Sen Zhang

发表

IL-23/IL-23R: potential mediator of intestinal tumor progression from adenomatous polyps to colorectal carcinoma

Kai Li, Jie Zhang, P. Lin, 2011, International Journal of Colorectal Disease.

Generation of a long-acting fusion inhibitor against HIV-1.

Xiao-Wen Fan, Ye Guo, Panpan Zhou, 2018, MedChemComm.

Abstract 1794: AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC

T. Clackson, R. Anjum, V. Rivera, 2012 .

Targeted blockade of JAK/STAT3 signaling inhibits proliferation, migration and collagen production as well as inducing the apoptosis of hepatic stellate cells.

Wei Wei, Wu-Yi Sun, Sen Zhang, 2016, International journal of molecular medicine.

The emerging roles of β-arrestins in fibrotic diseases

Wei Wei, Wu-Yi Sun, Jing-jing Wu, 2015, Acta Pharmacologica Sinica.

Picroside I inhibits asthma phenotypes by regulating Tbet/ GATA-3 ratio and Th1/Th2 balance in a murine model of asthma

H. Qin, Yuemei Lu, Jinhong Zheng, 2018, Tropical Journal of Pharmaceutical Research.

Downregulation of long noncoding RNA HCP5/miR-216a-5p/ZEB1 axis inhibits the malignant biological function of laryngeal squamous cell carcinoma cells

Yujun Li, Lina Wu, Qinli Zhao, 2022, Frontiers in Immunology.

A standardized extract from Paeonia lactiflora and Astragalus membranaceus induces apoptosis and inhibits the proliferation, migration and invasion of human hepatoma cell lines.

Wei Wei, Wu-Yi Sun, Jing-jing Wu, 2013, International journal of oncology.

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

T. Clackson, R. Anjum, V. Rivera, 2016, Clinical Cancer Research.

Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066)

T. Clackson, R. Anjum, V. Rivera, 2010 .

Abstract #3738: Discovery of potent and selective orally active inhibitors of anaplastic lymphoma kinase (ALK)

T. Clackson, R. Anjum, V. Rivera, 2009 .

Huaier Extract Inhibits Proliferation and Promotes Apoptosis via the MAPK Pathway in Human Osteosarcoma Cells

Minqi Li, Dongfang Li, T. Hasegawa, 2021 .

Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines

Kailin Xu, Zhen-Yu Li, Qing-yun Wu, 2022, Cellular Oncology.

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.

T. Clackson, R. Anjum, V. Rivera, 2016, Journal of medicinal chemistry.

Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents

Guang Zhou, Sen Zhang, Shuaibing Liu, 2016, Scientific Reports.

Corrigendum: Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Jing Zhang, Sang Hyun Lee, Lei Zhang, 2016, Nature.

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

M. Loda, S. Signoretti, Pixu Liu, 2008, Nature.

Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer.

Kwok-Kin Wong, T. Clackson, A. Gould, 2021, Cancer discovery.

Crizotinib-Resistant Mutants of EML4-ALK Identified Through an Accelerated Mutagenesis Screen

T. Clackson, R. Anjum, V. Rivera, 2011, Chemical biology & drug design.

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.

T. Clackson, V. Rivera, T. Zhou, 2013, Journal of medicinal chemistry.

Induction of Apoptosis by Matrine Derivative ZS17 in Human Hepatocellular Carcinoma BEL-7402 and HepG2 Cells through ROS-JNK-P53 Signalling Pathway Activation

Lisheng Wang, Ke-qi Han, Xu Liu, 2022, International journal of molecular sciences.

Discovery of Mobocertinib, a Potent, Oral Inhibitor of EGFR Exon 20 Insertion Mutations in Non-Small Cell Lung Cancer.

T. Clackson, A. Gould, V. Rivera, 2022, Bioorganic & medicinal chemistry letters.

Roles of T875N somatic mutation in the activity, structural stability of JAK2 and the transformation of OCI-AML3 cells.

Kailin Xu, L. Zeng, Jiang Cao, 2019, International journal of biological macromolecules.

Disruption of R867 and Y613 interaction plays key roles in JAK2 R867Q mutation caused acute leukemia.

Kailin Xu, L. Zeng, Zhen-Yu Li, 2019, International journal of biological macromolecules.

Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid tumors

K. Papadopoulos, A. Naing, S. Piha-Paul, 2020, Journal for ImmunoTherapy of Cancer.

Decreased expression of the type III TGF-β receptor enhances metastasis and invasion in hepatocellullar carcinoma progression.

Wei Wei, Wu-Yi Sun, Jing-jing Wu, 2016, Oncology reports.

Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts

Xiaojun Liu, Jie Xiao, Xiao-ping Ji, 2015, PloS one.

Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway

Q. Du, Aimin Wang, Ziming Wang, 2021, Experimental and therapeutic medicine.

Abstract 781: The potent ALK inhibitor AP26113 can overcome mechanisms of resistance to first- and second-generation ALK TKIs in preclinical models

J. Hodgson, V. Rivera, Scott D. Wardwell, 2015 .

Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor.

Kai Li, Bo Gao, Jun Li, 2013, Carcinogenesis.

Detection of KIT mutants in circulating tumor DNA (ctDNA) and their association with ponatinib anti-tumor activity in patients (pts) with advanced gastrointestinal stromal tumors (GIST).

J. Hodgson, J. Fletcher, G. Demetri, 2015 .

Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2

Guangbiao Zhou, Lichuan Wu, Gui-zhen Wang, 2016, Oncotarget.

Loss of K607 and E877 interaction is a key reason for JAK2 K607N mutation caused acute myeloid leukemia.

Kailin Xu, L. Zeng, Zhen-Yu Li, 2019, International journal of biological macromolecules.

Abstract 3623: Efficacy and pharmacodynamic analysis of AP26113, a potent and selective orally active inhibitor of Anaplastic Lymphoma Kinase (ALK)

Juan J. Miret, Wei-Sheng Huang, Shuangying Liu, 2010 .

Water soluble chitosans shows anti-cancer effect in mouse H 22 liver cancer by enhancing the immune response

Yanqin Cheng, Weihong Liu, Liyan Zhao, 2016 .

[Interleukin 23 promotes lung adenocarcinoma a549 cell migration and invasion].

Jun Li, Jie Zhang, P. Lin, 2012, Zhongguo fei ai za zhi = Chinese journal of lung cancer.

Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models

V. Rivera, T. Zhou, M. Greenfield, 2016 .

Decreased expression of the type III TGF-β receptor enhances metastasis and invasion in hepatocellullar carcinoma progression.

Wei Wei, Wu-Yi Sun, Jing-jing Wu, 2016, Oncology reports.

Abstract 2827: Discovery of AP26113, a potent, orally active inhibitor of anaplastic lymphoma kinase and clinically relevant mutants

T. Clackson, V. Rivera, W. Shakespeare, 2015 .