Hartmut Jaeschke

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Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action.

Thomas Hartung, Imran Shah, Jennifer Seed, 2014, ALTEX.

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver☆

Hartmut Jaeschke, H. Jaeschke, W. Ding, 2013, Redox biology.

Acetaminophen-induced Liver Injury: from Animal Models to Humans

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2014, Journal of clinical and translational hepatology.

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

Hartmut Jaeschke, H. Jaeschke, A. Ramachandran, 2012, Liver international : official journal of the International Association for the Study of the Liver.

Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2018, Expert review of molecular diagnostics.

Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

Hartmut Jaeschke, H. Jaeschke, Mary Lynn Bajt, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2012, The Journal of clinical investigation.

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2011, Life sciences.

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

Hartmut Jaeschke, H. Jaeschke, 2011, Journal of gastroenterology and hepatology.

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2012, Toxicology and applied pharmacology.

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury.

Imran Shah, Brigitte Landesmann, Vera Rogiers, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2013, Toxicology and applied pharmacology.

Novel insight into mechanisms of cholestatic liver injury.

Hartmut Jaeschke, H. Jaeschke, B. Woolbright, 2012, World journal of gastroenterology.

Mechanistic Biomarkers in Liver Diseases

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2017 .

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2011, Hepatology.

Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

Hartmut Jaeschke, H. Jaeschke, M. Trauner, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange

Glen E. P. Ropella, Hartmut Jaeschke, Mitchell R. McGill, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice.

Hartmut Jaeschke, H. Jaeschke, A. Ramachandran, 2014, Toxicology letters.

Disruption of Estrogen Receptor Alpha in Rats Results in Faster Initiation of Compensatory Regeneration Despite Higher Liver Injury After Carbon Tetrachloride Treatment

Hartmut Jaeschke, Udayan Apte, H. Jaeschke, 2017, International journal of toxicology.

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

Victor R. Ambros, Hartmut Jaeschke, Isana Veksler-Lublinsky, 2014, Proceedings of the National Academy of Sciences.

Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.

Hartmut Jaeschke, H. Jaeschke, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Apoptosis and necrosis in liver disease

Hartmut Jaeschke, H. Jaeschke, M. Bajt, 2004, Liver international : official journal of the International Association for the Study of the Liver.

Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice.

Hartmut Jaeschke, H. Jaeschke, R. Jenkins, 2013, Toxicology and applied pharmacology.