Frederike Schmidt

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

J. Scheller, S. Rose-John, A. Tholey, 2017, Scientific Reports.

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration

A. Tholey, T. Koudelka, M. Stirnberg, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains

W. Annaert, D. Schmidt-Arras, O. Janssen, 2016, Biological chemistry.

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.

W. Annaert, D. Schmidt-Arras, O. Janssen, 2016, Biological chemistry.

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R

S. Sebens, C. Garbers, C. Becker-Pauly, 2021, Frontiers in Molecular Biosciences.

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.

S. Rose-John, M. Schäfers, D. Kalinin, 2016, Journal of medicinal chemistry.

The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2

M. Gütschow, O. Merkel, J. Walter, 2016, Biological chemistry.

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.

M. Gütschow, A. Tholey, T. Koudelka, 2015, The Biochemical journal.

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.

P. Rosenstiel, S. Rose-John, A. Tholey, 2017, Oncotarget.

Calcium negatively regulates meprin β activity and attenuates substrate cleavage

C. Pietrzik, C. Becker-Pauly, Friederike Zunke, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.