R. Kosa

发表

Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes

L. Di, J. Litchfield, Jian Lin, 2017, Drug Metabolism and Disposition.

DMD057000 1163..1173

R. Walsky, T. Goosen, Jennifer J. Harris, 2014 .

Relative Contributions of Cytochrome CYP 3 A 4 Versus CYP 3 A 5 for CYP 3 A-Cleared Drugs Assessed In Vitro Using a CYP 3 A 4-Selective Inactivator ( CYP 3 cide ) s

R. Obach, R. Walsky, T. Goosen, 2014 .

OATP1B1/1B3-mediated hepatic uptake determines the pharmacokinetics of large lipophilic acids: In vitro–in vivo evaluation in cynomolgus monkey

A. Kalgutkar, M. Varma, J. Litchfield, 2021 .

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats.

S. Wright, A. Kalgutkar, J. Pfefferkorn, 2010, Bioorganic & medicinal chemistry letters.

Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.

P. Loria, D. Hepworth, S. Bhattacharya, 2015, ACS Medicinal Chemistry Letters.

Simultaneous Assessment of Transporter-Mediated Drug–Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey

A. D. Rodrigues, Chester Costales, Sweta Modi, 2018, Drug Metabolism and Disposition.

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).

Ping Chen, Hong Shen, M. Pairish, 2020, Journal of medicinal chemistry.

Relative Contributions of Cytochrome CYP3A4 Versus CYP3A5 for CYP3A-Cleared Drugs Assessed In Vitro Using a CYP3A4-Selective Inactivator (CYP3cide)

R. Obach, R. Walsky, T. Goosen, 2014, Drug Metabolism and Disposition.

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Jing Chen, David B Duignan, Robert Aiello, 2012, Journal of medicinal chemistry.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

A. D. Rodrigues, G. S. Walker, L. Tremaine, 2017, Drug Metabolism and Disposition.

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.

P. Loria, D. Hepworth, S. Bhattacharya, 2014, ACS medicinal chemistry letters.

In Vitro–In Vivo Extrapolation of OATP1B-Mediated Drug–Drug Interactions in Cynomolgus Monkey

A. D. Rodrigues, A. Galetin, J. Houston, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

A. D. Rodrigues, A. David Rodrigues, Manthena V. S. Varma, 2018, Drug Metabolism and Disposition.

Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro-In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs.

L. Tremaine, M. Varma, Yi-An Bi, 2017, Journal of pharmaceutical sciences.