Masashi Asai

发表

Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells.

H. Hamada, F. Uchiumi, S. Tanuma, 2019, International journal of oncology.

Alzheimer Amyloid α‐Secretase: A Special Target for Drug Development

B. Szabó, S. Ishiura, N. Sasagawa, 2001 .

PT608. Analysis of glutamate-induced processing of proline-rich transmembrane protein 2 (PRRT2)

Y. Yazır, Hiroki Ozawa, E. Karson, 2016, International Journal of Neuropsychopharmacology.

PT608. Analysis of glutamate-induced processing of proline-rich transmembrane protein 2 (PRRT2)

Hiroki Ozawa, N. Iwata, N. Kurotaki, 2016, International Journal of Neuropsychopharmacology.

Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer's Disease.

N. Iwata, S. Kimura, K. Maruyama, 2016, Biological & pharmaceutical bulletin.

Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts.

N. Iwata, K. Shirotani, Masashi Asai, 2017, Biological & pharmaceutical bulletin.

Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia

K. Okumura, T. Murohara, Y. Oshida, 2014, Nature Communications.

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.

S. Kitazume, T. Saido, Y. Kiso, 2004, Bioorganic & medicinal chemistry letters.

Putative function of ADAM9, ADAM10, and ADAM17 as APP -secretase

B. Szabó, S. Ishiura, N. Sasagawa, 2003 .

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.

B. Szabó, S. Ishiura, N. Sasagawa, 2003, Biochemical and biophysical research communications.

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.

Katsuhiro Yoshikawa, Takashi Asada, Takashi Aoi, 2013, Cell stem cell.

Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

H. Hioki, T. Kaneko, S. Yamanaka, 2011, PloS one.

A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs).

Y. Sunada, H. Inoue, S. Ohtsuki, 2017, Journal of biochemistry.

Anti-A b Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer ’ s Disease

H. Hioki, T. Kaneko, S. Yamanaka, 2011 .

Efficient four‐drug cocktail therapy targeting amyloid‐β peptide for Alzheimer's disease

T. Iwatsubo, T. Saido, N. Iwata, 2010, Journal of neuroscience research.

A new bathyal tubulanid nemertean, Tubulanus izuensis sp. nov. (Nemertea: Palaeonemertea), from Japanese waters

H. Nakano, H. Kajihara, Taeko Kimura, 2020, Proceedings of the Biological Society of Washington.

Introductory Chapter: Gene Expression Controlling System and Its Application to Medical Sciences

F. Uchiumi, Masashi Asai, 2018, Gene Expression and Control.

An NAD+ dependent/sensitive transcription system: Toward a novel anti-cancer therapy

F. Uchiumi, S. Tanuma, Akira Sato, 2020 .

BACE1 interacts with nicastrin.

T. Saido, Y. Kino, S. Ishiura, 2002, Biochemical and biophysical research communications.

Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion.

T. Saido, N. Iwata, S. Ishiura, 2007, Biochemical and biophysical research communications.

An alternative metabolic pathway of amyloid precursor protein C‐terminal fragments via cathepsin B in a human neuroglioma model

T. Saido, N. Iwata, S. Ishiura, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

1,3-Capryloyl-2-arachidonoyl glycerol activates α-secretase activity and suppresses Aβ40 secretion in A172 cells

E. Futai, S. Ishiura, N. Sasagawa, 2009, Neuroscience Letters.

BACE1 interacts with lipid raft proteins

S. Mizutani, T. Saido, S. Ishiura, 2006, Journal of neuroscience research.

Characterization of the human E2F4 promoter region and its response to 12-O-tetradecanoylphorbol-13-acetate.

H. Hamada, F. Uchiumi, S. Tanuma, 2019, Journal of biochemistry.

The novel β‐secretase inhibitor KMI‐429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild‐type mice

B. Szabó, T. Saido, Y. Kiso, 2006 .

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.

B. Szabó, T. Saido, Y. Kiso, 2006, Journal of neurochemistry.

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

M. Staufenbiel, M. Higuchi, S. Muramatsu, 2013, Scientific Reports.

Title Global brain delivery of neprilysin gene by intravascular administration ofAAV vector in mice

M. Staufenbiel, M. Higuchi, S. Muramatsu, 2019 .

oMolecular Profiling of Ginsenoside Metabolites to Identify Estrogen Receptor Alpha Activity.

Y. Uesawa, H. Sone, Jing Yu, 2021, Gene.

Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients.

N. Iwata, Masashi Asai, T. Kawakubo, 2017, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease.

N. Iwata, K. Shirotani, Masashi Asai, 2017, Journal of biochemistry.

APP α-Secretase, a Novel Target for Alzheimer Drug Therapy

S. Ishiura, N. Sasagawa, S. Tanuma, 2013 .

Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer's Disease.

N. Iwata, K. Maruyama, K. Shirotani, 2016, Biological & pharmaceutical bulletin.