D. Lenz

发表

Development of a Rat Model for Subacute Exposure to the Toxic Organophosphate VX

D. M. Maxwell, D. Lenz, L. Austin, 1996 .

Human butyrylcholinesterase efficacy against nerve agent exposure

C. Sabourin, D. Lenz, B. Reed, 2017, Journal of biochemical and molecular toxicology.

Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents

H. Soreq, T. Mor, I. Cherni, 2010, Proceedings of the National Academy of Sciences.

Organophosphorus Exposure Chapter 7 NERVE AGENT BIOSCAVENGER : DEVELOPMENT OF A NEW APPROACH TO PROTECT AGAINST ORGANOPHOSPHORUS EXPOSURE

B. P. Doctor, D. Cerasoli, A. Saxena, 2009 .

Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates.

C. A. Castro, C. Broomfield, R. P. Solana, 1991, The Journal of pharmacology and experimental therapeutics.

Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents

David T. Yeung, D. Cerasoli, D. Lenz, 2008 .

8 Nerve Agent Bioscavengers: Progress in Development of a New Mode of Protection against Organophosphorus Exposure

B. Lukey, P. Masson, H. Salem, 2007 .

Nerve Agent Bioscavengers: Protection against High- and Low- Dose Organophosphorus Exposure*

C. Broomfield, D. Cerasoli, D. M. Maxwell, 2000 .

On the nature of the serum enzyme catalyzing paraoxon hydrolysis.

J. S. Holton, D. Lenz, L. E. Deguehery, 1973, Biochimica et biophysica acta.

Hepatic subcellular localization of cresylbenzodioxaphosphorin oxide (CBDP)-sensitive soman binding sites.

D. M. Maxwell, D. Lenz, K. Brecht, 1990, Biochemical pharmacology.

Antibody quantitation using an immunoadsorbent and the unlabeled antibody enzyme method.

D. Lenz, 1976, Journal of immunological methods.

Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP).

C. Broomfield, L. Boucher, B. Maciver, 1989, Biochemical pharmacology.

Studies Using a Monoclonal Antibody against Soman

H. Benschop, K. Hunter, A. Brimfield, 1984 .

Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

S. Langermann, Annie Bellemare, A. Lazaris, 2008, BMC biotechnology.

Synthesis of Unsymmetrically Substituted α-Aminoalkylphosphonate Esters

R. Moriarty, A. Brimfield, D. Lenz, 1995 .

Transport of cyanide into guinea pig cardiac mitochondria.

D. Lenz, L. S. Pellicore, J. Wisler, 1991, Toxicology letters.

The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats.

D. M. Maxwell, D. E. Lenz, W. Groff, 1987, Toxicology and applied pharmacology.

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.

P. Masson, O. Lockridge, L. Schopfer, 2008, Chemico-biological interactions.

Effects of repeated injection of sublethal doses of soman on behavior and on brain acetylcholine and choline concentrations in the rat

T. Shih, D. M. Maxwell, D. Lenz, 1990, Psychopharmacology.

A pharmacodynamic model for soman in the rat.

C. P. Vlahacos, D M Maxwell, C P Vlahacos, 1988, Toxicology letters.

Bioscavenger for protection from toxicity of organosphosphorus compounds

B. P. Doctor, Wei Sun, T. Myers, 2007, Journal of Molecular Neuroscience.

Nerve Agent Bioscavengers: Protection With Reduced Behavioral Effects

D. Cerasoli, D. Lenz, 2002 .

Quantification of the organophosphorus nerve agent soman by competitive inhibition enzyme immunoassay using monoclonal antibody

A. Brimfield, D. Lenz, K. Hunter, 1982, FEBS letters.

Hydrogen-deuterium exchange of trypsin and trypsin derivatives.

W. P. Bryan, D. Lenz, 1969, Biochemistry.

Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs

D. Cerasoli, H. Mumford, D. Lenz, 2011, Clinical toxicology.

Kinetic properties of soluble and membrane-bound acetylcholinesterase from electric eel.

D. M. Maxwell, D. Lenz, M. Walden, 1984, Life sciences.

Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning

S. Langermann, Annie Bellemare, M. Leduc, 2007, Proceedings of the National Academy of Sciences.

Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.

Tamara C. Otto, C. Cadieux, D. Cerasoli, 2019, Biochemical pharmacology.

Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.

P. Aisen, R. K. Gordon, B. P. Doctor, 2005, Chemico-biological interactions.

Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys.

B. P. Doctor, D. Cerasoli, A. Saxena, 2005, Chemico-biological interactions.

Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review.

L. Lumley, David T. Yeung, D. Cerasoli, 2007, Toxicology.

Organophosphate skin decontamination using immobilized enzymes.

R. K. Gordon, B. P. Doctor, A. Russell, 1999, Chemico-biological interactions.

Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys.

B. P. Doctor, Wei Sun, A. Saxena, 2008, Chemico-biological interactions.

Role of immunogen design in induction of soman-specific monoclonal antibodies.

D. Cerasoli, D. Lenz, J. Johnson, 2005, Immunology letters.

Catalytic antibodies hydrolysing organophosphorus esters.

A. Brimfield, C. Broomfield, D. M. Maxwell, 1993, Chemico-biological interactions.

Monoclonal antibodies against soman: characterization of soman stereoisomers.

J. Scott, J. Yourick, D. Lenz, 1992, Immunology letters.

Studies using a monoclonal antibody against soman.

H. Benschop, C. van Dijk, K. Hunter, 1984, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Butyrylcholinesterase as a therapeutic drug for protection against percutaneous VX.

E. Clarkson, S. Schulz, D. Cerasoli, 2010, Chemico-biological interactions.

Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig.

H. Ehrlich, H. Schwarz, W. Teschner, 2010, Chemico-biological interactions.

Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae.

David C. Davis, E. Kovaleva, G. Buchman, 2010, Chemico-biological interactions.

Putative role of proteolysis and inﬂammatory response in the toxicity of nerve and blister chemical warfare agents: implications for multi‐threat medical countermeasures

William J Smith, F. Cowan, C. Broomfield, 2003, Journal of applied toxicology : JAT.

A gas chromatographic-mass spectrometric approach to examining stereoselective interaction of human plasma proteins with soman.

David T. Yeung, D. Cerasoli, J. R. Smith, 2008, Journal of analytical toxicology.

Chimeric Recombinant Mammalian Paraoxonase-1 Enzymes

T. Magliery, Tamara C. Otto, David T. Yeung, 2010 .

Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes.

T. Magliery, Tamara C. Otto, David T. Yeung, 2009, Biochemistry.

Direct detection of stereospecific soman hydrolysis by wild‐type human serum paraoxonase

David T. Yeung, D. Cerasoli, J. R. Smith, 2007, The FEBS journal.

Solubilization and Humanization of Paraoxonase-1

T. Magliery, Tamara C. Otto, D. Cerasoli, 2012, Journal of lipids.

Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights.

Carrigan J. Hayes, Peng Tao, Tamara C. Otto, 2010, Journal of physical organic chemistry.

In silico analyses of substrate interactions with human serum paraoxonase 1

Anders Wallqvist, A. Wallqvist, Xin Hu, 2009, Proteins.

In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger.

N. Greig, B. P. Doctor, C. Karatzas, 2005, Chemico-biological interactions.

Analysis of active‐site amino‐acid residues of human serum paraoxonase using competitive substrates

David T. Yeung, D. Lenz, Douglas M. Cerasoli, 2005, The FEBS journal.

Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model.

B. Bahnson, D. Josse, J. D. Nicholson, 2004, Biochimica et biophysica acta.

Mouse monoclonal antibodies against paraoxon: potential reagents for immunoassay with constant immunochemical characteristics

K. Hunter, A. Brimfield, D. E. Lenz, 1985 .

Inhibition of rat cerebrum acetylcholinesterase isoenzymes after acute administration of soman.

D. M. Maxwell, D. Lenz, 1981, Biochemical pharmacology.

Purification of antibodies

E. P. Meier, L. Sternberger, D. Lenz, 1962 .

1-1-2004 Structure / function analyses of human serum paraoxonase ( HuPON 1 ) mutants designed from a DFPase-like homology model

D. Josse, J. D. Nicholson, David T. Yeung, 2013 .

Detection and quantification of the organophosphate insecticide paraoxon by competitive inhibition enzyme immunoassay.

K. Hunter, D. E. Lenz, D. Lenz, 1982, Life sciences.

The stability of soman and its stereoisomers in aqueous solution: Toxicological considerations

C. Broomfield, B. Maciver, D. Lenz, 1986, Archives of Toxicology.

Effect of carboxylesterase inhibition on carbamate protection against soman toxicity.

D. M. Maxwell, D. Lenz, K. Brecht, 1988, The Journal of pharmacology and experimental therapeutics.

Radiolabelled soman binding to sera from Rats, Guinea Pigs and Monkeys.

D. Cerasoli, D. M. Maxwell, D. Lenz, 2018, Toxicology letters.

Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation.

Meghan E. Kazanski, Melanie G. Kirkpatrick, C. Broomfield, 2010, Chemico-biological interactions.

Bioscavengers as a Pretreatment for Nerve Agent Exposure

D. Lenz, 2002 .

6 – Structure-activity relationships and anticholinesterase activity

D. M. Maxwell, D. Lenz, 1992 .

Acetylcholinesterase: new evidence for an acetyl-enzyme intermediate.

G. Hein, D. Lenz, 1970, Biochimica et Biophysica Acta.

Hypothesis for Synergistic Toxicity of Organophosphorus Poisoning‐induced Cholinergic Crisis and Anaphylactoid Reactions

T. Shih, J. Madsen, F. Cowan, 1996, Journal of applied toxicology : JAT.

Protective action of the serine protease inhibitor N‐tosyl‐L‐lysine chloromethyl ketone (TLCK) against acute soman poisoning

T. Shih, F. Cowan, C. Broomfield, 2001, Journal of applied toxicology : JAT.

Antibody quantitation using the unlabeled antibody enzyme immunoassay (UNLIM) method.

D. Lenz, 1981, Methods in enzymology.

Development of an immunoassay for diagnosis of exposure to toxic organophosphorus compounds

Jennifer K. Miller, D E Lenz, J K Miller, 2001, Journal of applied toxicology : JAT.

Rapid Production of Recombinant Proteins Utilizing the PERLXpress Platform

R. Eisenberg, G. Cohen, R. Welch, 2006 .

DNA aptamers developed against a soman derivative cross‐react with the methylphosphonic acid core but not with flanking hydrophobic groups

John G. Bruno, Taylor Phillips, C. Linn Cadieux, 2009, Journal of molecular recognition : JMR.

Structural and stereochemical specificity of mouse monoclonal antibodies to the organophosphorous cholinesterase inhibitor soman.

H. Benschop, C. van Dijk, K. Hunter, 1985, Molecular pharmacology.

The role of glutamate-199 in the aging of cholinesterase.

P. Taylor, B. P. Doctor, Z. Radić, 1993, Biochemical and biophysical research communications.

The development of immunoassays for detection of chemical warfare agents

L. Cook, A. Brimfield, D. Lenz, 1996 .

Specific soman-hydrolyzing enzyme activity in a clonal neuronal cell culture.

R. Ray, C. Broomfield, L. Boucher, 1988, Biochimica et biophysica acta.

Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure.

R. K. Gordon, M. Adler, Patrick F. Desmond, 2010, Chemico-biological interactions.

Effect of octanol:water partition coefficients of organophosphorus compounds on biodistribution and percutaneous toxicity

S. Czerwinski, S. Baskin, D. M. Maxwell, 2006, Journal of biochemical and molecular toxicology.