G. Hartman

发表

Farnesyltransferase inhibitor (L-744,832) restores TGF-β type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2

Mansoor M Ahmed, R. Alcock, D. Chendil, 2002, Oncogene.

A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth in Vivo

B. Connolly, D. Heimbrook, J. Shipman, 2004, Cancer Research.

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

Q. She, N. Rosen, K. Leander, 2010, Cancer biology & therapy.

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus

S. Kuduk, C. Espiritu, A. Lam, 2018, Antimicrobial Agents and Chemotherapy.

Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.

W. Talloen, M. Yuen, D. J. Kim, 2019, Gastroenterology.

Identification of a new class of HBV capsid assembly modulator.

S. Kuduk, C. Espiritu, A. Lam, 2021, Bioorganic & medicinal chemistry letters.

SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.

S. Kuduk, C. Espiritu, A. Lam, 2019, Bioorganic & medicinal chemistry letters.

Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants

C. Espiritu, A. Lam, Lingjie Zheng, 2017, Antimicrobial Agents and Chemotherapy.

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.

T. Volz, M. Dandri, A. Lam, 2017, Gastroenterology.

O115 : High antiviral activity of the HBV core inhibitor NVR 3-778 in the humanized uPA/SCID mouse model

T. Volz, M. Dandri, A. Lam, 2015 .

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

C. Lukacs, C. Espiritu, A. Lam, 2015, Proceedings of the National Academy of Sciences.

P0640 : Effect of the combination of the HBV core inhibitor NVR 3-778 with nucleoside analogs or other HBV core inhibitors on the inhibition of HBV DNA replication in HepG2.2.15 cells

C. Espiritu, A. Lam, K. Klumpp, 2015 .

Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)

Bohumil Bednar, Jun Zhang, Paul Coleman, 2010, Molecular Imaging and Biology.

NVR 3-778, a First-in-Class HBV Core Inhibitor, Alone and in Combination with Peg-Interferon (PegIFN), in Treatment-Naive HBeAg-Positive Patients: Early Reductions in HBV DNA and HBeAg

M. Yuen, E. Gane, J. Lalezari, 2016 .