C. O’Connor

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Microsoft Word-SHMT2 Pharmacodynamics Manuscript final 10-7-19 FINAL

L. Matherly, M. Hüttemann, Z. Hou, 2019 .

Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.

L. Matherly, Z. Hou, L. Polin, 2018, Journal of medicinal chemistry.

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates

L. Matherly, Z. Hou, L. Polin, 2017, Molecular Cancer Therapeutics.

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

L. Matherly, Z. Hou, L. Polin, 2022, Scientific Reports.

Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

L. Matherly, Z. Hou, L. Polin, 2018, Journal of medicinal chemistry.

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

C. Dann, H. Xu, L. Matherly, 2016, Journal of medicinal chemistry.

6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.

C. Dann, L. Matherly, Z. Hou, 2015, Journal of medicinal chemistry.

Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

J. Rabinowitz, C. Dann, X. Bao, 2019, Molecular Cancer Therapeutics.

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

C. Dann, G. Garcia, X. Bao, 2021, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.

M. Spaller, Zhigang Liu, I. Kovari, 2013, Biochemical and biophysical research communications.

Design , synthesis and evaluation of a potent substrate-analog peptide-inhibitor identified by scanning Ala / Phe chemical mutagenesis

M. Spaller, Zhigang Liu, I. Kovari, 2013 .

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

L. Matherly, M. Hüttemann, Z. Hou, 2019, Molecular Pharmacology.