K. Shimomura

发表

The effect of droloxifene on the insulin-like growth factor-I-stimulated growth of breast cancer cells.

I. Kawamura, S. Tsujimoto, F. Nishigaki, 1994, Anticancer research.

FK317: a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome

I. Kawamura, S. Tsujimoto, M. Inami, 1998, Cancer Chemotherapy and Pharmacology.

FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by Chromobacterium violaceum No. 968. Part 3. Antitumor Activities on Experimental Tumors in Mice.

I. Kawamura, F. Nishigaki, T. Manda, 1994 .

Different Effects of FK317 on Multidrug‐resistant Tumor in vivo and in vitro

I. Kawamura, S. Tsujimoto, M. Inami, 1998, Japanese journal of cancer research : Gann.

The role of caudate nucleus dopamine and cyclic AMP in the hyperpyrexia induced by LiCl plus tranylcypromine in rats.

M. Tomoi, J. Mori, K. Shimomura, 1979, Japanese journal of pharmacology.

Important role of serotonin in the antitumor effects of recombinant human tumor necrosis factor-alpha in mice.

F. Nishigaki, J. Mori, T. Manda, 1988, Cancer research.

Recombinant human tumor necrosis factor-α: evidence of an indirect mode of antitumor activity

T. Oku, F. Nishigaki, J. Mori, 1987 .

Antitumor effects of droloxifene, a new antiestrogen drug, against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.

I. Kawamura, M. Kohsaka, N. Kondo, 1991, Japanese journal of pharmacology.

The efficacy of combined treatment with recombinant human tumor necrosis factor-alpha and 5-fluorouracil is dependent on the development of capillaries in tumor.

T. Nakamura, F. Nishigaki, T. Manda, 1990, European journal of cancer.

Recombinant human tumor necrosis factor‐α: Thrombus formation is a cause of anti‐tumor activity

J. Mori, T. Manda, K. Shimomura, 1988, International journal of cancer.

Bovine placental lactogen: molecular cloning and protein structure.

L. Schuler, M. Kessler, R. Bremel, 1988, Biochemistry.

Characterization of bovine placental lactogen as a glycoprotein with N-linked and O-linked carbohydrate side chains.

R. Bremel, K. Shimomura, 1988, Molecular endocrinology.

Effects of a new non-steroidal 5 alpha-reductase inhibitor, FK143, on the prostate gland in beagle dogs.

I. Kawamura, S. Tsujimoto, M. Inami, 1997, Japanese journal of pharmacology.

Intratumoral injection of oligonucleotides to the NFκB binding site inhibits cachexia in a mouse tumor model

T. Ogihara, Y. Kaneda, R. Morishita, 1999, Gene Therapy.

Combined blockade of 5-HT3- and 5-HT4-serotonin receptors inhibits colonic functions in conscious rats and mice.

K. Tokita, M. Kadowaki, Y. Nagakura, 1997, The Journal of pharmacology and experimental therapeutics.

Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall.

F. Ito, M. Matsuo, M. Tomoi, 1995, Biochimica et biophysica acta.

Effects of a Novel Pyridylsulphonyl Thiazole Derivative, FR115092, on Autoimmune and Mitomycin C‐induced Thrombycytopenia in Mice

I. Kawamura, S. Tsujimoto, M. Inami, 1999, The Journal of pharmacy and pharmacology.

Recombinant human tumor necrosis factor-alpha: evidence of an indirect mode of antitumor activity.

T. Oku, F. Nishigaki, J. Mori, 1987, Cancer research.

Possible involvement of calpain in the growth of estrogen receptor positive breast cancer cells.

T. Taguchi, I. Kawamura, S. Tsujimoto, 1996, Anticancer research.

Cholesterol‐lowering effect of an acyl‐coenzyme A: Cholesterol acyltransferase inhibitor, FR145237, in hypercholesterolemic rabbits fed a high‐cholesterol diet and a cholesterol‐free casein diet

M. Matsuo, M. Tomoi, K. Shimomura, 1995 .

Anti‐cachectic Effect of FK317, a Novel Anti‐cancer Agent, in Colon26 and LX‐1 Models in Mice

I. Kawamura, S. Tsujimoto, M. Inami, 1998, Japanese journal of cancer research : Gann.

Effects of anti-inflammatory drugs on triple vaccine-induced pleurisy in rats.

H. Satoh, J. Mori, K. Shimomura, 1982, Japanese journal of pharmacology.

A simple histochemical screening method for amine uptake.

J. Mori, K. Shimomura, R. Saitoh, 1980, Japanese journal of pharmacology.

An approach to high-level production of a mecasermin (somatomedin C) fused protein in Escherichia coli HB101

Hisashi Yamada, Yoshimasa Saito, M. Yamaguchi, 1996 .

The estrogenic and antiestrogenic activities of droloxifene in human breast cancers.

I. Kawamura, M. Kohsaka, Y. Tanaka, 1993, Japanese Journal of Pharmacology.

FR 149175, a ƒÀ3-Adrenoceptor-Selective Agonist, Is a Possible Therapeutic Agent for Non-Insulin-Dependent Diabetes Mellitus

Tadashi, S. Takakura, M. Tomoi, 2006 .

TRANSCRIPTIONAL INHIBITION OF INSULIN BY FK506 AND POSSIBLE INVOLVEMENT OF FK506 BINDING PROTEIN‐12 IN PANCREATIC β-CELL

T. Fujimura, K. Ohara, Y. Hirano, 1995, Transplantation.

Recombinant insulin-like growth factor I normalizes expression of renal glucose transporters in diabetic rats.

M. Kobayashi, M. Iwai, K. Shimomura, 1997, The American journal of physiology.

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action.

M. Okuhara, H. Nakajima, H. Terano, 1996, The Journal of antibiotics.

A new antitumor antibiotic, FK973: its metabolism in the blood and the antitumor effects of its metabolites on experimental models.

T. Nakamura, S. Takagaki, H. Noguchi, 1989, Japanese journal of pharmacology.

Antitumor activity and hematotoxicity of a new, substituted dihydrobenzoxazine, FK973, in mice.

T. Nakamura, T. Oku, F. Nishigaki, 1988, Cancer research.

Effect of FR143430, a novel cytokine suppressive agent, on adenocarcinoma colon26-induced cachexia in mice.

N. Yamamoto, I. Kawamura, S. Tsujimoto, 1998, Anticancer research.

A new aromatase inhibitor, FR901537. II. Pharmacological and antitumor effects.

I. Kawamura, S. Tsujimoto, Y. Naoe, 1995, The Journal of antibiotics.

A new antitumor antibiotic, FR-900482: V. Interstrand DNA-DNA cross-links in L1210 cells.

T. Nakamura, M. Kohsaka, H. Terano, 1988, The Journal of antibiotics.

A new antitumor antibiotic, FR-900482. III. Antitumor activity in transplantable experimental tumors.

J. Mori, F. Shibayama, T. Mizota, 1987, The Journal of antibiotics.

Interstrand DNA-DNA and DNA-protein cross-links by a new antitumor antibiotic, FK973, in L1210 cells.

T. Nakamura, J. Mori, T. Mizota, 1988, Cancer research.

Specific metabolic activation of FK973, a new antitumor antibiotic, in L1210 leukemia cells.

T. Nakamura, K. Shimomura, K. Masuda, 1990, Japanese journal of pharmacology.

Effect of FK973, a new antitumor antibiotic, on the cell cycle of L1210 cells in vitro.

T. Nakamura, T. Oku, J. Mori, 1989, Japanese journal of pharmacology.

A NEW ANTITUMOR ANTIBIOTIC, FR-900482

J. Mori, T. Mizota, K. Shimomura, 1987 .

A new antitumor antibiotic, FR-900482. IV. Hematological toxicity in mice.

J. Mori, T. Mizota, K. Shimomura, 1987, The Journal of antibiotics.

Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain

M. Niwa, Y. Noguchi, Y. Saito, 1997, Applied and environmental microbiology.

Interaction of tacrolimus(FK506) and its metabolites with FKBP and calcineurin.

T. Kuno, C. Tanaka, T. Fujimura, 1994, Biochemical and biophysical research communications.

Isolation and characterization of multiple forms of bovine placental lactogen from secretory granules of the fetal cotyledon.

T. Duello, R. Bremel, J. Byatt, 1986, Endocrinology.

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.

I. Kawamura, I Kawamura, T Manda, 1994, The Journal of antibiotics.

A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors.

H. Nakada, K. Nakahara, M. Okuhara, 1989, Journal of antibiotics (Tokyo. 1968).

, Y strain . L-ascorbic acid , in a recombinant G . oxydans production of 2-keto-L-gulonate , a precursor of Gluconobacter oxydans and microbial L-sorbosone dehydrogenases from Cloning of genes coding for L-sorbose and

M. Niwa, Masaru Yoshida, Yoshimasa Saito, 1997 .

Large scale purification of recombinant insulin-like growth factor I (IGF-I, mecasermin) from a fused protein produced in Escherichia coli

Yoshimasa Saito, Tamotsu Fujimoto, Toru Mori, 1996 .

Binding Sites of Droloxifene in the Cytosol of 7,12‐Dimethylbenz[α]anthracene‐induced Rat Mammary Tumor Cells

I. Kawamura, F. Nishigaki, T. Manda, 1994, Japanese journal of cancer research : Gann.

Recombinant human tumor necrosis factor-alpha: thrombus formation is a cause of anti-tumor activity.

J. Mori, T. Manda, K. Shimomura, 1988, International journal of cancer.

Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats.

J. Mori, K. Shimomura, M. Hashimoto, 1979, Japanese journal of pharmacology.

Specific protein interacting with a tumor promoter, debromoaplysiatoxin, in bovine serum is α1-acid glycoprotein

M. Suganuma, H. Ueyama, K. Shimomura, 2005, Journal of Cancer Research and Clinical Oncology.

The central anti-serotonin activity of zotepine, a new neuroleptic, in rats.

S. Katsuki, M. Tomoi, H. Satoh, 1982, Japanese journal of pharmacology.

FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice

I. Kawamura, S. Tsujimoto, M. Inami, 1998, Japanese journal of cancer research : Gann.

Dopamine receptor blocking activity of sulpiride in the central nervous system.

Y. Satoh, R. Kato, S. Uchida, 1977, Japanese journal of pharmacology.

FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus.

T. Yamamoto, S. Takakura, M. Tomoi, 1997, Japanese journal of pharmacology.

Luminal dilution caused by certain mild irritants and capsaicin contributes to their gastric mucosal protection.

M. Matsuo, M. Tomoi, Y. Hatakeyama, 1995, American Journal of Physiology.

Implication of sensory neurons in the diverse mechanisms of adaptive cytoprotection in the rat stomach.

M. Tomoi, Y. Hatakeyama, M. Ohtsuka, 1996, Japanese journal of pharmacology.

High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176.

M. Niwa, T. Fujimura, M Niwa, 1995, European journal of biochemistry.

Antiestrogenic and antitumor effects of droloxifene in experimental breast carcinoma.

T. Nakamura, I. Kawamura, F. Nishigaki, 1989, Arzneimittel-Forschung.

Growth hormone (GH) secretion from human lymphocytes is up-regulated by GH, but not affected by insulin-like growth factor-I.

K. Ikekubo, K. Moridera, N. Hattori, 1993, The Journal of clinical endocrinology and metabolism.

Difference between normal and WHHL rabbits in susceptibility to the adrenal toxicity of an acyl-CoA:cholesterol acyltransferase inhibitor, FR145237.

J. Suzuki, M. Matsuo, M. Tomoi, 1996, Toxicology and applied pharmacology.

Effect of zotepine on fenfluramine-induced hyperthermia in rats.

H. Satoh, J. Mori, K. Shimomura, 1984, Japanese Journal of Pharmacology.

Effect of zotepine on head-twitch induced by L-5-hydroxytryptophan, mescaline and 2,5-dimethoxy-4-methylamphetamine in mice and rats.

T. Yamamoto, S. Ueki, H. Satoh, 1983, Japanese Journal of Pharmacology.

Backward walking induced by L-5-hydroxytryptophan in mice.

J. Mori, K. Shimomura, F. Honda, 1981, Japanese journal of pharmacology.

Oxidative modification of a cephalosporin C acylase from Pseudomonas strain N176 and site-directed mutagenesis of the gene

M. Niwa, T. Fujimura, Y. Noguchi, 1996, Applied and environmental microbiology.

Decreased progesterone binding and attenuated progesterone action in cultured human breast carcinoma cells treated with epidermal growth factor.

W. Blattner, J. Nadeau, C. Pui, 1988, Cancer research.

Potentiation of the toxicity of tumor necrosis factor by tumors in mice.

S. Tsujimoto, F. Nishigaki, K. Miyayasu, 1994, Circulatory shock.