Y. Yamaura

发表

Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions

K. Maeda, H. Kusuhara, Y. Sugiyama, 2022, Clinical pharmacology and therapeutics.

Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs

K. Maeda, H. Kusuhara, X. Chu, 2022, Clinical and translational science.

H. Yamazaki, Soonih Kim, K. Yano, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction

K. Harada, H. Yamada, H. Mizuguchi, 2019, Cellular and molecular gastroenterology and hepatology.

Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes.

K. Chiba, T. Kubota, H. Hara, 2000, British journal of clinical pharmacology.

Robust physiologically based pharmacokinetic model of rifampicin for predicting drug–drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidney

Y. Sugiyama, Kunal S. Taskar, R. Asaumi, 2022, CPT: pharmacometrics & systems pharmacology.

A new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model.

M. Fujita, T. Nabe, S. Nakade, 2017, Prostaglandins, leukotrienes, and essential fatty acids.

EFFECTS OF G 169 R AND P 34 S SUBSTITUTIONS PRODUCED BY MUTATIONS OF CYP 2 D 6 * 14 ON THE FUNCTIONAL PROPERTIES OF CYP 2 D 6 EXPRESSED IN V 79 CELLS

Kaoru Kobayashi, K. Chiba, M. Hosokawa, 2002 .

Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.

T. Nakao, M. Fujita, T. Nabe, 2015, Journal of medicinal chemistry.

Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography

H. Ohba, H. Tsukada, S. Katsumata, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Quantification of ONO-2952 occupancy of translocator protein 18 kDa in conscious monkey brain using positron emission tomography

H. Ohba, H. Tsukada, S. Katsumata, 2016 .

Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.

K. Shinozaki, T. Matsushita, A. Naganawa, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.

K. Shinozaki, T. Matsushita, A. Naganawa, 2015, Bioorganic & medicinal chemistry letters.

Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein.

Panayiotis D. Megaloikonomos, Hiroshi Watanabe, Rui Fujimura, 2022, Molecular pharmaceutics.

Predicting oxidation sites with order of occurrence among multiple sites for CYP4A-mediated reactions.

K. Yoshinari, Y. Yamazoe, Y. Yamaura, 2011, Drug metabolism and pharmacokinetics.

Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes.

K. Chiba, H. Fujii, H. Minami, 2001, British journal of clinical pharmacology.

Development, characterization and potential applications of a multicellular spheroidal human blood-brain barrier model integrating three conditionally immortalized cell lines.

H. Akita, T. Komori, Tomomi Furihata, 2021, Biological & pharmaceutical bulletin.

In Vitro-In Vivo Correlation of Blood–Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans

T. Komori, Tomomi Furihata, Hanae Morio, 2022, Pharmaceutical Research.

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.

M. Toda, H. Nakai, Y. Tobe, 2010, Bioorganic & medicinal chemistry.

Evaluation of Using Dogs to Predict Fraction of Oral Dose Absorbed in Humans for Poorly Water-Soluble Drugs.

S. Yamashita, K. Sugano, J. Katagi, 2018, Journal of pharmaceutical sciences.

A human immortalized cell-based blood-brain barrier tri-culture model: development and characterization as a promising tool for drug brain permeability studies.

N. Anzai, H. Akita, Shota Suzuki, 2019, Molecular pharmaceutics.

In ̄uence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes

K. Chiba, K. Kobayashi, H. Fujii, 2022 .

Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells.

Kaoru Kobayashi, K. Chiba, M. Hosokawa, 2002, Drug metabolism and disposition: the biological fate of chemicals.

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain.

M. Toda, H. Nakai, K. Yoshikawa, 2010, Bioorganic & medicinal chemistry.

Development , characterization and potential applications of a multicellular 3 spheroidal human blood-brain barrier model integrating three conditionally 4 immortalized cell lines 5 6

H. Akita, T. Komori, Tomomi Furihata, 2021 .

Development of a microphysiological model of human kidney proximal tubule function.

Danny D Shen, Catherine K Yeung, Kenneth E Thummel, 2016, Kidney international.

H. Yamazaki, Y. Uno, N. Murayama, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism

J. Himmelfarb, K. Thummel, Brian D. Chapron, 2016, Drug Metabolism and Disposition.

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.

M. Toda, H. Nakai, K. Yoshikawa, 2010, Bioorganic & medicinal chemistry.

Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats

H. Suna, S. Katsumata, N. Morimoto, 2015, Neuropharmacology.

Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.

M. Toda, H. Nakai, T. Nagase, 2009, Bioorganic & medicinal chemistry.

Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists.

M. Toda, T. Maruyama, T. Maruyama, 2011, Chemical & pharmaceutical bulletin.

Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha-1 Acid Glycoprotein.

T. Takeo, N. Nakagata, T. Maruyama, 2021, Molecular pharmaceutics.

H. Yamazaki, Soonih Kim, K. Yano, 2014, Xenobiotica; the fate of foreign compounds in biological systems.