Hua Zou

发表

Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.

M. Klein, Biching Sang, G. Snell, 2016, Journal of molecular biology.

Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure.

Biching Sang, A. Hata, T. Okawa, 2017, Journal of medicinal chemistry.

STRUCTURAL ANALYSIS OF THE MECHANISM OF INHIBITION AND ALLOSTERIC ACTIVATION OF THE KINASE DOMAIN OF HER 2

Toshimasa Tanaka, Biching Sang, J. Yano, 2011 .

Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.

Biching Sang, C. Mol, D. Dougan, 2011, Bioorganic & medicinal chemistry letters.

Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).

V. Feher, D. Hosfield, T. Kawamoto, 2013, Bioorganic & medicinal chemistry letters.

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

M. Klein, Biching Sang, T. Arita, 2016, Bioorganic & medicinal chemistry.

Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors.

Masaharu Nakayama, R. Skene, Masato Yoshida, 2020, Bioorganic & medicinal chemistry letters.

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate

M. Klein, Biching Sang, G. Snell, 2015, Nature Structural &Molecular Biology.

Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation*

E. Chien, D. Kassel, D. McRee, 2003, Journal of Biological Chemistry.

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase*

K. Wilson, Biching Sang, C. Mol, 2004, Journal of Biological Chemistry.

Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.

H. Kokubo, H. Oki, T. Taniguchi, 2017, Journal of medicinal chemistry.

Characterization of the two catalytic domains in histone deacetylase 6.

Biching Sang, M. Navre, Yiqin Wu, 2006, Biochemical and biophysical research communications.

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Yoshikazu Ohta, Tomoyasu Ishikawa, Andy Jennings, 2011, The Journal of Biological Chemistry.

Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors.

Yan Liu, Jeffrey Stafford, David Hosfield, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Mobocertinib, a Potent, Oral Inhibitor of EGFR Exon 20 Insertion Mutations in Non-Small Cell Lung Cancer.

T. Clackson, A. Gould, V. Rivera, 2022, Bioorganic & medicinal chemistry letters.

Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.

S. Aparicio, G. Morin, H. Kokubo, 2018, Journal of medicinal chemistry.

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.

M. Yoshikawa, K. Saikatendu, Y. Shimizu, 2018, Journal of medicinal chemistry.

Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.

Tomoaki Hasui, M. Fushimi, K. Saikatendu, 2019, Journal of medicinal chemistry.

The dynamic conformational landscape of the protein methyltransferase SETD8

Cheng Luo, Jian Jin, Yujun George Zheng, 2019, eLife.

The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8

Cheng Luo, Jian Jin, Hualiang Jiang, 2018, bioRxiv.

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

C.-H. Chen, Kenjiro Sato, D. Dougan, 2023, Journal of medicinal chemistry.

Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design

K. Saikatendu, Tsuyoshi Ishii, T. Wakabayashi, 2020, ACS omega.