D. Focan-Henrard

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Phase I - II study to assess the feasibility and activity of the triple combination of 5-fluorouracil/folinic acid, carboplatin and irinotecan (CPT-11) administered by chronomodulated infusion for the treatment of advanced colorectal cancer. Final report of the BE-1603 study.

F. Kreutz, C. Focan, M. Graas, 2013, Pathologie-biologie.

Dose-response relationship of epirubicin-based first-line chemotherapy for advanced breast cancer: a prospective randomized trial.

C. Focan, C. Focan, F. Ries, 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Sequential administration of epirubicin and paclitaxel for advanced breast cancer. A phase I randomised trial.

J. Canon, G. Jerusalem, C. Focan, 2005, Anticancer research.

Cancer-associated alteration of circadian rhythms in carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) in humans.

F. Lévi, W. Hrushesky, C. Focan, 1986, Anticancer research.

Circadian CEA variability: when to sample.

V. Castronovo, F. Lévi, C. Focan, 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Implications of circadian clocks for the rhythmic delivery of cancer therapeutics.

Francis Lévi, F. Lévi, S. Giacchetti, 2007, Advanced drug delivery reviews.

Phase II trial with high-dose ifosfamide and mesna given in a 24-h infusion for advanced GI tract cancer

C. Focan, D. Focan-Henrard, J. Boossy, 2004, Cancer Chemotherapy and Pharmacology.

High-dose oral medroxyprogesterone acetate or tamoxifen as adjuvant hormone therapy for node-negative early-stage breast cancer: randomized trial with 7-year update.

J. Canon, C. Focan, M. Beauduin, 2004, Clinical breast cancer.

Induction of inflammation by immunological reactions

P. Franchimont, D. Focan-Henrard, 1976, Agents and Actions.

Chronotherapy with 5-fluorouracil, folinic acid and carboplatin for metastatic colorectal cancer; an interesting therapeutic index in a phase II trial.

F. Kreutz, C. Focan, D. Focan-Henrard, 2000, European journal of cancer.

Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion.

F. Kreutz, F. Lévi, H. Bismuth, 1999, Anti-cancer drugs.

[Evaluation of rest-activity rhythms in advanced non-small-cell lung cancer (NSCLC) patients. Importance of corticotherapy?].

C. Focan, J. Waterhouse, D. Focan-Henrard, 2003, Pathologie et biologie.

Importance of 5-fluorouracil dose-intensity in a double randomised trial on adjuvant portal and systemic chemotherapy for Dukes B2 and C colorectal cancer.

J. Canon, C. Focan, M. Beauduin, 2000, Anticancer Research.