Jules C Hancox

发表

Measuring kinetics and potency of hERG block for CiPA.

Monique J Windley, Najah Abi-Gerges, Bernard Fermini, 2017, Journal of pharmacological and toxicological methods.

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study

Henggui Zhang, Wei Wang, Shanzhuo Zhang, 2018, PLoS Comput. Biol..

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes.

Jules C Hancox, Harry J Witchel, James T Milnes, 2002, Journal of pharmacological and toxicological methods.

Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study.

Henggui Zhang, Sanjay Kharche, Jules C Hancox, 2008, Progress in biophysics and molecular biology.

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone.

Jules C Hancox, Yi H. Zhang, J. Hancox, 2010, Journal of electrocardiology.

Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation.

Jules C Hancox, Harry J Witchel, James T Milnes, 2004, Biochemical and biophysical research communications.

Inhibitory actions of the selective serotonin re‐uptake inhibitor citalopram on HERG and ventricular L‐type calcium currents

Jules C Hancox, Harry J Witchel, J. Hancox, 2002, FEBS letters.

The hERG potassium channel and hERG screening for drug-induced torsades de pointes.

Jules C Hancox, Yi H. Zhang, J. Hancox, 2008, Pharmacology & therapeutics.

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Henggui Zhang, Ismail Adeniran, Jules C Hancox, 2017, Scientific Reports.

Integration of Genetics into a Systems Model of Electrocardiographic Traits Using HumanCVD BeadChip

Henggui Zhang, Tom R. Gaunt, Fotios Drenos, 2012, Circulation. Cardiovascular genetics.

Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells.

Henggui Zhang, Jules C Hancox, Mark R Boyett, 2010, Biophysical journal.

The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping

Jules C Hancox, Richard B Sessions, Harry J Witchel, 2004, Molecular Pharmacology.

Computer Three-Dimensional Reconstruction of the Atrioventricular Node

Henggui Zhang, Mitsuru Yamamoto, Shin Inada, 2008, Circulation research.

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2010, Journal of pharmacological and toxicological methods.

The short QT syndrome

Jules C Hancox, Harry J Witchel, J. Hancox, 2011, Journal of Interventional Cardiac Electrophysiology.

Mode‐dependent inhibition by quinidine of Na+–Ca2+ exchanger current from guinea‐pig isolated ventricular myocytes

Jules C Hancox, Y H Zhang, 2002, Clinical and experimental pharmacology & physiology.

High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.

Jules C Hancox, Harry J Witchel, James T Milnes, 2004, Biochemical and biophysical research communications.

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.

Jules C Hancox, Stefan Knapp, Jennifer Batson, 2017, ACS chemical biology.

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2006, British journal of pharmacology.

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study.

Henggui Zhang, Kuanquan Wang, Yongfeng Yuan, 2017, Chaos.

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.

Jules C Hancox, Harry J Witchel, J. Hancox, 2006, Journal of molecular and cellular cardiology.

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study.

Henggui Zhang, Shin Inada, Sanjay Kharche, 2008, Progress in biophysics and molecular biology.

The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C.

Jules C Hancox, Harry J Witchel, James T Milnes, 2005, Biochemical and biophysical research communications.

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Jules C Hancox, J. Hancox, Hongwei Cheng, 2015, Physiological reports.

Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria

Henggui Zhang, Sanjay Kharche, Jules C Hancox, 2013, The Journal of physiology.

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias.

Jules C Hancox, J. Hancox, Michael E O'Leary, 2010, British journal of clinical pharmacology.

Atrial Remodeling and the Substrate for Atrial Fibrillation in Rat Hearts With Elevated Afterload

Jules C Hancox, Shang-Jin Kim, J. Hancox, 2011, Circulation. Arrhythmia and electrophysiology.

A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells.

Jules C Hancox, D. Bates, J. Hancox, 2006, Cell calcium.