Andrew D. Huber

发表

New placement prediction and mitigation techniques for local routing congestion

Taraneh Taghavi, Shyam Ramji, Gi-Joon Nam, 2010, 2010 IEEE/ACM International Conference on Computer-Aided Design (ICCAD).

I/O impedance matching algorithm for high-performance ASICs

Paul S. Zuchowski, Douglas W. Stout, Andrew D. Huber, 1997, Proceedings. Tenth Annual IEEE International ASIC Conference and Exhibit (Cat. No.97TH8334).

GLARE: Global and local wiring aware routability evaluation

Sachin S. Sapatnekar, Natarajan Viswanathan, Charles J. Alpert, 2012, DAC Design Automation Conference 2012.

Design planning for high-performance ASICs

Rajesh Gupta, David Y. Yang, S. Wayne Bollinger, 1996, IBM J. Res. Dev..

Techniques for scalable and effective routability evaluation

Sachin S. Sapatnekar, Natarajan Viswanathan, Charles J. Alpert, 2014, TODE.

Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores.

Andrew D. Huber, Emily M. Coonrod, S. Sarafianos, 2018, ACS infectious diseases.

Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2017, European journal of medicinal chemistry.

Multiplex single-cell visualization of nucleic acids and protein during HIV infection

Andrew D. Huber, A. Engelman, S. Sarafianos, 2017, Nature Communications.

SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.

Andrew D. Huber, Shondra M. Pruett-Miller, Taosheng Chen, 2022, ACS medicinal chemistry letters.

Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.

Andrew D. Huber, Taosheng Chen, J. Seetharaman, 2021, Journal of the American Chemical Society.

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Andrew D. Huber, Taosheng Chen, Shyaron Poudel, 2022, Drug Metabolism and Disposition.

Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication

Andrew D. Huber, S. Sarafianos, M. Hannink, 2019, Viruses.

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.

Andrew D. Huber, S. Sarafianos, K. Kirby, 2017, European journal of medicinal chemistry.

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2017, Journal of medicinal chemistry.

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.

Andrew D. Huber, Taosheng Chen, A. Munro, 2020, Journal of medicinal chemistry.

Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus

Andrew D. Huber, C. Rice, S. Sarafianos, 2019, Viruses.

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2019, European journal of medicinal chemistry.

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2018, European journal of medicinal chemistry.

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2018, European journal of medicinal chemistry.

A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase

Andrew D. Huber, Skyler T. Kramer, S. Sarafianos, 2017, Antimicrobial Agents and Chemotherapy.

3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

Andrew D. Huber, S. Sarafianos, H. Mitsuya, 2017, Antimicrobial Agents and Chemotherapy.

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.

Andrew D. Huber, S. Sarafianos, Jing Tang, 2017, European journal of medicinal chemistry.

3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2016, Journal of medicinal chemistry.

SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase Inhibitors

Andrew D. Huber, S. Sarafianos, N. Landau, 2014, Antimicrobial Agents and Chemotherapy.

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

Andrew D. Huber, S. Sarafianos, H. Mitsuya, 2013, Retrovirology.

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms*

Andrew D. Huber, S. Sarafianos, H. Mitsuya, 2014, The Journal of Biological Chemistry.

The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells

Andrew D. Huber, Emily M. Coonrod, S. Sarafianos, 2018, mSphere.

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

Andrew D. Huber, Taosheng Chen, D. Pintel, 2020, Cellular and Molecular Life Sciences.

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Andrew D. Huber, Taosheng Chen, J. Seetharaman, 2022, Nucleic acids research.

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2019, European journal of medicinal chemistry.

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

Andrew D. Huber, Taosheng Chen, D. Pintel, 2020, Cellular and Molecular Life Sciences.

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

Andrew D. Huber, S. Sarafianos, R. Ralston, 2023, Viruses.

CITCO Directly Binds to and Activates Human Pregnane X Receptor

Andrew D. Huber, Taosheng Chen, S. Chai, 2019, Molecular Pharmacology.

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

Andrew D. Huber, S. Sarafianos, H. Mitsuya, 2013, Retrovirology.

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Andrew D. Huber, Taosheng Chen, Jing Wu, 2023, Acta Pharmaceutica Sinica B.

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Andrew D. Huber, Taosheng Chen, J. Seetharaman, 2023, Proceedings of the National Academy of Sciences of the United States of America.