Gérald Lelais

发表

Mixed β2/β3-Hexapeptides and β2/β3-Nonapeptides Folding to (P)-Helices with Alternating Twelve- and Ten-Membered Hydrogen-Bonded Rings

B. Jaun, D. Seebach, M. Rueping, 2002 .

Determination of zinc to beta-peptide binding constants with electrospray ionization mass spectrometry.

R. Zenobi, A. Wortmann, F. Rossi, 2005, Journal of mass spectrometry : JMS.

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.

P. McNamara, S. Joseph, R. Epple, 2014, Bioorganic & medicinal chemistry letters.

Zn2+-Complexation by a β-peptidic helix and hairpin containing β3hCys and β3hHis building blocks: Evidence from CD measurements preliminary communication

D. Seebach, F. Rossi, Gérald Lelais, 2003 .

Preparation of Protected β2‐ and β3‐Homocysteine, β2‐ and β3‐Homohistidine, and β2‐Homoserine for Solid‐Phase Syntheses

D. Seebach, F. Rossi, Gérald Lelais, 2004 .

Electrophilic S‐Trifluoromethylation of Cysteine Side Chains in α‐ and β‐Peptides: Isolation of Trifluoro‐methylated Sandostatin® (Octreotide) Derivatives

D. Seebach, S. Capone, Oliver Flögel, 2008 .

Modern strategies in organic catalysis: The advent and development of iminium activation

D. MacMillan, David W. C. MacMillan, Gérald Lelais, 2006 .

Synthesis, CD Spectra, and Enzymatic Stability of β2‐Oligoazapeptides Prepared from (S)‐2‐Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu

D. Seebach, Gérald Lelais, 2003 .

Beta2-amino acids-syntheses, occurrence in natural products, and components of beta-peptides1,2.

D. Seebach, Dieter Seebach, Gérald Lelais, 2004, Biopolymers.

β2-Amino Acids: Syntheses, Occurrence in Natural Products, and Components of β-Peptides

D. Seebach, Gérald Lelais, 2004 .

Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.

Laura J. Kingsley, S. Bender, M. Vaillancourt, 2021, Journal of medicinal chemistry.

Enantioselective Preparation of 2‐Aminomethyl Carboxylic Acid Derivatives: Solving the β2‐Amino Acid Problem with the Chiral Auxiliary 4‐Isopropyl‐5,5‐diphenyloxazolidin‐2‐one (DIOZ). Preliminary Communication

D. Seebach, L. Schaeffer, B. Schweizer, 2003 .

β‐Peptidic Secondary Structures Fortified and Enforced by Zn2+ Complexation – On the Way to β‐Peptidic Zinc Fingers?

B. Jaun, D. Seebach, A. Wortmann, 2006 .

History and Perspective of Chiral Organic Catalysts

D. MacMillan, Gérald Lelais, 2006 .

Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Ce

Chun Xing Li, S. Bender, G. Spraggon, 2016, Journal of medicinal chemistry.

Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors

Haikuo Zhang, Gerald Lelais, Kwok-Kin Wong, 2016 .

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.

J. Barretina, Jennifer L. Harris, J. Engelman, 2016, Cancer research.

Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.

Yingyao Zhou, K. Kuhen, J. Walker, 2020, Virology.

Development of a virtual reality platform for effective communication of structural data in drug discovery.

Laura J Kingsley, Vincent Brunet, Gerald Lelais, 2019, Journal of molecular graphics & modelling.

Abstract 2585: Discovery of a potent covalent mutant-selective EGFR inhibitor - the journey from high throughput screening to EGF816

C. Li, S. Kasibhatla, I. Matushansky, 2015 .

Abstract 1734:In vitrocharacterization of EGF816, a third-generation mutant-selective EGFR inhibitor

Jennifer L. Harris, S. Bender, N. Pathan, 2014 .

Abstract 1733: EGF816, a novel covalent inhibitor of mutant-selective epidermal growth factor receptor, overcomes T790M-mediated resistance in NSCLC

S. Bender, M. Vaillancourt, S. Kasibhatla, 2014 .

Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors

P. Jänne, Jennifer L. Harris, M. Eck, 2016, Nature.