Don Costa

Neuropharmacokinetics of two investigational compounds in rats: divergent temporal profiles in the brain and cerebrospinal fluid.

Xing Chen, D. Flood, D. Welty, 2014, Biochemical pharmacology.

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.

D. Burnett, Raksha A. Acharya, H. Patzke, 2017, Journal of medicinal chemistry.

Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.

D. Burnett, Raksha A. Acharya, H. Patzke, 2021, Journal of medicinal chemistry.

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

D. Burnett, H. Patzke, Cuyue Tang, 2016, Alzheimer's Research & Therapy.

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

B. de Strooper, H. Zetterberg, L. Leventhal, 2012, Molecular Neurodegeneration.

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

B. de Strooper, H. Zetterberg, L. Leventhal, 2012, Molecular Neurodegeneration.

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

D. Burnett, H. Patzke, Cuyue Tang, 2016, Alzheimer's Research & Therapy.

GSM treatment after the onset of Aβ deposition in mice reduces total Aβ load

L. Leventhal, D. Flood, H. Patzke, 2012, Alzheimer's & Dementia.