Paul J. Kleindl

发表

Ligand‐Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues

P. Low, Mini Thomas, S. Kularatne, 2009, Annals of the New York Academy of Sciences.

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide.

H. Santhapuram, C. Leamon, I. Vlahov, 2006, Bioorganic & medicinal chemistry letters.

Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.

H. Santhapuram, C. Leamon, I. Vlahov, 2011, Bioorganic & medicinal chemistry letters.

Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.

Soong-Hoon Kim, F. Lee, H. Santhapuram, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate.

J. Reddy, C. Leamon, I. Vlahov, 2006, Bioconjugate chemistry.

Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.

J. Reddy, C. Leamon, Le-cun Xu, 2007, Cancer research.

Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus

P. Low, Kevin K. W. Wang, H. Santhapuram, 2015, Molecular medicine.

Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate.

J. Reddy, Kevin K. W. Wang, C. Leamon, 2019, Bioconjugate chemistry.

Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate.

Hanna F. Klein, J. Reddy, Kevin K. W. Wang, 2020, Bioorganic & medicinal chemistry letters.

Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.

J. Reddy, H. Santhapuram, C. Leamon, 2014, Bioconjugate chemistry.

An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid.

J. Reddy, H. Santhapuram, C. Leamon, 2007, The Journal of organic chemistry.

Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates.

Hanna F. Klein, J. Reddy, Kevin K. W. Wang, 2017, Bioconjugate chemistry.

Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes

L. Wheeler, A. D. da Cunha, Y. Lu, 2021, Cell reports. Medicine.

Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors

I. Vlahov, Fei You, Paul J. Kleindl, 2011 .

Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates.

H. Santhapuram, C. Leamon, I. Vlahov, 2010, The Journal of organic chemistry.

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

J. Reddy, H. Santhapuram, C. Leamon, 2018, Scientific Reports.

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

J. Reddy, H. Santhapuram, C. Leamon, 2018, Scientific Reports.

Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs.

J. Reddy, C. Leamon, I. Vlahov, 2011, Bioorganic & Medicinal Chemistry Letters.

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides.

C. Leamon, I. Vlahov, Paul J. Kleindl, 2008, Bioorganic & medicinal chemistry letters.