Syng-Ook Lee

Syng-Ook Lee, Mi-Hee Yu, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sorbus commixta water extract induces apoptotic cell death via a ROS-dependent pathway

Hee-Jung Choi, Tae-Wook Chung, Ki-Tae Ha, 2018, Oncology letters.

Extracts from Paeonia lactiflora Pallas , Rehmannia Glutinosa

Hee-Jung Choi, Myeong Soo Lee, Tae-Wook Chung, 2019 .

Peroxisome proliferator-activated receptor γ-dependent activity of indole ring-substituted 1,1-bis(3′-indolyl)-1-(p-biphenyl)methanes in cancer cells

Sung-Dae Cho, P. Lei, Sudhakar Chintharlapalli, 2010, Cancer Chemotherapy and Pharmacology.

Water-extracted tubers of Cyperus rotundus L. enhance endometrial receptivity through leukemia inhibitory factor-mediated expression of integrin αVβ3 and αVβ5.

Hee-Jung Choi, Tae-Wook Chung, Ki-Tae Ha, 2017, Journal of ethnopharmacology.

Induction of apoptosis by immature fruits of Prunus salicina Lindl. cv. Soldam in MDA-MB-231 human breast cancer cells

C. Sung, In‐Seon Lee, Syng-Ook Lee, 2007, International Journal of Food Science and Nutrition.

Myristica fragrans Suppresses Tumor Growth and Metabolism by Inhibiting Lactate Dehydrogenase A.

Hee-Jung Choi, Tae-Wook Chung, Jung-Hye Choi, 2016, The American journal of Chinese medicine.

Enzymatic Preparation and Antioxidant Activities of Protein Hydrolysates from Allomyrina dichotoma Larvae

Hee-Jeong Ryu, Hyun-Ji Song, Syng-Ook Lee, 2019, Journal of the Korean Society of Food Science and Nutrition.

Analysis of the Component and Immunological Efficacy of Chamaecyparis obtusa Leaf Extract

Keuk-Jun Kim, Sun Gun Kim, Syng-Ook Lee, 2018 .

The nuclear orphan receptor NR4A1 regulates β1‐integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists

S. Safe, E. Hedrick, Syng-Ook Lee, 2017, Molecular carcinogenesis.

Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins.

Hee-Jung Choi, Tae-Wook Chung, Ki-Tae Ha, 2016, Journal of pharmacological sciences.

Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors.

S. Safe, Sung-Dae Cho, K. Yoon, 2011, Carcinogenesis.

The Oral Administration of Sanguisorba officinalis Extract Improves Physical Performance through LDHA Modulation

D. Ryu, Ki-Tae Ha, J. Han, 2021, Molecules.

Anti-oxidant and Anti-inflammatory Activities of Barley Sprout Extract

E. Hwang, Seun-ah Yang, Syng-Ook Lee, 2016 .

Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy.

S. Safe, Mandip Singh, R. Doddapaneni, 2015, Endocrine-related cancer.

Nuclear receptor 4 A 1 as a drug target for breast cancer chemotherapy

Mandip Singh, R. Doddapaneni, E. Hedrick, 2015 .

Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells

S. Safe, H. Lee, Syng-Ook Lee, 2017, Toxicology and applied pharmacology.

Novel hepatoprotective peptides derived from protein hydrolysates of mealworm (Tenebrio molitor).

Syng-Ook Lee, Hye-Rin Cho, 2020, Food research international.

Defatted safflower seed extract inhibits adipogenesis in 3T3-L1 preadipocytes and improves lipid profiles in C57BL/6J ob/ob mice fed a high-fat diet.

E. Hwang, S. Lee, Syng-Ook Lee, 2016, Nutrition research.

Antiobesity and Hepatoprotective Effects of Protein Hydrolysates Derived from Protaetia brevitarsis in an Obese Mouse Model

S. Chun, In‐Seon Lee, J. N. Lee, 2022, BioMed research international.

The Antidiabetic Effect of Dietary Persimmon (Diospyros kaki L. cv. Sangjudungsi) Peel in Streptozotocin-induced Diabetic Rats

Shin-Kyo Chung, Syng-Ook Lee, I.-S. Lee, 2006 .

Nutritive Qualities of Food The Antidiabetic Effect of Dietary Persimmon ( Diospyros kaki L . cv . Sangjudungsi ) Peel in Streptozotocin-induced Diabetic Rats

Syng-Ook Lee, 2022 .

Chromatin , Gene , and RNA Regulation The Orphan Nuclear Receptor NR 4 A 1 ( Nur 77 ) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

Ju-Seog Lee, S. Safe, Sandeep Sreevalsan, 2014 .

Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth

S. Safe, R. Shrestha, K. Mohankumar, 2021, Journal of Experimental & Clinical Cancer Research.

Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.

Huamin Wang, M. Abdelrahim, K. Yoon, 2010, Cancer research.

Development of natural fermented seasoning with Flammulina velutipes powder fortified with γ-aminobutyric acid (GABA) by lactic acid fermentation

E. Park, S. Lee, Syng-Ook Lee, 2017 .

Wogonin suppresses TNF-α-induced MMP-9 expression by blocking the NF-κB activation via MAPK signaling pathways in human aortic smooth muscle cells

Cheorl-Ho Kim, Yun-Jeong Jeong, In‐Seon Lee, 2006 .

Anemone rivularis inhibits pyruvate dehydrogenase kinase activity and tumor growth.

Hee-Jung Choi, Tae-Wook Chung, Ki-Tae Ha, 2017, Journal of ethnopharmacology.

The pharmacological potential of Sorbus commixta cortex on blood alcohol concentration and hepatic lipid peroxidation in acute alcohol‐treated rats

In‐Seon Lee, Syng-Ook Lee, Hang Lee, 2006, The Journal of pharmacy and pharmacology.

Effect of Saliva miltiorrhiza bunge on antimicrobial activity and resistant gene regulation against methicillin-resistant Staphylococcus aureus (MRSA).

In‐Seon Lee, Ji-Won Lee, Syng-Ook Lee, 2007, Journal of microbiology.

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target.

S. Safe, U. Jin, Syng-Ook Lee, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Anti-Browning Effect of Plum Seed Extracts from Different Cultivars

Ji-won Park, Syng-Ook Lee, Tae-Jeong Lee, 2021 .

Enzymatic Preparation and Antioxidant Activities of Protein Hydrolysates from Protaetia brevitarsis Larvae

Hee-Jeong Ryu, H. Lee, Syng-Ook Lee, 2016 .

Induction of Quinone Reductase, The Phase 2 Anticarcinogenic Marker Enzyme, in Hepa1c1c7 Cells by Radish Sprouts, Raphanus sativus L.

In‐Seon Lee, Syng-Ook Lee, 2006 .

Water-extracted branch of Cinnamomum cassia promotes lung cancer cell apoptosis by inhibiting pyruvate dehydrogenase kinase activity.

Tae-Wook Chung, Ki-Tae Ha, Eun-Yeong Kim, 2018, Journal of pharmacological sciences.

Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.

Stephen Safe, S. Safe, U. Jin, 2014, Molecular endocrinology.

Polyphenol Contents and Antioxidant Activities of Lentil Extracts from Different Cultivars

So-Hee Lee, Syng-Ook Lee, 2016 .

Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.

M. Abdelrahim, R. Burghardt, C. Baker, 2009, Carcinogenesis.

Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities

Kyongbum Lee, A. Jayaraman, S. Safe, 2014, Molecular Pharmacology.

Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway

Sung-Dae Cho, J. Kim, Ji-Youn Jung, 2010, Journal of clinical biochemistry and nutrition.

In Vitro and In Vivo Protective Effects of Lentil (Lens culinaris) Extract against Oxidative Stress-Induced Hepatotoxicity

S. Chun, Dae Hwan Kim, Man-Hoon Han, 2021, Molecules.

Renal Protective Effect of Beluga Lentil Pretreatment for Ischemia-Reperfusion Injury

S. Chun, J. N. Lee, Y. Ha, 2021, BioMed research international.

The p38 MAPK pathway is critical for 5,5′-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells

M. Abdelrahim, G. Kong, Sung-Dae Cho, 2010, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells.

S. Safe, R. Burghardt, Xinyi Liu, 2010, Journal of molecular endocrinology.

MDM 2 regulates estrogen rece ptor a and estrogen responsiveness in breast cancer cells

S. Safe, R. Burghardt, Xinyi Liu, 2011 .

Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo

S. Safe, Keuk-Jun Kim, H. Lee, 2018, International Journal of Obesity.

Paeonia lactiflora Enhances the Adhesion of Trophoblast to the Endometrium via Induction of Leukemia Inhibitory Factor Expression

Hee-Jung Choi, Tae-Wook Chung, Ki-Tae Ha, 2016, PloS one.

microRNA 181a-5p Reprogramed Glucose and Lipid Metabolism in Non- Small Cell Lung Cancer

S-L Yu, J. Kang, Syng-Ook Lee, 2018 .

IDENTIFICATION OF ONCOGENIC MicroRNA-17-92/ZBTB4/SPECIFICITY PROTEIN AXIS IN BREAST CANCER

Stephen Safe, P. Defossez, Ju-Seog Lee, 2011, Oncogene.

Inhibition of pituitary tumor‐transforming gene‐1 in thyroid cancer cells by drugs that decrease specificity proteins

L. Santarpia, S. Sherman, P. Lei, 2011, Molecular carcinogenesis.

Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors

S. Safe, V. Nair, Satya S. Pathi, 2012, PloS one.

Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

S. Safe, I. Jutooru, P. Lei, 2012, Molecular Cancer Therapeutics.

Aryl Hydrocarbon Receptor (AHR)-Active Pharmaceuticals Are Selective AHR Modulators in MDA-MB-468 and BT474 Breast Cancer Cells

S. Safe, U. Jin, Syng-ook Lee, 2012, Journal of Pharmacology and Experimental Therapeutics.

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S. Safe, U. Jin, Syng-Ook Lee, 2012 .

Aryl Hydrocarbon Receptor ( AHR )-Active Pharmaceuticals Are Selective AHR Modulators in MDA-MB-468 and BT 474 Breast Cancer Cells

Syng-ook Lee, Syng-Ook Lee, 2012 .

Caesalpinia sappan induces apoptotic cell death in ectopic endometrial 12Z cells through suppressing pyruvate dehydrogenase kinase 1 expression

Hee-Jung Choi, Tae-Wook Chung, Jung-Hye Choi, 2021, Experimental and therapeutic medicine.

NR4A Orphan Receptors as Drug Targets

S. Safe, Beiyan Zhou, Syng-ook Lee, 2015 .

NR4A orphan receptors and cancer

S. Safe, Kyounghyun Kim, Xi Li, 2011 .

Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma

S. Safe, M. Abdelrahim, U. Jin, 2015, PloS one.

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration

Stephen Safe, S. Safe, Mandip Singh, 2016, Molecular and Cellular Biology.

Activation of Nerve Growth Factor-Induced Bα by Methylene-Substituted Diindolylmethanes in Bladder Cancer Cells Induces Apoptosis and Inhibits Tumor Growth

M. Abdelrahim, A. Kamat, K. Yoon, 2010, Molecular Pharmacology.

The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis

S. Safe, U. Jin, C. Pfent, 2014, BMC Cancer.

Suppression of PMA-induced tumor cell invasion by capillarisin via the inhibition of NF-kappaB-dependent MMP-9 expression.

Cheorl-Ho Kim, Yun-Jeong Jeong, In‐Seon Lee, 2008, Biochemical and biophysical research communications.

Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells.

In-Seon Lee, Young-Chae Chang, Cheorl-Ho Kim, 2007, Biochemical and biophysical research communications.

Targeting NR4A1 (TR3) in cancer cells and tumors

S. Safe, Shaheen Khan, Xi Li, 2011, Expert opinion on therapeutic targets.

Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells

Sung-Dae Cho, J. Shim, K. Kwon, 2011, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells

Sung-Dae Cho, N. Cho, Ji-Ae Shin, 2013, Experimental and therapeutic medicine.

Apomorphine suppresses TNF-α-induced MMP-9 expression and cell invasion through inhibition of ERK/AP-1 signaling pathway in MCF-7 cells.

Syng-Ook Lee, Yeon-Seop Jung, 2017, Biochemical and biophysical research communications.

Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo

S. Safe, Dae Hwan Kim, Keuk-Jun Kim, 2022, International journal of molecular sciences.

Preparation and Quality Characteristics of Yogurt Added with Saururus chinensis (Lour.) Bail

Hyun-Soo Kim, Syng-Ook Lee, In-Seon Lee, 2002 .

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.

S. Safe, Qiao Wu, D. Backos, 2014, Molecular endocrinology.

Effects of Aucklandia lappa Decne. Extract on Hair Growth in Depilated CL57BL/6 Mice

Keuk-Jun Kim, Syng-Ook Lee, Joung-Hee Kim, 2021, The Korean Journal of Clinical Laboratory Science.

Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells.

Cheorl-Ho Kim, Yun-Jeong Jeong, In‐Seon Lee, 2006, Biochemical and biophysical research communications.

Elecampane (Inula helenium) Root Extract and Its Major Sesquiterpene Lactone, Alantolactone, Inhibit Adipogenesis of 3T3-L1 Preadipocytes

Yun-Jeong Jeong, Syng-Ook Lee, Chang-Hwan Jeon, 2022, Molecules.

The Nuclear Receptor TR3 Regulates mTORC1 Signaling in Lung Cancer Cells Expressing Wild-type p53

S. Safe, Kyounghyun Kim, U. Jin, 2011, Oncogene.

Effects of Tissue Cultured Ginseng on Blood Glucose and Lipids in Streptozotocin-Induced Diabetic Rats

Syng-Ook Lee, In-Seon Lee, In-Za Lee, 2003 .

Panax notoginseng Inhibits Tumor Growth through Activating Macrophage to M1 Polarization.

Tae-Wook Chung, Ki-Tae Ha, Bosung Kim, 2018, The American journal of Chinese medicine.

Extracellular signal‑regulated kinase inhibition is required for methanol extract of Smilax china L.‑induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells.

Sung-Dae Cho, K. Kwon, Ji-Ae Shin, 2014, Molecular medicine reports.

Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells

S. Safe, H. Lee, S. Kim, 2021, Molecules.

Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)

Kyongbum Lee, A. Jayaraman, S. Safe, 2023, International journal of molecular sciences.

Protaetia Brevitarsis-Derived Protein Hydrolysate Reduces Obesity-Related Colitis Induced by High-Fat Diet in Mice through Anti-Inflammatory Pathways

S. Chun, J. N. Lee, Y. Ha, 2023, International journal of molecular sciences.