K. Lehtimäki

发表

A multimodal approach to identify clinically relevant biomarkers to comprehensively monitor disease progression in a mouse model of pediatric neurodegenerative disease

Tyler B. Johnson, T. Bragge, Pekka Poutiainen, 2020, Progress in Neurobiology.

A multimodal approach to identify clinically relevant parameters to monitor disease progression in a preclinical model of neuropediatric disease

Tyler B. Johnson, T. Bragge, J. Weimer, 2019, bioRxiv.

Progressive Volume Loss and White Matter Degeneration in Cstb-Deficient Mice: A Diffusion Tensor and Longitudinal Volumetry MRI Study

O. Gröhn, K. Lehtimäki, A. Lehesjoki, 2014, PloS one.

Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development

F. Marincola, D. L. Taylor, J. Berzofsky, 2017, Journal of Translational Medicine.

An in vivo accelerated developmental myelination model for testing promyelinating therapeutics

T. Bragge, D. Leonoudakis, D. Wilson, 2022, BMC neuroscience.

Effect of Ibuprofen on Skeletal Muscle of Dysferlin-Null Mice

Jace W. Jones, M. Kane, R. Bloch, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Systemic Delivery of Dysferlin Overlap Vectors Provides Long-Term Gene Expression and Functional Improvement for Dysferlinopathy

J. Mendell, L. Rodino‐Klapac, R. Potter, 2017, Human gene therapy.

Identification of mobile cholesterol compounds in experimental gliomas by 1H MRS in vivo: Effects of ganciclovir‐induced apoptosis on lipids

M. Ala-Korpela, J. Hakumäki, T. Liimatainen, 2006, FEBS letters.

Hip region muscular dystrophy and emergence of motor deficits in dysferlin‐deficient Bla/J mice

I. Richard, M. Hirsch, R. Nonneman, 2017, Physiological reports.

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

D. Surmeier, C. Halldin, A. Varrone, 2019, Nature Medicine.

Stem cell profiling by nuclear magnetic resonance spectroscopy

P. V. van Zijl, J. Gearhart, J. Hakumäki, 2006, Magnetic resonance in medicine.

White matter degeneration with Unverricht-Lundborg progressive myoclonus epilepsy: a translational diffusion-tensor imaging study in patients and cystatin B-deficient mice.

M. Könönen, R. Vanninen, R. Kälviäinen, 2013, Radiology.

The Visual Analog Scale in Multiple‐Dose Evaluations of Analgesics

R. Happonen, H. Quiding, K. Lehtimäki, 1981, Journal of clinical pharmacology.

Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat

Teemu Laitinen, Alejandra Sierra, Asla Pitkänen, 2011, Brain Structure and Function.

Using a State-of-the-Art Toolbox to Evaluate Molecular and Functional Readouts of Antisense Oligonucleotide-Induced Exon Skipping in mdx Mice

T. Bragge, N. Datson, J. V. van Deutekom, 2019, Nucleic acid therapeutics.

C57BL6 mouse substrains demonstrate differences in susceptibility to the demyelinating effects of Cuprizone toxin

Sophia Bardehle, T. Rosahl, Binod Jacob, 2020, bioRxiv.

Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment

Hilkka Soininen, Mervi Könönen, Miia Kivipelto, 2011, Neurobiology of Aging.

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

Jack R Glaser, Jack R. Glaser, Jukka Puoliväli, 2012, PloS one.

Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of Mutant Huntingtin Protein But Is Not Necessary for Production of a 586 Amino Acid Proteolytic Fragment

Pasi I. Tuunanen, L. Ellerby, L. Menalled, 2012, The Journal of Neuroscience.

Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models

Christer Halldin, Mei Kwan, Andrea Varrone, 2016, Neuron.

mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

Teemu Laitinen, Carol A. Colton, Juho Oksman, 2014, Journal of neuropathology and experimental neurology.

Cognitive disturbances in the cuprizone model of multiple sclerosis

M. Kopanitsa, A. Shatillo, P. Sweeney, 2020, Genes, brain, and behavior.

Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

J. Wityak, A. Airaksinen, L. Park, 2019, EJNMMI Radiopharmacy and Chemistry.

Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death.

R. Kauppinen, A. Pitkänen, J. Griffin, 2003, Cancer research.

Assignment of 1 H Nuclear Magnetic Resonance Visible Polyunsaturated Fatty Acids in BT 4 C Gliomas Undergoing Ganciclovir-Thymidine Kinase Gene Therapy-induced Programmed Cell Death 1

R. Kauppinen, A. Pitkänen, J. Griffin, 2003 .

Metabolite Changes in BT4C Rat Gliomas Undergoing Ganciclovir-Thymidine Kinase Gene Therapy-induced Programmed Cell Death as Studied by 1H NMR Spectroscopy in Vivo, ex Vivo, and in Vitro*

R. Kauppinen, J. Griffin, J. Nicholson, 2003, Journal of Biological Chemistry.

The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease

L. Mrzljak, C. Dominguez, D. Winkler, 2016, Experimental Neurology.

Vertigoheel promotes rodent cognitive performance in multiple memory tests

B. Seilheimer, C. V. von Arnim, Y. Burmeister, 2023, Frontiers in Neuroscience.

Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma.

R. Kauppinen, M. Garwood, S. Ylä-Herttuala, 2003, Cancer Research.

Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

Teemu Laitinen, Alejandra Sierra, Asla Pitkänen, 2011, Epilepsia.

The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain

N. Datson, A. González-Barriga, S. Mulders, 2017, PloS one.

The radical scavenger IAC (bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decantionate) decreases mortality, enhances cognitive functions in water maze and reduces amyloid plaque burden in hAβPP transgenic mice.

J. Yrjänheikki, G. Kalesnykas, E. Spisni, 2011, Journal of Alzheimer's disease : JAD.

Water diffusion in a rat glioma during ganciclovir‐thymidine kinase gene therapy‐induced programmed cell death in vivo: Correlation with cell density

R. Kauppinen, S. Ylä-Herttuala, O. Gröhn, 2004, Journal of magnetic resonance imaging : JMRI.

High‐resolution magic‐angle‐spinning 1H NMR spectroscopy reveals different responses in choline‐containing metabolites upon gene therapy‐induced programmed cell death in rat brain glioma

R. Kauppinen, J. Griffin, J. Nicholson, 2005, NMR in biomedicine.

Monitoring Gliomas In Vivo Using Diffusion-Weighted MRI During Gene Therapy-Induced Apoptosis

O. Gröhn, T. Liimatainen, K. Lehtimäki, 2011 .

J. Yrjänheikki, G. Kalesnykas, E. Spisni, 2011, Journal of Alzheimer's disease : JAD.