K. Yamashita

发表

Pharmacokinetics of KRM-1648, a new benzoxazinorifamycin, in rats and dogs

K. Fujii, T. Ohashi, T. Mae, 1996, Antimicrobial agents and chemotherapy.

Chemotherapeutic efficacy of a newly synthesized benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex infection induced in mice

H. Tomioka, H. Saito, K. Sato, 1992, Antimicrobial Agents and Chemotherapy.

In vitro and in vivo activities of KRM-1648, a newly synthesized benzoxazinorifamycin, against Mycobacterium marinum.

H. Tomioka, H. Saito, K. Sato, 1992, Zentralblatt fur Bakteriologie : international journal of medical microbiology.

In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins

H. Tomioka, H. Saito, K. Sato, 1991, Antimicrobial Agents and Chemotherapy.

Pharmacological Properties of a New Anti-Inflammatory Compound, α-(3,5-Di-Tert-Butyl-4-Hydroxybenzylidene)-γ-Butyrolactone (KME-4), and Its Inhibitory Effects on Prostaglandin Synthetase and 5-Lipoxygenase

I. Katsumi, T. Yamashita, Kiyoshi Watanabe, 1984 .

Identification and antimicrobial activity of urinary metabolites of a rifamycin derivative in dog.

K. Fujii, T. Ohashi, T. Mae, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

In vitro metabolism of a rifamycin derivative by animal and human liver microsomes, whole blood and expressed human CYP3A isoform.

K. Fujii, T. Ohashi, T. Mae, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives.

K. Watanabe, F. Kuze, E. Konishi, 1993, Chemical & pharmaceutical bulletin.

Effects of a new adenosine deaminase inhibitor, isocoformycin, on toxicity, antitumor activity and tissue distribution of formycin A and 9-beta-D-arabinofuranosyladenine.

T. Takeuchi, H. Umezawa, M. Ohno, 1980, The Journal of antibiotics.

Tissues Blood Lung Liver Spleen Kidney Blood Lung Liver Spleen Kidney Blood Lung Liver Spleen Kidney Blood Lung Liver Spleen Kidney Concentration in ug

M. Ohno, T. Takeuchi, H. Umezawa, 2006 .

Bactericidal action at low doses of a new rifamycin derivative, 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl) benzoxazinorifamycin (KRM-1648) on Mycobacterium leprae inoculated into footpads of nude mice.

K. Hosoe, K. Yamashita, T. Yamane, 1992, Leprosy review.

High-performance liquid chromatographic determination of 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648) and its deacetyl metabolite in plasma, whole blood, urine and tissue samples in rats.

T. Ohashi, E. Konishi, K. Hosoe, 1994, Journal of chromatography. B, Biomedical applications.

Studies on styrene derivatives. II. Synthesis and antiinflammatory activity of 3,5-di-tert-butyl-4-hydroxystyrenes.

I. Katsumi, T. Yamashita, K. Hosoe, 1986, Chemical & pharmaceutical bulletin.

Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives.

I. Katsumi, T. Yamashita, K. Hosoe, 1986, Chemical & pharmaceutical bulletin.

Pharmacological properties of a new anti-inflammatory compound, alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolacto ne (KME-4), and its inhibitory effects on prostaglandin synthetase and 5-lipoxygenase.

I. Katsumi, T. Yamashita, K. Hosoe, 1984, Japanese journal of pharmacology.