J. Wilkinson

发表

Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.

Jian Sun, Wanli Lu, Jian Sun, 2006, Journal of medicinal chemistry.

Development of a robust reporter-based assay for the bioactivity determination of anti-VEGF therapeutic antibodies.

F. Zhang, F. Fan, Meng Li, 2016, Journal of pharmaceutical and biomedical analysis.

Comprehensive Survey of CDK Inhibitor Selectivity in Live Cells with Energy Transfer Probes

T. Willson, D. Drewry, C. Wells, 2019 .

Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.

Jian Sun, D. M. Penny, Wanli Lu, 2009, Biochemistry.

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.

Michelle R Arkin, Jennifer Hyde, M. Arkin, 2004, Journal of medicinal chemistry.

Quantifying CDK inhibitor selectivity in live cells

T. Willson, D. Drewry, C. Wells, 2020, Nature Communications.

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

T. Willson, S. Knapp, S. Müller, 2017, Cell chemical biology.

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Jen Q. Pan, K. Stegmaier, E. Scolnick, 2018, Science Translational Medicine.

Compound Profiling Using a Panel of Steroid Hormone Receptor Cell-Based Assays

David Thompson, David J. Thompson, K. Bi, 2008, Journal of biomolecular screening.

Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift

M. P. Killoran, K. Wood, Kris Zimmerman, 2018, ACS medicinal chemistry letters.

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

M. T. Beck, T. Willson, M. Robers, 2023, bioRxiv.

HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors.

T. Machleidt, K. Bi, Victoria Echeverria, 2008, Assay and drug development technologies.

Development and validation of a cell-based assay for the nuclear receptor retinoid-related orphan receptor gamma.

K. Bi, J. Wilkinson, T. Hallis, 2011, Assay and drug development technologies.

Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex

M. T. Beck, M. Robers, J. Vasta, 2023, Cell Chemical Biology.

DELs enable the development of BRET probes for target engagement studies in cells.

M. T. Beck, Wenji Su, Letian Kuai, 2023, Cell chemical biology.

Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET

S. Knapp, B. Berger, M. Robers, 2021, STAR protocols.