Rong Huang

发表

Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D

R. Marmorstein, Youchao Deng, Zhi Huang, 2021, bioRxiv.

Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs

J. Min, N. Noinaj, Karthik Srinivasan, 2020, bioRxiv.

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies.

J. Min, N. Noinaj, Christine E. Schaner Tooley, 2020, Journal of medicinal chemistry.

Novel Propargyl-linked Bisubstrate Analogs as Tight-binding Inhibitors for Nicotinamide N-Methyltransferase.

N. Noinaj, Linjie Li, Rong Huang, 2019, Journal of medicinal chemistry.

Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human αB-crystallin.

S. Filipek, Benlian Wang, R. Nagaraj, 2013, Biochemistry.

Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase

Rong Huang, Iredia D. Iyamu, 2020, bioRxiv.

A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes

Rong Huang, Iredia D. Iyamu, A. Al-Hamashi, 2021, Biomolecules.

Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Youchao Deng, Rong Huang, Dongxing Chen, 2020, bioRxiv.

Past, present, and perspectives of protein N-terminal methylation.

Rong Huang, Krystal Diaz, Ying Meng, 2021, Current opinion in chemical biology.

Mechanisms and inhibitors of nicotinamide N-methyltransferase.

Rong Huang, Iredia D. Iyamu, 2021, RSC medicinal chemistry.

Development of A Continuous Fluorescence-Based Assay for N-Terminal Acetyltransferase D

Y. Ho, Rong Huang, Lan Chen, 2020, bioRxiv.

Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents

Xian-li Ma, A-Fang Li, Qian Li, 2020, RSC advances.

Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition.

N. Noinaj, Youchao Deng, Rong Huang, 2023, Journal of medicinal chemistry.

Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

Ronen Marmorstein, Blair C. R. Dancy, R. Cole, 2010, Journal of the American Chemical Society.

Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold.

R. Borch, Rong Huang, Christine A Marian, 2011, Tetrahedron.

Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors.

A. Zakharov, Adam Yasgar, A. Jadhav, 2020, ACS Combinatorial Science.

Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.

A. Zakharov, Adam Yasgar, A. Simeonov, 2022, Journal of medicinal chemistry.

Effects of Oncohistone Mutations and PTM Crosstalk on the N-terminal Acetylation Activities of NatD

Y. Ho, Rong Huang, 2021, bioRxiv.

A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16

William Arbuthnot Sir Lane, J. Lucchesi, Edwin R. Smith, 2005, Molecular and Cellular Biology.

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

Sean D. Taverna, A. Feinberg, J. Qian, 2014, ACS chemical biology.

Acetylation at Lysine 16 Responsible for the Majority of Histone H 4 MSL Complex Is Drosophila the A Human Protein Complex Homologous to

William Arbuthnot Sir Lane, J. Lucchesi, Edwin R. Smith, 2005 .

Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.

Rong Huang, Krystal Diaz, A. Al-Hamashi, 2020, Current protein & peptide science.

Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK.

W. Tao, R. Geahlen, V. A. Martin, 2013, Biochemical pharmacology.

Enhanced interrogation: emerging strategies for cell signaling inhibition

P. Cole, Rong Huang, Isabel Martinez-Ferrando, 2010, Nature Structural &Molecular Biology.

Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase

R. Blumenthal, Xiaodong Cheng, A. Mai, 2023, ACS chemical biology.

An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2

J. Min, W. Tempel, Li Li, 2018, Communications Biology.

Facile synthesis of SAM-peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1.

Gang Zhang, Rong Huang, 2016, RSC advances.

Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds.

Xudong Qu, Zixin Deng, Yan Yan, 2015, Journal of the American Chemical Society.

Methyltransferases : Key Regulators in Cardiovascular Development and Disease

Y. Mao, Brianna D. Mackie, Rong Huang, 2016 .

Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.

R. Marmorstein, Youchao Deng, Zhi Huang, 2021, Journal of medicinal chemistry.

Structural basis for substrate recognition by the human N-terminal methyltransferase 1

J. Min, P. Loppnau, W. Tempel, 2015, Genes & development.

Chemical Biology of Protein N‐Terminal Methyltransferases

Rong Huang, 2019, Chembiochem : a European journal of chemical biology.

Unlocking the mysteries of alpha-N-terminal methylation and its diverse regulatory functions

T. Hazbun, Rong Huang, Panyue Chen, 2023, The Journal of biological chemistry.

Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1

Jonah Z. Vilseck, Rong Huang, Iredia D. Iyamu, 2022, Molecules.

Chemoproteomic Study Uncovers HemK2/KMT9 As a New Target for NTMT1 Bisubstrate Inhibitors.

Xiaodong Cheng, N. Noinaj, Dan Yu, 2021, ACS chemical biology.

Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.

N. Noinaj, Youchao Deng, Rong Huang, 2021, ACS medicinal chemistry letters.

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies

J. Min, N. Noinaj, C. Tooley, 2020, bioRxiv.

Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.

N. Noinaj, Rong Huang, Dongxing Chen, 2019, Journal of medicinal chemistry.

Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors.

Gang Zhang, Y. Mao, S. Richardson, 2015, Organic & biomolecular chemistry.

Kinetic Mechanism of Protein N-terminal Methyltransferase 1*

Gang Zhang, Y. Mao, S. Richardson, 2015, The Journal of Biological Chemistry.

Chemoproteomic study uncovers HemK2/KMT9 as a new target for NTMT1 bisubstrate inhibitors

Xiaodong Cheng, N. Noinaj, Dan Yu, 2021, bioRxiv.

A direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferases.

Gang Zhang, S. Richardson, D. Peterson, 2015, Analytical biochemistry.

Nicotinamide N-methyltransferase (NNMT) upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes.

Jun Wang, Yuwei Jiang, Zhenyuan Song, 2021, American journal of physiology. Cell physiology.

A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16

William Arbuthnot Sir Lane, J. Lucchesi, Edwin R. Smith, 2006, Molecular and Cellular Biology.

Structure-Activity Relationship Studies on Cell-Potent Nicotinamide N-Methyltransferase Bisubstrate Inhibitors.

Tianqi Zhao, Rong Huang, Iredia D. Iyamu, 2023, Journal of medicinal chemistry.