, C. Pannecouque, Fener Chen, 2020, Molecules.

β‐Alanine‐DBU: A Highly Efficient Catalytic System for Knoevenagel‐Doebner Reaction under Mild Conditions

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2012 .

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

Y. Sham, Guoqiang Dong, Zhenyuan Miao, 2014, Oncotarget.

Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents

Wannian Zhang, Zhi-bin Wang, Chen-xi Zhang, 2020, Biomedicine & Pharmacotherapy.

Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.

Wannian Zhang, Lijuan Xu, Chunlin Zhuang, 2021, European journal of medicinal chemistry.

Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK.

E. De Clercq, C. Pannecouque, Li Ding, 2022, Journal of medicinal chemistry.

Peramivir, an Anti-Influenza Virus Drug, Exhibits Potential Anti-Cytokine Storm Effects

Xiao-chen Sun, Wannian Zhang, Zhi-bin Wang, 2020, bioRxiv.

Design strategies for long-acting anti-HIV pharmaceuticals.

Li Ding, Fen‐er Chen, Y. Sang, 2020, Current opinion in pharmacology.

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Bioorganic chemistry.

Small molecules inhibiting Keap1-Nrf2 protein-protein interactions: a novel approach to activate Nrf2 function.

Zhenyuan Miao, Chunlin Zhuang, Zhongli Wu, 2017, MedChemComm.

Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2014, Journal of medicinal chemistry.

Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease.

Wannian Zhang, Hao Shang, Ling He, 2020, Bioorganic chemistry.

Stereoselective Synthesis of (-)-Verazine and Congeners via a Cascade Ring-Switching Process of Furostan-26-acid.

Yunong Wang, W. Tian, P. Tang, 2020, Organic letters.

Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.

Chun-lin Zhuang, Fen‐er Chen, Chunlin Zhuang, 2020, Journal of medicinal chemistry.

Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.

E. De Clercq, C. Pannecouque, H. Piao, 2021, European journal of medicinal chemistry.

Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs.

E. De Clercq, C. Pannecouque, Li Ding, 2021, Journal of medicinal chemistry.

Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2021, Journal of medicinal chemistry.

Druggability modification strategies of the diarylpyrimidine‐type non‐nucleoside reverse transcriptase inhibitors

Chun-lin Zhuang, Li Ding, Fen‐er Chen, 2021, Medicinal research reviews.

Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020, European journal of medicinal chemistry.

Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1.

C. Pannecouque, E. Clercq, Fener Chen, 2020, Bioorganic chemistry.

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020, Molecules.

Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

E. De Clercq, C. Pannecouque, Fen‐er Chen, 2020, Bioorganic chemistry.

The Bcr-Abl inhibitor GNF-7 inhibits necroptosis and ameliorates acute kidney injury by targeting RIPK1 and RIPK3 kinases.

Hongyang Wang, Xiufeng Pang, Xiaofei Chen, 2020, Biochemical pharmacology.

Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.

J. Yu, Yue Liu, Hui Wang, 2020, Life sciences.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Synthesis and Biological Assays of 9‐(Acylamino)homocamptothecins as DNA Topoisomerase I Inhibitors

Wei Guo, Wenfeng Liu, Guoqiang Dong, 2013, Chemistry & biodiversity.

Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, European journal of medicinal chemistry.

Synthesis of 9‐(Heteroarylmethylidene)amino Derivatives of Homocamptothecin with Biological Activities

Wei Guo, Wenfeng Liu, Yongqiang Zhang, 2011, Chemistry & biodiversity.

Profiling of the chemical space on the phenyl group of substituted benzothiazole RIPK3 inhibitors.

Huanhai Liu, Wannian Zhang, Chunlin Zhuang, 2022, Bioorganic chemistry.

Synthesis and Biological Evaluation of 7‐Alkenyl Homocamptothecins as Potent Topoisomerase I Inhibitors

Wei Guo, Wenfeng Liu, Guoqiang Dong, 2012, Chemistry & biodiversity.

Topoisomerase I‐Mediated Antiproliferative Activity of 10‐Substituted and 12‐Substituted Homocamptothecins

W. Guo, Wenfeng Liu, Yongqiang Zhang, 2011 .

Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.

Shengzheng Wang, Wei Guo, Wenfeng Liu, 2011, European journal of medicinal chemistry.

Transcription Factor NRF2 as a Promising Therapeutic Target for Alzheimer's Disease.

Jiachen Sun, Wannian Zhang, Jianqiang Yu, 2020, Free radical biology & medicine.

Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice.

Z. Xiu, Yuesheng Dong, Y-Q Xing, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao, 2012, Journal of medicinal chemistry.

High-Throughput Screening in the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions

C. Sheng, Chun-lin Zhuang, Chunlin Zhuang, 2018 .

Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design.

C. Sheng, Long Chen, Yan Jiang, 2018, Journal of medicinal chemistry.

A Fluorescent Probe for Imaging p53–MDM2 Protein–Protein Interaction

Minyong Li, Zhenyuan Miao, C. Sheng, 2015, Chemical biology & drug design.

Small molecule-drug conjugates: A novel strategy for cancer-targeted treatment.

Zhenyuan Miao, Wannian Zhang, Chun-lin Zhuang, 2019, European journal of medicinal chemistry.

Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, Bioorganic & medicinal chemistry letters.

Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.

Jianqiang Yu, Wannian Zhang, Jianhong Yang, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Characterization of different forms of kava (Piper methysticum) products by UPLC-MS/MS

C. McCurdy, Abhisheak Sharma, K. S. Raju, 2021, Planta Medica.

Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53-MDM2 protein-protein interaction.

Guoqiang Dong, Shengzheng Wang, Yang Liu, 2011, European journal of medicinal chemistry.

An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules.

Y. Sham, D. Odde, John K. Lee, 2018, Molecular pharmaceutics.

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020 .

Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway.

Wannian Zhang, Lijuan Xu, L. Xue, 2023, Journal of medicinal chemistry.

Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions

Lijuan Xu, Chunlin Zhuang, 2023, Medicinal research reviews.

Radiosensitization of human pancreatic cancer by piperlongumine analogues

Zhenyuan Miao, Wannian Zhang, Huojun Zhang, 2020 .

N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[ d]thiazol-2-yl)cyclopropanecarboxamide (TAK-632) Analogues as Novel Necroptosis Inhibitors by Targeting Receptor-Interacting Protein Kinase 3 (RIPK3): Synthesis, Structure-Activity Relationships, and in Vivo Efficacy.

Xiaofei Chen, Zhenyuan Miao, Wannian Zhang, 2019, Journal of medicinal chemistry.

Chemical space exploration of novel naphthyl-carboxamide-diarylpyrimidine derivatives with potent anti-HIV-1 activity.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2021, Bioorganic chemistry.

Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present)

Wannian Zhang, Lijuan Xu, Chunlin Zhuang, 2023, Expert opinion on therapeutic patents.

Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.

Wannian Zhang, Zhi-bin Wang, Hao Ma, 2020, European journal of medicinal chemistry.

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease.

Lijuan Xu, Yi Sun, Hong-Li Shao, 2022, Journal of medicinal chemistry.

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, European journal of medicinal chemistry.

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.

Hui Wang, Ning Liu, Tao Sun, 2019, ACS chemical neuroscience.

Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

Weihong Zhou, Guoqiang Dong, Zhenyuan Miao, 2017 .

Analysis on benzothiazole necroptosis inhibitors with chiral substitutions in the solvent-accessible region of RIP kinase domain.

Shuyu Wang, Lijuan Xu, Hong-Li Shao, 2023, Bioorganic chemistry.

Methodology of drug screening and target identification for new necroptosis inhibitors

Y. Chai, Xiaofei Chen, Zhenyu Cai, 2018, Journal of pharmaceutical analysis.

Identification of a novel small-molecule Keap1–Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy

João Paulo Figueiró Longo, Hua Zhang, K. Zhu, 2018, Journal of enzyme inhibition and medicinal chemistry.

Fragment‐growing guided design of Keap1‐Nrf2 protein‐protein interaction inhibitors for targeting myocarditis

H. Zhang, N. Meng, Hua Tang, 2018, Free radical biology & medicine.

Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy.

Xiaoxia Liu, Xin Luan, Ye Wu, 2023, European journal of medicinal chemistry.

Structure-Based Design of Novel Alkynyl Thio-Benzoxazepinone Receptor-Interacting Protein Kinase-1 Inhibitors: Extending the Chemical Space from the Allosteric to ATP Binding Pockets.

Hongbin Yuan, Hong-Li Shao, Wannian Zhang, 2023, Journal of medicinal chemistry.

Structure-Based Design of Marine-derived Meridianin C Derivatives as Glycogen synthase kinase 3β inhibitors with improved oral bioavailability: From aminopyrimidyl-indoles to the sulfonyl analogues

Wei Zhou, Fen‐er Chen, Shuwen Han, 2021, Bioorganic Chemistry.

Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction.

Minyong Li, H. Fang, C. Sheng, 2017, MedChemComm.

Fragment-Based Discovery of Azocyclic Alkyl Naphthalenesulfonamides as Keap1-Nrf2 Inhibitors for Acute Lung Injury Treatment.

Zhenyuan Miao, Li Ding, Cheng-Shi Jiang, 2023, Journal of medicinal chemistry.

Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β

Wei Zhou, Fen‐er Chen, Shuwen Han, 2021, Marine drugs.

A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease

Guodong Liu, Lijuan Xu, Ling He, 2023, Redox biology.

Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review.

Zhenyuan Miao, Wannian Zhang, C. Sheng, 2014, Current medicinal chemistry.

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search.

Y. Sham, Wannian Zhang, Chunlin Zhuang, 2014, Journal of medicinal chemistry.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Enantiomeric profiling of a chiral benzothiazole necroptosis inhibitor.

Wannian Zhang, Lijuan Xu, Hao Zhang, 2021, Bioorganic & Medicinal Chemistry Letters.

Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, European journal of medicinal chemistry.

Antitumor Activities and Structure–Activity Relationship of Phosphotriester Derivatives of Homocamptothecin Based on a Semisynthetic Route

Juan Wang, Shengzheng Wang, Yongqiang Zhang, 2011 .

Swinhoeisterols from the South China Sea Sponge Theonella swinhoei.

A. Mándi, T. Kurtán, Hua Tang, 2018, Journal of Natural Products.

Diallyl Disulfide Blocks Cigarette Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Tumorigenesis via Activation of the Nrf2 Antioxidant System and Suppression of NF-κB Inflammatory Response.

Wannian Zhang, Chunlin Zhuang, Zhuo Qu, 2023, Journal of agricultural and food chemistry.

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

Y. Sham, Guoqiang Dong, Zhenyuan Miao, 2014, Oncotarget.

Unambiguous Identification of β‐Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling

P. Villalta, Bo Zhou, Y. Lin, 2016, ChemMedChem.