Jin Liu

发表

Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.

Ruiyao Mai, Bulian Deng, Huiting Zhao, 2022, Journal of medicinal chemistry.

Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses.

Jianjun Chen, Jin Liu, Pingzheng Zhou, 2022, Biochemical pharmacology.

Discovery of novel 3-hydroxyandrosta-5,7-Diene-17-Carboxylic acid derivatives as anti-inflammatory bowel diseases (IBD) agents.

Jingxuan Chen, Wei Li, A. Slominski, 2021, European journal of medicinal chemistry.

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.

Shuwen Liu, M. Luo, Ling-Wei Li, 2020, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of benz‐fused five‐membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities

Jianjun Chen, Yao Liu, Jin Liu, 2021, Chemical biology & drug design.

Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity.

Jingxuan Chen, Zichao Yang, Huiting Zhao, 2021, Bioorganic chemistry.

Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia.

Jianjun Chen, Jian Luo, Ting Wu, 2021, European journal of medicinal chemistry.

Discovery of Novel Quinazoline-based KRAS G12C Inhibitors as Potential Anticancer Agents

Jingxuan Chen, Ruiyao Mai, Huiting Zhao, 2022, Bioorganic & Medicinal Chemistry.

Discovery of novel quinazoline-based covalent inhibitors of KRAS G12C with various cysteine-targeting warheads as potential anticancer agents.

Jingxuan Chen, Huiting Zhao, Ling-Wei Li, 2021, Bioorganic chemistry.

Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents.

Zichao Yang, Jianjun Chen, Hui Liao, 2022, European journal of medicinal chemistry.

Discovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening.

Zichao Yang, Ruiyao Mai, Bulian Deng, 2022, European journal of medicinal chemistry.

Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents.

Jingxuan Chen, Ling-Wei Li, Jianjun Chen, 2021, Journal of medicinal chemistry.

Synthesis of N ‐Carbonyl Acridanes as Highly Potent Inhibitors of Tubulin Polymerization via One‐Pot Copper‐Catalyzed Dual Arylation of Nitriles with Cyclic Diphenyl Iodoniums

Ling-Wei Li, Jianjun Chen, Jin Liu, 2020, Advanced Synthesis & Catalysis.

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects.

Jianjun Chen, Jin Liu, Yichang Ren, 2022, Journal of medicinal chemistry.

X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.

Zichao Yang, Jianjun Chen, Yuxi Wang, 2023, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities.

Ling-Wei Li, Yuyu Fang, Jianjun Chen, 2021, Bioorganic & medicinal chemistry.

Design, synthesis, and bioevaluation of imidazo [1,2-a] pyrazine derivatives as tubulin polymerization inhibitors with potent anticancer activities.

Yuxi Wang, Zichao Yang, Ruiyao Mai, 2022, Bioorganic & medicinal chemistry.

Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents.

Ling-Wei Li, Jianjun Chen, Ting Liu, 2023, Journal of medicinal chemistry.

HDAC-targeting epigenetic modulators for cancer immunotherapy.

Jianjun Chen, Jin Liu, Binbin Cheng, 2024, European journal of medicinal chemistry.

Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.

Jingxuan Chen, Ling-Wei Li, Jianjun Chen, 2022, Journal of medicinal chemistry.

Recent progress in the development of hypoxia-inducible factor 2α (HIF-2α) modulators: Inhibitors, agonists, and degraders (2009–2024)

Jianjun Chen, Jin Liu, Binbin Cheng, 2024, European Journal of Medicinal Chemistry.

Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy.

Jianjun Chen, Jian-Feng Xiao, Jin Liu, 2024, Journal of medicinal chemistry.