J. de Belleroche

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Investigation of G72 (DAOA) expression in the human brain

P. Maycox, F. Kelly, J. Kew, 2008, BMC psychiatry.

Overexpression of Heat Shock Protein 27 Reduces Cortical Damage after Cerebral Ischemia

David L. Thomas, M. Lythgoe, D. Gadian, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The Neuroprotective Effects of Heat Shock Protein 27 Overexpression in Transgenic Animals against Kainate-induced Seizures and Hippocampal Cell Death*

M. Akbar, D. Latchman, A. Lundberg, 2003, Journal of Biological Chemistry.

Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss.

M. Akbar, D. Latchman, R. Coffin, 2003, Brain research. Molecular brain research.

Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs.

D. Latchman, R. Coffin, M. Wagstaff, 1996, Brain research. Molecular brain research.

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

Robert H. Brown, F. Baas, A. Al-Chalabi, 2018, Neurobiology of Aging.

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS)

D. Wells, Ke Liu, J. Hildyard, 2018, Front. Mol. Biosci..

The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS)

J. de Belleroche, P. Paul, Praveen G. Paul, 2014, Front. Synaptic Neurosci..

Neuroprotective effects of copper/zinc-dependent superoxide dismutase against a wide variety of death-inducing stimuli and proapoptotic effect of familial amyotrophic lateral sclerosis mutations.

D. Latchman, R. Coffin, Y. Patel, 2002, Brain research. Molecular brain research.

Familial amyotrophic lateral sclerosis with a point mutation of SOD-1: intrafamilial heterogeneity of disease duration associated with neurofibrillary tangles.

R. Orrell, D. Hilton, A. King, 1995, Journal of neurology, neurosurgery, and psychiatry.

AMINO ACIDS IN SYNAPTIC VESICLES FROM MAMMALIAN CEREBRAL CORTEX: A REAPPRAISAL

J. Belleroche, H. Bradford, J. de Belleroche, 1973, Journal of neurochemistry.

Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase

C. Shaw, C. Vance, M. Falchi, 2010, Proceedings of the National Academy of Sciences.

Difficulties in distinguishing sporadic from familial amyotrophic lateral sclerosis

J. Habgood, R. Lane, J. de Belleroche, 1996, Annals of neurology.

Abnormal glycine metabolism in motor neurone disease: studies on plasma and cerebrospinal fluid.

R. Bandopadhyay, R. Lane, J. de Belleroche, 1993, Journal of the Royal Society of Medicine.

Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A

K. Rayner, T. Simard, D. Wells, 2008, Circulation research.

Serum heat shock protein 27 levels represent a potential therapeutic target for atherosclerosis: observations from a human cohort and treatment of female mice.

B. Chow, K. Wilson, K. Rayner, 2013, Journal of the American College of Cardiology.

Identification of PEX7 as the second gene involved in Refsum disease.

H. Waterham, R. Wanders, J. Haasjes, 2003, American journal of human genetics.

Variants in the zinc transporter-3 encoding gene (SLC30A3) in schizophrenia and bipolar disorder: Effects on brain glutamate–A pilot study

A. Young, D. Lythgoe, L. Jelen, 2022, Frontiers in Psychiatry.

Transport of amino acids and catecholamines in relation to metabolism and transmission.

H. Bradford, J. de Belleroche, 1976, Advances in experimental medicine and biology.

The stimulus‐induced release of acetylcholine from synaptosome beds and its calcium dependence

H. Bradford, J. de Belleroche, J. S. De Belleroche, 1972, Journal of neurochemistry.

The role of d-amino acids in amyotrophic lateral sclerosis pathogenesis: a review

J. Belleroche, J. de Belleroche, P. Paul, 2012, Amino Acids.

Elevated levels of amino acids in the CSF of motor neuron disease patients.

F C Rose, J de Belleroche, A Recordati, 1984, Molecular and Chemical Neuropathology.

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

D. Wells, Ke Liu, J. Hildyard, 2017, PloS one.

Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes.

J. De Belleroche, S. Adler, C. Nast, 2009, Endocrinology.

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Xun Hu, Kelly L. Williams, Christopher E. Shaw, 2008, Science.

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

Annelot M. Dekker, Robert H. Brown, F. Baas, 2016, Nature Genetics.

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

Xun Hu, Kelly L. Williams, Christopher E. Shaw, 2009, Science.

Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes

J. Belleroche, L. Montibeller, J. de Belleroche, 2018, Cell Stress and Chaperones.

Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset.

A. Morris, J. Mitchell, J. de Belleroche, 2009, Free radical biology & medicine.

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Robert H. Brown, R. Petersen, B. Boeve, 2016, Nature Communications.

Experimental approaches for elucidating co-agonist regulation of NMDA receptor in motor neurons: Therapeutic implications for amyotrophic lateral sclerosis (ALS).

J. de Belleroche, P. Paul, Praveen G. Paul, 2015, Journal of pharmaceutical and biomedical analysis.

A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia

H. Horvitz, J. De Belleroche, J. Belleroche, 2006, Neurology.

Allelic variants in the zinc transporter-3 gene, SLC30A3, a candidate gene identified from gene expression studies, show gender-specific association with schizophrenia

P. McKenna, A. Mortimer, A. Morris, 2014, European psychiatry.

Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes

J. Belleroche, L. Montibeller, J. de Belleroche, 2018, Cell Stress and Chaperones.

Transcription and pathway analysis of the superior temporal cortex and anterior prefrontal cortex in schizophrenia

C. Davies, M. Barnes, J. Huxley-Jones, 2011, Journal of neuroscience research.

Changes in expression of NMDA receptor subunits in the rat lumbar spinal cord following neonatal nerve injury

G. Mentis, L. Virgo, J. de Belleroche, 2000, Neuropathology and applied neurobiology.

Absence of an effect of histamine, noradrenaline and depolarizing agents on the levels of adenosine 3', 5'-monophosphate in nerve endings isolated from cerebral cortex.

H. Bradford, I. Das, J. de Belleroche, 1974, Biochemical pharmacology.

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

Annelot M. Dekker, Robert H. Brown, F. Baas, 2016, Nature Genetics.

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis

Robert H. Brown, M. Weale, F. Baas, 2017, Science Translational Medicine.

Down‐regulation of Dickkopf 3, a regulator of the Wnt signalling pathway, in elderly schizophrenic subjects

S. Hirsch, M. Akbar, S. Ftouh, 2005, Journal of neurochemistry.

Evaluation of neuronal loss, astrocytosis and abnormalities of cytoskeletal components of large motor neurons in the human anterior horn in aging

F. F. Cruz-Sánchez, E. Tolosa, F. cruz-Sánchez, 1998, Journal of Neural Transmission.

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

A. Malaspina, J. de Belleroche, N. Kaushik, 2001, Journal of neurochemistry.

Copper, zinc superoxide dismutase (SOD1) and its role in neuronal function and disease with particular relevance to motor neurone disease/amyotrophic lateral sclerosis.

R. Orrell, A. Malaspina, J. Mitchell, 1998, Biochemical Society transactions.

Absence of linkage between chromosome 21 loci and familial amyotrophic lateral sclerosis.

J. Hardy, H. Houlden, R. Lane, 1993, Journal of medical genetics.

Isolation and characterization of trinucleotide repeat containing partial transcripts in human spinal cord

F. Baas, M. Schalling, A. Malaspina, 1998, Neurogenetics.

Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis

Han-Jou Chen, Andrea Chai, G. Pennetta, 2010, The Journal of Biological Chemistry.

Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization.

A. Malaspina, J. de Belleroche, N. Kaushik, 2000, DNA and cell biology.

Cyclo-oxygenase-2 Messenger RNA Induction in Focal Cerebral Ischemia

M. Harrison, B. Aspey, J. de Belleroche, 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2.

John Mitchell, J. De Belleroche, R. Orrell, 2003, American journal of human genetics.

Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration.

M. Akbar, D. Latchman, D. Wells, 2001, Brain research. Molecular brain research.

Identification of PEX7 as the second gene involved in Refsum disease.

H. Waterham, R. Wanders, J. Haasjes, 2003, Advances in experimental medicine and biology.

Association studies indicate that protein disulfide isomerase is a risk factor in amyotrophic lateral sclerosis.

J. De Belleroche, C. Shaw, Bradley N Smith, 2013, Free radical biology & medicine.

Anticonvulsants and trifluoperazine inhibit the evoked release of GABA from cerebral cortex of rat at different sites.

J. De Belleroche, A. Dick, A. Wyrley-Birch, 1982, Life sciences.

Tissue‐selective regulation of protein homeostasis and unfolded protein response signalling in sporadic ALS

L. Montibeller, J. de Belleroche, Joo Kyung Kim, 2020, Journal of cellular and molecular medicine.

Heat Shock Protein 27 Protects Against Atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation

K. Rayner, T. Simard, D. Wells, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.

S. Tabrizi, R. Morimoto, D. Latchman, 2007, Human molecular genetics.

NMDA receptor mRNA correlation with antemortem cognitive impairment in schizophrenia.

S. Hirsch, A. Mortimer, J. de Belleroche, 1996, Neuroreport.

An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon 4.

J. Collinge, N. Katsanis, E. Fisher, 1995, Human molecular genetics.

Amyotrophic lateral sclerosis brain banking: a proposal to standardize protocols and neuropathological diagnostic criteria.

F. cruz-Sánchez, M. Rossi, J. de Belleroche, 1993, Journal of neural transmission. Supplementum.

Familial amyotrophic lateral sclerosis/motor neurone disease (FALS): a review of current developments.

R. Orrell, R Orrell, J de Belleroche, 1995, Journal of medical genetics.

Reply to Millecamps et al.: Elucidating the role of D amino acid oxidase in familial amyotrophic lateral sclerosis

A. Morris, J. de Belleroche, 2010, Proceedings of the National Academy of Sciences.

Pathogenesis of Parkinson's disease: emerging role of molecular chaperones.

R. Bandopadhyay, J. de Belleroche, 2010, Trends in molecular medicine.

Focal Ischemia Causes an Extensive Induction of Immediate Early Genes That Are Sensitive to MK‐801

B. Aspey, J. de Belleroche, M. Harrison, 1994, Stroke.

Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells.

J. De Belleroche, D. Latchman, Y. Patel, 2005, Brain research. Molecular brain research.

Excitotoxin induction of ornithine decarboxylase in cerebral cortex is reduced by phospholipase A2 inhibition.

I. M. Gardiner, I. Gardiner, J. de Belleroche, 1992, Life sciences.

Patterns of inheritance in familial ALS

R. Orrell, Lloyd Bradley, J. de Belleroche, 2005, Neurology.

Analysis of AMPA receptor subunit mRNA expression in control and ALS spinal cord.

S. Samarasinghe, L. Virgo, J. de Belleroche, 1996, Neuroreport.

Heat shock protein overexpression - effect on experimental stroke

M. Lythgoe, D. Gadian, L. van der Weerd, 2005 .

Nimodipine Has an Inhibitory Action on Neurotransmitter Release from Human Cerebral Arteries

J. De Belleroche, I. Porter, I. Gardiner, 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Chronic Over-Expression of Heat Shock Protein 27 Attenuates Atherogenesis and Enhances Plaque Remodeling: A Combined Histological and Mechanical Assessment of Aortic Lesions

K. Rayner, D. Tremblay, C. Kennedy, 2013, PloS one.

Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis

D. Latchman, R. Coffin, M. Wagstaff, 1998, The European journal of neuroscience.

Depletion of cortical cholecystokinin levels after excitotoxin injection into the nucleus basalis: sensitivity to MK-801.

R. Bandopadhyay, J. de Belleroche, 1995, European journal of pharmacology.

Reversal of Neurotoxin‐Induced Ornithine Decarboxylase Activity in Rat Cerebral Cortex by Nimodipine A Potential Neuroprotective Mechanism

I. M. Gardiner, J. de Belleroche, 1990, Stroke.

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

Annelot M. Dekker, Ashley R. Jones, F. Baas, 2016, Nature Genetics.

Cholecystokinin CCK(B) receptor mRNA isoforms: expression in schizophrenic brains.

S. Hirsch, N. Lindefors, O. Zachrisson, 1999, Neuroreport.

Serum heat shock protein 27 levels represent a potential therapeutic target for atherosclerosis: observations from a human cohort and treatment of female mice.

B. Chow, K. Wilson, K. Rayner, 2013, Journal of the American College of Cardiology.