A. DePaoli

发表

Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.

J. Chan, C. Mantzoros, J. Bullen, 2005, The Journal of clinical endocrinology and metabolism.

Relation of leptin pulse dynamics to fat distribution in HIV-infected patients.

S. Grinspoon, Michael L. Johnson, P. Koutkia, 2004, The American journal of clinical nutrition.

Glucagon-receptor-antagonism-mediated β-cell regeneration as an effective anti-diabetic therapy.

J. Zha, D. Lindhout, A. Kutach, 2022, Cell reports.

A Single‐Dose Placebo‐Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

Steven W. Martin, P. Bekker, Robyn Murphy, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes

J. Horowitz, S. Klein, B. Mittendorfer, 2011, Diabetes.

Short title: Leptin in Obesity and Metabolic Disorders

A. DePaoli, Gateway Boulevard, 2014 .

Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy.

P. Gorden, M. Skarulis, J. Reynolds, 2004, Metabolism: clinical and experimental.

Expression of Calcium Channel mRNAs in Rat Pancreatic Islets and Downregulation After Glucose Infusion

K. Polonsky, S. Seino, G. Bell, 1993, Diabetes.

Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight

M. Wong, J. Licinio, F. Whelan, 2007, Appetite.

Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.

T. Kusakabe, K. Nakao, K. Hosoda, 2007, The Journal of clinical endocrinology and metabolism.

The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients.

P. Gorden, C. Musso, E. Cochran, 2005, Metabolism: clinical and experimental.

G Protein-Activated Inwardly Rectifying Potassium Channel (GIRK1/KGA) mRNA in Adult Rat Heart and Brain by in Situ Hybridization Histochemistry

M. Stoffel, G. Bell, A. DePaoli, 1994, Molecular and Cellular Neuroscience.

Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain: Analysis by RNA blotting and in situ hybridization histochemistry

T. Reisine, K. Yasuda, C. Breder, 1994, Neuroscience.

Recombinant human leptin in women with hypothalamic amenorrhea.

J. Chan, C. Mantzoros, C. Welt, 2004, The New England journal of medicine.

Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis.

J. Trotter, J. Frias, C. Guy, 2020, Gastroenterology.

Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial.

P. Thuluvath, M. Kipnes, M. Abdelmalek, 2022, The lancet. Gastroenterology & hepatology.

NGM282, a novel variant of FGF19, significantly reduces hepatic steatosis and key biomarkers of NASH: results of a Phase 2, multicenter, randomized, double-blinded, placebo controlled trial in biopsy-confirmed NASH patients

J. Trotter, R. Loomba, M. Abdelmalek, 2017 .

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19.

T. Arora, Hong Yang, D. Lindhout, 2014, Cancer research.

Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells.

C. Ross, A. Sharp, G. Bell, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Effects of leptin replacement on macro- and micronutrient preferences

R. Elashoff, M. Wong, J. Licinio, 2007, International Journal of Obesity.

Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy.

S. Holland, G. Uzel, P. Gorden, 2006, The Journal of clinical endocrinology and metabolism.

Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?

C. Mantzoros, R. Henry, F. Dunn, 2014, Diabetes Care.

Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5.

C. Burant, G. Bell, N. Davidson, 1993, The American journal of physiology.

NGM 282 for treatment of non-alcoholic steatohepatitis : a multicentre , randomised , double-blind , placebo-controlled , phase 2 trial

J. Trotter, M. Jaros, R. Loomba, 2018 .

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

J. Trotter, M. Jaros, R. Loomba, 2018, The Lancet.

Veillonella as a bile acid-sensitive bacteria and a microbiome-based biomarker for aldafermin (NGM282) in patients with non-alcoholic steatohepatitis

A. Sanyal, R. Loomba, Duy M. Dinh, 2020, Journal of Hepatology.

Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases

A. Sanyal, G. Hirschfield, U. Beuers, 2021, JHEP reports : innovation in hepatology.

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2‐deficient mice

R. M. Learned, H. Tian, L. Ling, 2015, Hepatology.

Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.

C. Mantzoros, G. Matarese, H. Moon, 2011, European journal of endocrinology.

140-LB: NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects

J. Olefsky, L. Morrow, M. Bashir, 2019, Diabetes.

Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial.

M. Karsdal, J. Trotter, J. Drenth, 2019, Journal of hepatology.

Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus.

E. Chang, M. Musch, M. Rao, 1996, The American journal of physiology.

Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy.

S. O’Rahilly, M. Turman, P. Gorden, 2004, The Journal of clinical endocrinology and metabolism.

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15.

Hong Yang, R. M. Learned, H. Tian, 2017, Journal of hepatology.

NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial

B. Leggett, M. Weltman, E. Carey, 2018, Hepatology communications.

University of Birmingham Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis:

Harrison, M. Karsdal, J. Trotter, 2018 .

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.

R. Bataller, D. Fouts, E. Verna, 2018, Journal of hepatology.

Lymphoma in acquired generalized lipodystrophy

E. Jaffe, J. Chan, C. Vigouroux, 2016, Leukemia & lymphoma.

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.

M. Stoffel, J. Sturis, K. Polonsky, 1995, Diabetes.

A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.

E. Chang, M. Musch, M. Rao, 1994, The Journal of biological chemistry.

Na+/H+ exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization.

E. Chang, M. Musch, M. Rao, 1994, The Journal of clinical investigation.

Blood pressure and vascular effects of leptin in humans.

R. Brook, R. Bard, S. Rajagopalan, 2007, Metabolic syndrome and related disorders.

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.

K. Petersen, S. Dufour, D. Befroy, 2002, The Journal of clinical investigation.

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

M. Stoffel, J. Sturis, K. Polonsky, 1995, Diabetes.

Expression of a thyroid hormone-responsive recombinant gene introduced into adult mice livers by replication-defective adenovirus can be regulated by endogenous thyroid hormone receptor.

C. Burant, Y. Hayashi, S. Refetoff, 1994, The Journal of biological chemistry.

NGM282 improves fibrosis and NASH-related histology in 12 weeks in patients with biopsy-confirmed NASH, which is preceded by significant decreases in hepatic steatosis, liver transaminases and fibrosis markers at 6 weeks

R. Banerjee, M. Jaros, C. Guy, 2018 .

Glucocorticoids regulate Na+/H+ exchange expression and activity in region- and tissue-specific manner.

C. Burant, E. Chang, M. Musch, 1994, The American journal of physiology.

Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apolipoprotein B mRNA editing enzyme: functional role in the modulation of apoB mRNA editing.

N. Davidson, F. Giannoni, S. Skarosi, 1995, Journal of lipid research.

Selective peroxisome proliferator-activated receptor gamma (PPARgamma) modulation as a strategy for safer therapeutic PPARgamma activation.

L. Higgins, A. DePaoli, 2010, The American journal of clinical nutrition.

Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy.

P. Gorden, E. Oral, N. Sebring, 2002, The Journal of clinical endocrinology and metabolism.

Clinical Applications of Leptin

Elif A. Oral, A. DePaoli, 2006 .

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Graham M Lord, S. O’Rahilly, R. Lechler, 2002, The Journal of clinical investigation.

20 years of leptin: leptin in common obesity and associated disorders of metabolism.

A. Depaoli, A. DePaoli, 2014, The Journal of endocrinology.

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy.

S. O’Rahilly, I. Farooqi, A. Depaoli, 2004, The Journal of clinical endocrinology and metabolism.

Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates.

C. Mantzoros, Jennifer Lee, A. DePaoli, 2004, The Journal of clinical endocrinology and metabolism.

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.

R. Krauss, M. Wong, J. Licinio, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.

J. Chan, C. Mantzoros, J. Veldhuis, 2003, The Journal of clinical investigation.

Leptin-replacement therapy for lipodystrophy.

M. Reitman, Simeon I. Taylor, A. Garg, 2002, The New England journal of medicine.

Efficacy of recombinant methionyl human leptin therapy for the extreme insulin resistance of the Rabson-Mendenhall syndrome.

P. Gorden, E. Cochran, E. Oral, 2004, The Journal of clinical endocrinology and metabolism.

Characterization of leptin pulse dynamics and relationship to fat mass, growth hormone, cortisol, and insulin.

S. Grinspoon, Michael L. Johnson, P. Koutkia, 2003, American journal of physiology. Endocrinology and metabolism.

Efficacy of Metreleptin for Weight Loss in Overweight and Obese Adults with Low Leptin Levels

S. O’Rahilly, M. Stewart, A. Long, 2018, Diabetes.

Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy

D. Kleiner, M. Ghany, P. Gorden, 2005, Hepatology.

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

D. Brenner, D. Fouts, M. Downes, 2018, Hepatology.

Effect of leptin replacement on brain structure in genetically leptin-deficient adults.

John A Matochik, Edythe D London, Julio Licinio, 2005, The Journal of clinical endocrinology and metabolism.

Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes.

M. Hediger, C. Burant, J. Buse, 1994, The Journal of clinical investigation.

A multi-institutional phase ii study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancer.

S. Taneja, E. Small, G. Bubley, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Graft-versus-host disease and liver transplantation.

J. Bitran, A. DePaoli, 1992, Annals of internal medicine.

A Single‐Dose Placebo‐Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

Colin R Dunstan, Steven W. Martin, P. Bekker, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.

M. Schambelan, C. Grunfeld, J. Schwarz, 2009, The Journal of clinical endocrinology and metabolism.

The Commensal Microbe V eillonella as a Marker for Response to an FGF19 Analog in NASH

A. Sanyal, R. Loomba, S. Harrison, 2020, Hepatology.

A nontumorigenic variant of FGF19 treats cholestatic liver diseases

D. Lindhout, R. M. Learned, H. Tian, 2014, Science Translational Medicine.

Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis

R. M. Learned, H. Tian, L. Ling, 2019, Journal of Lipid Research.

NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis

J. Trotter, R. Banerjee, M. Jaros, 2019, Hepatology.

FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis

S. Hunt, T. Adams, R. M. Learned, 2019, Diabetes.