Takashi Kusama

Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data.

M. Shimizu, H. Yamazaki, H. Suemizu, 2019, The Journal of toxicological sciences.

Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice.

M. Shimizu, H. Yamazaki, H. Suemizu, 2018, The Journal of toxicological sciences.

R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys

M. Shimizu, H. Yamazaki, Tomonori Miura, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA.

M. Shimizu, H. Yamazaki, H. Suemizu, 2018, The Journal of toxicological sciences.

Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19

M. Shimizu, H. Yamazaki, E. Sasaki, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models

M. Shimizu, H. Yamazaki, E. Sasaki, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

In vivo and in vitro diclofenac 5‐hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants

M. Shimizu, H. Yamazaki, E. Sasaki, 2018, Biochemical pharmacology.

Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

M. Shimizu, H. Yamazaki, Tomonori Miura, 2017, Biopharmaceutics & drug disposition.

Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA.

M. Shimizu, H. Yamazaki, H. Suemizu, 2018, The Journal of toxicological sciences.