Tyler Chickering

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

S. Milstein, M. Manoharan, S. Chong, 2022, Nature Biotechnology.

RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

J. McIninch, Elena K. Stamenova, Svetlana Shulga-Morskaya, 2022, bioRxiv.

RNAs Containing Carbocyclic Ribonucleotides.

M. Manoharan, M. Egli, J. Harp, 2021, Organic letters.

Expanding the Reach of RNAi Therapeutics with Next Generation Lipophilic siRNA Conjugates

S. Milstein, M. Manoharan, S. Chong, 2021 .

Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine

M. Manoharan, M. Egli, A. Kel'in, 2020, Nucleic acids research.

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

K. Bissig, June Qin, M. Ljungberg, 2023, bioRxiv.