R. Desai

发表

Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor

N. Srinivas, P. Giri, Sanjay Singh, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

A sensitive assay for ZYAN1 in human whole blood and urine utilizing positive LC-MS/MS electrospray ionization.

H. Patel, N. Srinivas, P. Patel, 2017, Bioanalysis.

Identification of Novel and Selective KV2 Channel Inhibitors

O. McManus, J. Herrington, L. Kiss, 2011, Molecular Pharmacology.

Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors.

D. Bandyopadhyay, H. Patel, R. Bahekar, 2020, Bioorganic chemistry.

ZYKR1, a novel, potent, and peripherally selective kappa opioid receptor agonist reduces visceral pain and pruritus in animal models.

D. Bandyopadhyay, P. Patel, Mukul R Jain, 2022, European journal of pharmacology.

Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors.

D. Bandyopadhyay, R. Bahekar, Dipam N Patel, 2019, Bioorganic & medicinal chemistry letters.

A COMPARATIVE SAR AND COMPUTER MODELING STUDY OF BENZISOTHIAZOLONE, MECHANISM-BASED INHIBITORS WITH PORCINE PANCREATIC AND HUMAN LEUKOCYTE ELASTASE

D. Hlasta, J. Court, Jian Shen, 1996 .

The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase

R. Gordon, A. Rowlands, D. Hlasta, 1995 .

ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer

D. Bandyopadhyay, Rajiv Sharma, N. Srinivas, 2020, Pharmacology research & perspectives.

Delcaroline, a Novel Alkaloid from Delphinium carolinianum Walt.

S. Pelletier, R. Desai, N. V. Mody, 1981 .

Pharmacological characterization of ZYDPLA1, a novel long‐acting dipeptidyl peptidase‐4 inhibitor

H. Patel, Mukul R Jain, P. Jadav, 2015, Journal of diabetes.

Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?– Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model

H. Patel, P. Patel, Nirav Modi, 2017, Drug Research.

(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

The synthesis of substituted saccharins through the o-lithiative sulfonamidation of N,N-diethylbenzamides

D. Hlasta, J. Court, R. Desai, 1991 .

Formation of C-glycosides by polarity inversion at the anomeric centre

S. Hanessian, R. Desai, M. Martin, 1986 .

Synthesis of chiral β-methyl tryptamine-derived GnRH antagonists

M. Goulet, J. Simeone, M. Ponpipom, 2001 .

Synthesis of (.+-.)-isocelorbicol

J. Huffman, R. Desai, G. F. Hillenbrand, 1984 .

A Procedure for Alcohol Inversion Using Cesium Acetate

J. Huffman, R. Desai, 1983 .

Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses.

Sachchidanand, Sanjay Kumar, Rajiv Sharma, 2018, Journal of medicinal chemistry.

Design and synthesis of potent and subtype-selective PPARα agonists

J. Berger, D. Moller, S. Wright, 2006 .

In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes.

C. Hop, R. Franklin, Jianmei Pang, 2005, Journal of pharmaceutical and biomedical analysis.

Nonclinical Pharmacokinetic Evaluation of Desidustat: a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia

H. Patel, P. Patel, Nirav Modi, 2022, European Journal of Drug Metabolism and Pharmacokinetics.

Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases.

Mukul R Jain, A. Joharapurkar, V. Patel, 2018, Journal of medicinal chemistry.

Pharmacological Characterization of ZYAN1, a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia

A. Joharapurkar, V. Patel, S. Kshirsagar, 2015, Drug Research.

Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia

H. Patel, P. Patel, N. Srinivas, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1

H. Patel, P. Patel, N. Srinivas, 2018, Cancer Chemotherapy and Pharmacology.

An Efficient and Scalable Synthesis of tert-Butyl (3aR,6aS)-5-Oxohexahydrocyclo penta[c]pyrrole-2(1H)-carboxylate: A Pharmacologically Important Intermediate

P. Jadav, R. Bahekar, Dipam N Patel, 2017 .

Recent Developments in HIF Prolyl Hydroxylase Inhibitors

Mukul R Jain, A. Joharapurkar, R. Desai, 2015 .

Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I)

D. Hlasta, D. C. Bode, P. Silver, 1997 .

Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor.

D. Bandyopadhyay, Mukul R Jain, P. Giri, 2022, Bioorganic & Medicinal Chemistry Letters.

THE PYRODELPHONINE CHROMOPHORE. CRYSTAL STRUCTURES OF PYRODELPHININE AND DELPHININE

J. Finer-Moore, S. Pelletier, R. Desai, 1982 .

Alkoxy substituted benzisothiazolone (BIT) derivatives: potent inhibitors of human leukocyte elastase

R. Gordon, D. Hlasta, E. Ferguson, 1995 .

Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist.

H. Patel, Suresh R. Giri, Mukul R Jain, 2016, ACS medicinal chemistry letters.

A Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist Demonstrates Favorable Effects on Lipid Homeostasis

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

5-Aryl thiazolidine-2,4-diones: Discovery of PPAR dual α/γ agonists as antidiabetic agents

J. Berger, D. Moller, T. Doebber, 2003 .

ZY15557, a novel, long acting inhibitor of dipeptidyl peptidase‐4, for the treatment of Type 2 diabetes mellitus

H. Patel, Mukul R Jain, P. Jadav, 2017, British journal of pharmacology.

Sensitive and specific LC-ESI-MS/MS method for determination of ZYDPLA1, a novel long-acting dipeptidyl peptidase 4 inhibitor in rat plasma: An application for toxicokinetic study in rats.

H. Patel, N. Srinivas, R. Bahekar, 2017, Biomedical chromatography : BMC.

Biological activity of WIN 63759, an orally bioavailable inhibitor of human neutrophil elastase

D. Hlasta, A. Maycock, J. Newton, 1995 .

Phosphonates and phosphinates: novel leaving groups for benzisothiazolone inhibitors of human leukocyte elastase.

R. Gordon, D. Hlasta, E. Ferguson, 1995, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel pyrazolo-pyrimidin-amines as potent and selective BTK inhibitors.

D. Bandyopadhyay, Mukul R Jain, P. Jadav, 2022, Bioorganic chemistry.

SYNTHESIS OF AGAROFURANS BY CYCLIZATION OF 10‐EPIEUDESMENE‐3,11‐DIOLS

J. Huffman, R. Desai, 1983 .

Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist.

D. Bandyopadhyay, Suresh R. Giri, Mukul R Jain, 2016, ACS medicinal chemistry letters.

Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists

J. Berger, D. Moller, T. Doebber, 2003 .

Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase.

R. Gordon, D. Hlasta, W. Eickhoff, 1995, Journal of medicinal chemistry.

A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase

D. Hlasta, M. Bell, J. Court, 1994 .