T. Graf

发表

Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).

C. Pearce, N. Oberlies, D. Kroll, 2011, Journal of natural products.

Oberlies " Identification of Hepatoprotective Flavonolignans from Silymarin

Yanze, S. Polyak, V. Lohmann, 2015 .

Differential In Vitro Effects of Intravenous versus Oral Formulations of Silibinin on the HCV Life Cycle and Inflammation

J. Tavis, S. Polyak, N. Oberlies, 2011, PloS one.

Identification of hepatoprotective flavonolignans from silymarin

S. Polyak, V. Lohmann, S. Pal, 2010, Proceedings of the National Academy of Sciences.

DMD059451 1675..1683

N. Oberlies, B. Gufford, P. Lazarus, 2014 .

Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: Validation of their authenticity via in situ chemical analysis.

H. Raja, C. Pearce, N. Oberlies, 2017, RSC advances.

Dereplication of Macrocyclic Trichothecenes from Extracts of Filamentous Fungi through UV and NMR Profiles

C. Pearce, N. Oberlies, D. Kroll, 2010, The Journal of Antibiotics.

Conventional and accelerated‐solvent extractions of green tea (camellia sinensis) for metabolomics‐based chemometrics

N. Oberlies, J. Kellogg, N. Cech, 2017, Journal of pharmaceutical and biomedical analysis.

Pheophorbide Derivatives Isolated From Açaí Berries (Euterpea oleracea) Activate an Antioxidant Response Element In Vitro

N. Oberlies, G. Raner, Suneel K. Kandagatla, 2019, Natural product communications.

Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis).

N. Oberlies, N. Cech, Nadja B. Cech, 2011, Journal of natural products.

DMD052563 1662..1670

N. Oberlies, M. Paine, S. Brantley, 2013 .

Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Anemopsis californica).

A. Kaur, H. Raja, T. El-Elimat, 2015, Phytochemistry letters.

Sarothrin from Alkanna orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor

Scott A. Jarmusch, T. El-Elimat, N. Oberlies, 2013, Planta Medica.

Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).

S. Faeth, H. Raja, T. El-Elimat, 2014, Journal of natural products.

Delitpyrones: α-Pyrone Derivatives from a Freshwater Delitschia sp.

Rick L. Bunch, H. Raja, T. El-Elimat, 2018, Planta Medica.

A Mass Spectrometry-Based Assay for Improved Quantitative Measurements of Efflux Pump Inhibition

Daniel H. Foil, G. Kaatz, N. Cech, 2015, PloS one.

Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).

C. Day, H. Raja, T. El-Elimat, 2013, Journal of natural products.

Cytotoxic Xanthone-Anthraquinone Heterodimers from an Unidentified Fungus of the Order Hypocreales (MSX 17022)

S. Matthew, C. Pearce, N. Oberlies, 2011, The Journal of Antibiotics.

Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.

C. Pearce, N. Oberlies, D. Kroll, 2011, Tetrahedron letters.

Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria

S. Faeth, N. Oberlies, N. Cech, 2015, PloS one.

Production and purification of N-terminal half-transferrin in Pichia pastoris.

L. Steinlein, R. A. Ikeda, T. Graf, 1995, Protein expression and purification.

A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts.

S. Polyak, N. Oberlies, N. Cech, 2016, Journal of pharmaceutical and biomedical analysis.

Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention.

R. Agarwal, N. Oberlies, D. Kroll, 2007, Planta medica.

Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans

E. Dees, N. Oberlies, M. Paine, 2009, Drug Metabolism and Disposition.

Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

Nam-Cheol Kim, M. Wani, M. Wall, 2003, Organic & biomolecular chemistry.

HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.

N. Oberlies, J. Napolitano, J. McAlpine, 2013, The Journal of organic chemistry.

Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

Nam-Cheol Kim, M. Wani, M. Wall, 2003, Organic & biomolecular chemistry.

Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Dongho Lee, Nicholas H Oberlies, Joseph O Falkinham, 2004, Journal of natural products.

A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.

A. Kinghorn, Dongho Lee, N. Oberlies, 2005, Organic letters.

Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides

N. Oberlies, B. Gufford, M. Paine, 2015, Drug Metabolism and Disposition.

Interaction of Arsenate with the Molybdenum Site of Sulfite Oxidase

R. Prince, K. Rajagopalan, G. George, 1998 .

Optimization of expression of human sulfite oxidase and its molybdenum domain.

K. Rajagopalan, T. Graf, C. A. Temple, 2000, Archives of biochemistry and biophysics.

Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme.

K. Rajagopalan, J. Johnson, R. Garrett, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris.

H. Raja, T. El-Elimat, C. Pearce, 2015, European journal of organic chemistry.

Multiple effects of silymarin on the hepatitis C virus lifecycle

J. Tavis, Y. Nahmias, S. Polyak, 2010, Hepatology.

Structural Insights into Sulfite Oxidase Deficiency*

C. Kisker, K. Rajagopalan, H. Wilson, 2005, Journal of Biological Chemistry.

Isolated sulfite oxidase deficiency: review of two cases in one family.

I. MacDonald, K. Rajagopalan, J. Johnson, 1999, Ophthalmology.

Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach

H. Raja, C. Pearce, N. Oberlies, 2017, Journal of natural products.

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae

C. Pearce, N. Oberlies, M. Figueroa, 2012, The Journal of Antibiotics.

Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.

S. Matthew, C. Pearce, N. Oberlies, 2011, Journal of natural products.

Silymarin Prevents Memory Impairments, Anxiety, and Depressive-Like Symptoms in a Rat Model of Post-Traumatic Stress Disorder

M. M. Abualsamen, T. El-Elimat, N. Oberlies, 2018, Planta Medica.

Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).

Jeanine M. Davis, N. Oberlies, M. Andrews, 2007, Journal of agricultural and food chemistry.

Bioactive constituents of the stem bark of Mitrephora glabra.

A. Kinghorn, Dongho Lee, N. Oberlies, 2009, Journal of natural products.

Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.

Eunkyung Kim, N. Oberlies, M. Paine, 2011, Planta medica.

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study

O. Kvalheim, N. Oberlies, J. Kellogg, 2017, Journal of natural products.

Synthesis of poly(1,2-glycerol carbonate)–paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03501b

Daniel H. Foil, M. Grinstaff, Y. Colson, 2017, Chemical science.

A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors

N. Oberlies, M. Paine, S. Brantley, 2013, Drug Metabolism and Disposition.

Delivery of eupenifeldin via polymer-coated surgical buttresses prevents local lung cancer recurrence.

M. Grinstaff, Y. Colson, Y. Hung, 2021, Journal of controlled release : official journal of the Controlled Release Society.

The Chemistry of Kratom [Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids.

Joshua J. Kellogg, H. Raja, N. Oberlies, 2020, Journal of natural products.

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

R. Agarwal, N. Oberlies, D. Kroll, 2005, Cancer research.

Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

N. Oberlies, B. Gufford, D. J. Fediuk, 2014, CPT: pharmacometrics & systems pharmacology.

Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

R. Agarwal, N. Oberlies, D. Kroll, 2010, Planta medica.

Large-scale Isolation of Flavonolignans from Silybum marianum ( Milk Thistle ) Extract Affords New Minor Constituents and Preliminary Structure-Activity Relationships

N. Oberlies, D. Kroll, Rajesh, 2010 .

Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.

S. Polyak, Denise M. Paschal, N. Oberlies, 2010, Gastroenterology.

Enhanced bioactivity of silybin B methylation products.

R. Agarwal, S. Polyak, N. Oberlies, 2013, Bioorganic & medicinal chemistry.

Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin‐drug interactions

N. Oberlies, M. Paine, Katherine D. Lynch, 2021, Phytotherapy research : PTR.

Drug Leads from Endophytic Fungi: Lessons Learned via Scaled Production

H. Raja, N. Oberlies, J. Rivera-Chávez, 2020, Planta Medica.

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

H. Raja, N. Oberlies, S. Hemby, 2020, Scientific Reports.

BASIC—LIVER, PANCREAS, AND BILIARY TRACT Silymarin Inhibits In Vitro T-Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection

S. Polyak, Denise M. Paschal, N. Oberlies, 2010 .

Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation

N. Oberlies, B. Gufford, P. Lazarus, 2014, Drug Metabolism and Disposition.

Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.

S. Polyak, N. Oberlies, B. Gufford, 2013, Bioorganic & medicinal chemistry.

Evaluating the Antioxidant Properties of the Ancient-Crop Tef (Eragrostis tef) Grain Extracts in THP-1 Monocytes

N. Oberlies, Z. Jia, L. Flores-Bocanegra, 2023, Antioxidants.

What was old is new again: Phenotypic screening of a unique fungal library yields pyridoxatin, a promising lead against extensively resistant Acinetobacter baumannii (AB5075).

H. Raja, C. Pearce, N. Oberlies, 2023, Phytochemistry letters.

Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice

N. Oberlies, N. Cech, M. Paine, 2023, Drug Metabolism and Disposition.

Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides

N. Oberlies, B. Gufford, M. Paine, 2015, Drug Metabolism And Disposition.

HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.

N. Oberlies, J. Napolitano, J. McAlpine, 2013, The Journal of organic chemistry.

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae

C. Pearce, N. Oberlies, M. Figueroa, 2012, The Journal of Antibiotics.

Pharmacokinetic Effects of Different Models of Nonalcoholic Fatty Liver Disease in Transgenic Humanized OATP1B Mice

John D. Clarke, N. Oberlies, Katherine D. Lynch, 2024, Drug Metabolism and Disposition.

Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: Validation of their authenticity via in situ chemical analysis.

H. Raja, C. Pearce, N. Oberlies, 2017, RSC advances.

Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice.

John D. Clarke, N. Oberlies, Katherine D. Lynch, 2024, Pharmaceutical research.

Silymarin Prevents Memory Impairments, Anxiety, and Depressive-Like Symptoms in a Rat Model of Post-Traumatic Stress Disorder

M. M. Abualsamen, T. El-Elimat, N. Oberlies, 2018, Planta Medica.