Lihong Cheng

发表

Pharmacodynamics‐based approach for efficacious human dose projection of BMS‐986260, a small molecule transforming growth factor beta receptor 1 inhibitor

Y. Shu, R. Borzilleri, M. Cvijic, 2020, Biopharmaceutics & drug disposition.

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

K. McIntyre, C. Chaudhry, L. Salter-Cid, 2019, Science Translational Medicine.

Heat Shock Cognate 70 kDa Protein Is the Target of Tetradecyl 2,3-Dihydroxybenzoate for Neuritogenic Effect in PC12 Cells

Lan Xiang, J. Qi, Lihong Cheng, 2021, Biomedicines.

The Insulin Receptor: A Potential Target of Amarogentin Isolated from Gentiana rigescens Franch That Induces Neurogenesis in PC12 Cells

Minoru Yoshida, H. Osada, Lan Xiang, 2021, Biomedicines.

Amarogentin from Gentiana rigescens Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress

Ying Wang, Lan Xiang, J. Qi, 2020, Oxidative medicine and cellular longevity.

NEMO binding domain of IKK‐2 encompasses amino acids 735–745

C. Mapelli, D. Riexinger, R. Ryseck, 2006, Journal of molecular recognition : JMR.

Anti-Aging Substances from Maca Supercritical Extract

Lan Xiang, J. Qi, Yanfei Lin, 2017 .

Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress

A. Matsuura, Lan Xiang, J. Qi, 2020, Oxidative medicine and cellular longevity.

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors

Subhashish Banerjee, Qihong Zhao, M. Tagen, 2021, Dermatology and Therapy.

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE

S. Spergel, K. McIntyre, J. Tokarski, 2019 .

349 - BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2, Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease

J. Chen, C. Chaudhry, K. Gillooly, 2018 .

Selective Inhibition of Tyrosine Kinase 2 With Deucravacitinib (BMS-986165) Compared With Janus Kinase 1−3 Inhibitors

Subhashish Banerjee, J. Throup, J. Burke, 2020 .

3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from Desmodium sambuense-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF-TrkB Signaling Pathways.

H. Osada, M. Muroi, Lan Xiang, 2019, Molecular pharmaceutics.

Periodic, Partial Inhibition of IκB Kinase β-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis

K. McIntyre, Laishun Chen, W. Pitts, 2009, Journal of Pharmacology and Experimental Therapeutics.

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.

Michael A. Galella, K. McIntyre, J. Barrish, 2020, ACS medicinal chemistry letters.

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

S. Spergel, K. McIntyre, D. Shuster, 2019, Journal of medicinal chemistry.

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.

James Lin, K. McIntyre, J. Tokarski, 2019, ACS medicinal chemistry letters.

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain*

Stephen R. Johnson, M. Witmer, J. Tokarski, 2015, The Journal of Biological Chemistry.

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked

Michael A. Galella, K. McIntyre, J. Barrish, 2016, Journal of medicinal chemistry.

Semi‐synthesis and Structure–Activity Relationship of Neuritogenic Oleanene Derivatives

T. Nishikawa, Atsuo Nakazaki, J. Qi, 2018, ChemMedChem.

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Michael A. Galella, K. McIntyre, J. Macor, 2019, Journal of medicinal chemistry.

Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care

K. McIntyre, A. Fura, K. Gillooly, 2017, PloS one.

Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract

Minoru Yoshida, Lan Xiang, Qiaobei Wu, 2019, Oxidative medicine and cellular longevity.

Inhibitors of Sporangia Formation of Phytophthora capsici from Polygonum capitatum

Yuanchao Wang, H. Kawagishi, U. Farooq, 2018, Tropical Journal of Natural Product Research.

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.

James Lin, K. McIntyre, D. Shuster, 2020, Journal of medicinal chemistry.

Lindersin B from Lindernia crustacea induces neuritogenesis by activation of tyrosine kinase A/phosphatidylinositol 3 kinase/extracellular signal-regulated kinase signaling pathway.

H. Osada, Lan Xiang, J. Qi, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Ehretiquinone from Onosma bracteatum Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction

A. Matsuura, U. Farooq, Lan Xiang, 2021, Oxidative medicine and cellular longevity.

Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium.

H. Osada, Zhonghua Ma, T. Nishikawa, 2018, Angewandte Chemie.

Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium

Zhonghua Ma, T. Nishikawa, Lan Xiang, 2018, Angewandte Chemie.

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

S. Spergel, K. McIntyre, J. Tokarski, 2019, Journal of medicinal chemistry.