Liang Shen

发表

Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent

Yusong Zhu, S. Franzblau, Shuhui Chen, 2022, Bioorganic & Medicinal Chemistry Letters.

Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping.

Yikai Wang, P. Sun, Weifeng Mao, 2017, Bioorganic & medicinal chemistry letters.

Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease.

Z. Gu, Hongjian Xu, Xiquan Zhang, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of a Series of Bile Acid Derivatives as FXR Agonists for Treatment of NASH.

X. Tian, Haiying He, Peng Li, 2017, ACS medicinal chemistry letters.

Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment.

Y. Hu, Jiong Lan, Haiying He, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor α/δ Agonist for the Treatment of Primary Biliary Cirrhosis.

Haiying He, Shuhui Chen, Deming Xu, 2019, ACS medicinal chemistry letters.

Synthesis and evaluation of hydrazinyl-containing pyrrolo[2,3-d]pyri midine series as potent, selective and oral JAK1 inhibitors for the treatment of rheumatoid arthritis.

Shuhui Chen, Wenyuan Qian, Weiwei Mao, 2022, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of anti-EV71 agents.

Z. Gu, Zhenzhong Wang, Peng Li, 2016, Bioorganic & medicinal chemistry letters.

Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR.

J. Li, Shuhui Chen, Jikui Sun, 2018, ACS medicinal chemistry letters.

Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment.

Z. Gu, Minghui Zhang, Haiying He, 2017, ACS medicinal chemistry letters.

Discovery of 3,3'-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection.

Z. Gu, Haiying He, Shuhui Chen, 2018, ACS medicinal chemistry letters.

Discovery and Evaluation of Pyrazolo[3,4-d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor.

Yuchuan Zhu, Weifeng Mao, Shuhui Chen, 2019, ACS medicinal chemistry letters.

Discovery and Assessment of Atropisomers of (±)-Lesinurad.

Z. Gu, Jianfei Wang, Yang Zhang, 2017, ACS medicinal chemistry letters.

Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073

Yuquan Wei, Cuicui Ma, Xiawei Wei, 2020, Antimicrobial Agents and Chemotherapy.

Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.

Z. Gu, Zhenzhong Wang, Haiying He, 2017, ACS medicinal chemistry letters.

The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo

P. Buchy, Shan Xu, R. Altmeyer, 2014, Emerging Microbes and Infections.

Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent.

Yusong Zhu, S. Franzblau, Ning Jiang, 2022, Bioorganic & medicinal chemistry letters.

Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD).

Wei Tang, Q. Gu, Yusong Zhu, 2022, Bioorganic & medicinal chemistry letters.

Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD).

Lihong Hu, Q. Gu, Yuanfeng Xia, 2020, Bioorganic & medicinal chemistry letters.

Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model.

Qi Li, D. Yao, Shuhui Chen, 2018, Bioorganic & Medicinal Chemistry Letters.

Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia.

L. Ye, Jingwei Tian, Yikai Wang, 2017, Bioorganic & medicinal chemistry letters.

The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia.

Jian Li, Liang Shen, Liang Ye, 2017, Bioorganic & medicinal chemistry letters.