Christopher Phillips

发表

Structural Basis for Targeting the Folded P-Loop Conformation of c-MET

C. Stubbs, I. Dale, U. Börjesson, 2020, ACS medicinal chemistry letters.

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

A. Gavin, C. Stubbs, M. Katan, 2020, EBioMedicine.

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.

Doyle J Cassar, Nichola L. Davies, J. Breed, 2022, Journal of medicinal chemistry.

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547.

A. Berns, L. Wessels, Paul D. Smith, 2018, Cancer research.

Structural Basis for Targeting the Folded P-Loop Conformation of c-MET

C. Stubbs, I. Dale, U. Börjesson, 2020, ACS medicinal chemistry letters.

Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors

E. Hennessy, C. Koh, C. Stubbs, 2019, ACS medicinal chemistry letters.

Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor

E. Hennessy, T. Moss, C. Stubbs, 2023, Journal of medicinal chemistry.

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.

Doyle J Cassar, Nichola L. Davies, J. Breed, 2023, Journal of medicinal chemistry.

Structure-based design and pharmacokinetic optimization of covalent allosteric inhibitors of the mutant GTPase KRASG12C.

Doyle J Cassar, J. Breed, D. Ogg, 2020, Journal of medicinal chemistry.