J. R. McConnell

发表

Chemically accessible hsp90 inhibitor that does not induce a heat shock response.

Yao Wang, S. McAlpine, Y. Koay, 2014, ACS medicinal chemistry letters.

Blocking the heat shock response and depleting HSF-1 levels through heat shock protein 90 (hsp90) inhibition: a significant advance on current hsp90 chemotherapies

Yao Wang, S. McAlpine, Y. Koay, 2015 .

A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response.

S. McAlpine, J. R. McConnell, L. A. Alexander, 2014, Bioorganic & medicinal chemistry letters.

Targeting the C-Terminus of Hsp90 as a Cancer Therapy

Yao Wang, S. McAlpine, J. R. McConnell, 2015 .

An Hsp90 modulator that exhibits a unique mechanistic profile.

D. Ramsey, S. McAlpine, L. Alexander, 2012, Bioorganic & medicinal chemistry letters.

Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains.

H. Dyson, S. McAlpine, J. R. McConnell, 2021, RSC medicinal chemistry.

Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90.

Joseph B. Kunicki, S. McAlpine, L. Alexander, 2011, Bioorganic & medicinal chemistry letters.

Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach.

S. McAlpine, L. K. Buckton, J. R. McConnell, 2015, Bioorganic & medicinal chemistry letters.

An efficient route to benzo[b]thiophenequinones, quinone bisketals, and quinone monoketals via anodic oxidation of methoxylated benzo[b]thiophenes. Studies directed at the synthesis of functionalized benzo[b]thiophene-4,7-quinones

B. Chenard, J. R. McConnell, J. S. Swenton, 1983 .

Evaluating Dual Hsp90 and Hsp70 Inhibition as a Cancer Therapy

Yao Wang, S. McAlpine, L. K. Buckton, 2015 .

Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets.

S. McAlpine, J. R. McConnell, 2013, Bioorganic & medicinal chemistry letters.

A potential rhodium cancer therapy: studies of a cytotoxic organorhodium(I) complex that binds DNA.

D. Ramsey, S. McAlpine, M. L. Cole, 2013, Bioorganic & medicinal chemistry letters.