K. Shimano

发表

Amiselimod, a novel sphingosine 1‐phosphate receptor‐1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk

K. Sugahara, H. Kataoka, H. Kumagai, 2016, British journal of pharmacology.

Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3

H. Matsuyuki, K. Sugahara, H. Kataoka, 2007, The Journal of Immunology.

Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models

K. Sugahara, T. Kakimoto, H. Utsumi, 2019, Journal of immunology research.

FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

M. Koyama, K. Sugahara, A. Fukunari, 2005, Cellular & molecular immunology.

Fingolimod (FTY720) ameliorates experimental autoimmune encephalomyelitis (EAE): I. Oral administration of FTY720 effectively inhibits re- lapse of EAE

M. Koyama, N. Seki, K. Sugahara, 2010 .

Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells

K. Sugahara, H. Utsumi, H. Kataoka, 2019, PloS one.

Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.

K. Adachi, K. Sugahara, Mahoko Asayama, 2010, Journal of medicinal chemistry.

Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: II. Effect of FTY720 and FTY720-phosphate on host-versus-graft and graft-versus-host reaction in mice.

K. Sugahara, H. Kataoka, N. Sato, 2005, Transplantation proceedings.

Existence of multiple receptors in single neurons: responses of single bullfrog olfactory neurons to many cAMP-dependent and independent odorants

K. Kurihara, M. Kashiwayanagi, K. Shimano, 1996, Brain Research.

Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis.

M. Koyama, N. Seki, K. Sugahara, 2011, International immunopharmacology.

Multiple sclerosis (PP-038)

D. Arnold, F. Najafi, A. Bar-Or, 2010 .

Fingolimod (FTY720) ameliorates experimental autoimmune encephalomyelitis (EAE)

M. Koyama, N. Seki, K. Sugahara, 2010 .