I. Kii

发表

Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors.

M. Imanishi, J. Ohkanda, Wataru Nojo, 2020, Chemical communications.

Strain-promoted double-click reaction for chemical modification of azido-biomolecules.

M. Hagiwara, T. Hosoya, H. Uekusa, 2010, Organic & biomolecular chemistry.

A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach.

T. Hosoya, Harumi Ito, S. Yoshida, 2019, Chemical communications.

Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations.

T. Hosoya, Harumi Ito, S. Yoshida, 2020, Chemical communications.

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells.

T. Hosoya, Harumi Ito, S. Yoshida, 2018, Chemical communications.

Novel Methods for Efficient Conjugation of Two Azide Molecules

T. Hosoya, S. Yoshida, I. Kii, 2016 .

Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation.

T. Hosoya, Kenji Watanabe, Takashi Niwa, 2020, Organic letters.

Synthesis of Functionalized Dibenzoazacyclooctynes by a Decomplexation Method for Dibenzo-Fused Cyclooctyne-Cobalt Complexes.

T. Hosoya, Takashi Nishiyama, I. Kii, 2022, Organic letters.

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ

M. Hagiwara, T. Hosoya, Y. Okuno, 2015, Scientific Reports.

S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.

M. Hagiwara, Kei Iida, S. Iwata, 2021, Cell chemical biology.

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions.

M. Hagiwara, T. Hosoya, S. Yoshida, 2018, Chemical communications.

Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation

Kazuo Takakuda, Daisuke Sakai, Kazuki Nakagawa, 2011, PloS one.

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses.

M. Hagiwara, Kei Iida, N. Ito, 2014, The Journal of clinical investigation.

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.

M. Hagiwara, N. Ito, N. Kataoka, 2015, Bioorganic & medicinal chemistry.

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.

Nobutoshi Ito, Masatoshi Hagiwara, Hiroshi Onogi, 2010, Nature communications.

Druggable Transient Pockets in Protein Kinases

K. Umezawa, I. Kii, 2021, Molecules.

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

M. Hagiwara, K. Ohe, M. Matsuo, 2017, Scientific Reports.

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

M. Hagiwara, N. Ito, T. Ikura, 2015, Molecular Pharmacology.

Title Selective inhibition of the kinase DYRK 1 A by targeting itsfolding process

M. Hagiwara, H. Shibuya, N. Ito, 2019 .

Selective inhibition of the kinase DYRK1A by targeting its folding process

M. Hagiwara, H. Shibuya, N. Ito, 2016, Nature Communications.

Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.

T. Umehara, K. Umezawa, T. Hosoya, 2021, European journal of medicinal chemistry.

Title Identification of a DYRK 1 A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC 37 fused with Luciferase nanoKAZ

M. Hagiwara, T. Hosoya, Y. Okuno, 2018 .

Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

M. Hagiwara, T. Tanabe, M. Yoshimura, 2014, Molecular pain.

Title Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration

M. Hagiwara, N. Ito, T. Ikura, 2018 .

Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity

K. Iwaisako, M. Hagiwara, M. Toi, 2017, Cancer Immunology, Immunotherapy.

Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision.

N. Hayashi, F. Ishikawa, T. Hosoya, 2017, Journal of the American Chemical Society.

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY.

T. Hosoya, Takashi Niwa, J. Ohkanda, 2022, Protein expression and purification.

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

M. Hagiwara, T. Awaya, T. Hosoya, 2017, Proceedings of the National Academy of Sciences.