Xu Shen

发表

IdentificationofNovelFalcipain-2InhibitorsasPotentialAntimalarialAgentsthroughStructure-Based Virtual Screening

Lili Chen, Jian Li, Hualiang Jiang, 2009 .

Study on Value Evaluation Model of Used Excavators Based on AHP Method

Xu Shen, 2018, 2018 International Conference on Information Systems and Computer Aided Education (ICISCAE).

Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).

Xu Shen, Ren Wen, Jianhua Shen, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?

Weiliang Zhu, Jian Li, Honglin Li, 2011, Journal of medicinal chemistry.

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Li Zhang, Yu Qin, Jingkang Shen, 2006, Bioorganic & Medicinal Chemistry.

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Ying Yu, Zhenting Gao, Wenzhong Yan, 2012, Journal of medicinal chemistry.

Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant

Cheng Luo, Mingyue Zheng, Zhongjie Liang, 2011, PloS one.

Identification of probable genomic packaging signal sequence from SARS-CoV genome by bioinformatics analysis.

Cheng Luo, Guo-Ping Zhao, Zong-Ming Guo, 2003, Acta pharmacologica Sinica.

Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique

Fei Ye, Jing Chen, Xu Shen, 2005, Acta Pharmacologica Sinica.

Inhibitor discovery targeting the intermediate structure of beta-amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of beta-amyloid peptide.

Jianpeng Ma, Xu Shen, Kaixian Chen, 2006, Biochemistry.

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization

Li Du, Jing Chen, Xu Shen, 2005, Journal of Biological Chemistry.

The conserved residue Phe273(282) of PPARα(γ), beyond the ligand-binding site, functions in binding affinity through solvation effect

Fei Ye, Xu Shen, Hualiang Jiang, 2005 .

Crystal Structure of HAb18G/CD147

Ning Wen, Jian Zhang, Xu Shen, 2008, Journal of Biological Chemistry.

Inhibitory mode of indole-2-carboxamide derivatives against HLGPa: molecular docking and 3D-QSAR analyses.

Hong Liu, Xu Shen, Hualiang Jiang, 2004, Bioorganic & medicinal chemistry.

Structural Insights into Cellulolytic and Chitinolytic Enzymes Revealing Crucial Residues of Insect β-N-acetyl-D-hexosaminidase

Qing Yang, Wei Chen, Xu Shen, 2012, PloS one.

Putative hAPN receptor binding sites in SARS_CoV spike protein.

Cheng Luo, Guo-Ping Zhao, Zong-Ming Guo, 2003, Acta pharmacologica Sinica.

(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice

Jing Chen, Jiming Ye, Mingyue Zheng, 2012, PloS one.

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.

Jianhua He, Orly Dym, Joel L Sussman, 2012, Acta crystallographica. Section D, Biological crystallography.

Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/H1N1)?

Cheng Luo, Jianpeng Ma, Weiliang Zhu, 2009, Cell Research.

Techniques used for the discovery of therapeutic compounds: The case of SARS

Xu Shen, Hualiang Jiang, Kaixian Chen, 2006, Drug Discovery Today: Technologies.

Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.

Luhua Lai, Jianfeng Pei, Jin Huang, 2009, Journal of medicinal chemistry.

Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.

Honglin Li, Kunqian Yu, Mingyue Zheng, 2009, Journal of medicinal chemistry.

Natural products as a gold mine for selective matrix metalloproteinases inhibitors.

Honglin Li, Jin Huang, Weidong Zhang, 2012, Bioorganic & medicinal chemistry.

Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections.

Zhiqiang Qin, Antoine Danchin, Yang Wu, 2006, BMC microbiology.

Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro

Christian Drosten, Burkhard Ludewig, Elke Scandella, 2005, Journal of Virology.

Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with β-secretase

Zhili Zuo, Weiliang Zhu, Xu Shen, 2005 .

Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor β agonist and induces GLUT4 expression in CHO-K1 cells

Jin Huang, Xu Shen, Hong Shen, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode.

Li Li, Xu Shen, Hualiang Jiang, 2011, Journal of molecular biology.

Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis.

Xu Shen, Kai-Xian Chen, Jianhua Shen, 2004, Acta pharmacologica Sinica.

Discovering Severe Acute Respiratory Syndrome Coronavirus 3CL Protease Inhibitors: Virtual Screening, Surface Plasmon Resonance, and Fluorescence Resonance Energy Transfer Assays

Xu Shen, Jianhua Shen, Shuai Chen, 2006, SLAS Discovery.

Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives

Jian Li, Hong Liu, Bing Xiong, 2006, Acta Pharmacologica Sinica.

Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization

Xu Shen, Cong Han, Li-hong Hu, 2008, Acta Pharmacologica Sinica.

Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation.

Li Du, Xu Shen, Kaixian Chen, 2006, Journal of biochemistry.

Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

Cheng Luo, Weiliang Zhu, Jian Li, 2006, Bioorganic & Medicinal Chemistry.

Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor*

Peng Liu, Xin Xu, Xing Xu, 2015, The Journal of Biological Chemistry.

A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening.

Cheng Luo, Jing Chen, Xu Shen, 2003, Acta pharmacologica Sinica.

Small envelope protein E of SARS: cloning, expression, purification, CD determination, and bioinformatics analysis.

Jing Chen, Xu Shen, Hai-Bin Luo, 2003, Acta pharmacologica Sinica.

Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease.

Jing Chen, Xu Shen, Ruoming Wu, 2014, Bioorganic & medicinal chemistry.

In vitro biochemical and thermodynamic characterization of nucleocapsid protein of SARS

Fei Ye, Jing Chen, Xu Shen, 2004, Biophysical Chemistry.

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.

Honglin Li, Jin Huang, Yufang Xu, 2012, Journal of medicinal chemistry.

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A

Cheng Luo, Jingkang Shen, Suxin Zheng, 2004, Biochemical and Biophysical Research Communications - BBRC.

Protein tyrosine phosphatase 1B regulates TGF beta 1-induced Smad2 activation through PI3 kinase-dependent pathway.

Fei Ye, Xu Shen, Hualiang Jiang, 2006, Cytokine.

Protein tyrosine phosphatase 1B regulates TGF beta 1-induced Smad2 activation through PI3 kinase-dependent pathway.

Fei Ye, Xu Shen, Hualiang Jiang, 2006, Cytokine.

Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases.

Qing Yang, Xu Shen, Fengyi Liu, 2011, Biochemical Journal.

The Dipeptide H‐Trp‐Glu‐OH Shows Highly Antagonistic Activity against PPARγ: Bioassay with Molecular Modeling Simulation

Fei Ye, Xu Shen, Hai-Bin Luo, 2006, Chembiochem : a European journal of chemical biology.

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Honglin Li, Jin Huang, Jin Zhu, 2009, Journal of medicinal chemistry.

Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling.

Jian Zhang, Xu Shen, Cong Han, 2007, Bioorganic & medicinal chemistry.

Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum*

Xu Shen, Rolf Hilgenfeld, Hualiang Jiang, 2006, Journal of Biological Chemistry.