Takashi Yamamoto

发表

Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke.

A. Takahara, Takashi Yamamoto, 2009, Current topics in medicinal chemistry.

The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.

A. Takahara, Tomoko Takeda, S. Fujita, 2008, Bioorganic & medicinal chemistry letters.

Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity.

A. Takahara, Tomoko Takeda, Hiroshi Yamamoto, 2006, Bioorganic & medicinal chemistry.

Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.

H. Uneyama, A. Takahara, Tomoko Takeda, 2006, Bioorganic & medicinal chemistry letters.

The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.

V. Hruby, H. Yamamura, T. Vanderah, 2009, Bioorganic & medicinal chemistry.

Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives.

A. Takahara, Tomoko Takeda, S. Fujita, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.

K. Ohsumi, K. Fujita, S. Iwayama, 2007, Bioorganic & medicinal chemistry letters.

Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.

A. Takahara, Tomoko Takeda, S. Fujita, 2011, Bioorganic & medicinal chemistry letters.

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2009, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

V. Hruby, E. Navratilova, H. Yamamura, 2007 .

A Structure–Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are δ / μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

V. Hruby, E. Navratilova, T. Vanderah, 2009 .

The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2008, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2007, Journal of medicinal chemistry.

Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation.

V. Hruby, T. Vanderah, A. Keresztes, 2012, European journal of pharmacology.

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.

T. Natsume, S. Iemura, Makoto Shiozaki, 2014, Bioorganic & medicinal chemistry.

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

V. Hruby, H. Yamamura, T. Vanderah, 2011, Journal of medicinal chemistry.

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.

V. Hruby, E. Navratilova, H. Yamamura, 2010, Journal of medicinal chemistry.

Novel bifunctional peptides as opioid agonists and NK-1 antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2009, Advances in experimental medicine and biology.

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential

V. Hruby, R. Khanna, T. Vanderah, 2017, Molecular Psychiatry.

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.

V. Hruby, E. Navratilova, T. Vanderah, 2013, Bioorganic & medicinal chemistry letters.

A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

V. Hruby, E. Navratilova, H. Yamamura, 2008, Journal of medicinal chemistry.

Tu1864 A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (Pikfyve) Inhibitor Ameliorates Mouse Colitis by Inhibition of IL-12 and IL-23 Production From Macrophages

Makoto Shiozaki, R. Nakagawa, S. Takeshita, 2012 .

Inhibition of Opioid Induced Reward via Genetic and Pharmacological Manipulations

V. Hruby, T. Vanderah, T. Largent-Milnes, 2017, The FASEB Journal.

Building a Better Analgesic: Multifunctional Compounds that Address Injury-Induced Pathology to Enhance Analgesic Efficacy while Eliminating Unwanted Side Effects

T. Vanderah, E. Bilsky, T. Largent-Milnes, 2013, The Journal of Pharmacology and Experimental Therapeutics.