D. Thurmond

发表

Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex.

P. Halban, J. Pessin, M. Furukawa, 2003, Molecular endocrinology.

Munc18c Function Is Required for Insulin-Stimulated Plasma Membrane Fusion of GLUT4 and Insulin-Responsive Amino Peptidase Storage Vesicles

M. Kanzaki, J. Pessin, Ahmir H. Khan, 2000, Molecular and Cellular Biology.

Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance.

G. Shulman, J. Pessin, C. Yang, 2001, The Journal of clinical investigation.

Insulin-stimulated GLUT 4 translocation requires the CAP-dependent activation of TC 10

M. Kanzaki, R. Watson, A. Saltiel, 2001 .

Exocytosis Proteins: Typical and Atypical Mechanisms of Action in Skeletal Muscle

D. Thurmond, Jinhee H Hwang, 2022, Frontiers in Endocrinology.

DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle

V. Salunkhe, R. Veluthakal, Eunjin Oh, 2019, Diabetologia.

Exocytosis proteins as novel targets for diabetes prevention and/or remediation?

Arianne Aslamy, D. Thurmond, 2017, American journal of physiology. Regulatory, integrative and comparative physiology.

Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.

Zhanxiang Wang, D. Wiseman, W. Luo, 2012, Molecular endocrinology.

A Direct Interaction between Cdc42 and Vesicle-associated Membrane Protein 2 Regulates SNARE-dependent Insulin Exocytosis*

Angela K Nevins, D. Thurmond, 2005, Journal of Biological Chemistry.

Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cells.

Jingping Lu, A. Hudmon, L. Ramalingam, 2014, The Biochemical journal.

Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus.

R. Mirmira, N. Stull, Eunjin Oh, 2014, The Journal of clinical endocrinology and metabolism.

Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity

M. Verhage, A. Groffen, J. Brozinick, 2012, Diabetes.

Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes

L. Dimeglio, M. Duncan, F. Kandeel, 2018, The Journal of clinical endocrinology and metabolism.

DOC 2 B Levels in New-onset Type 1 Diabetes Exocytosis Protein DOC 2 B as a Biomarker of Type 1 Diabetes

F. Kandeel, Molly, M. El-Shahawy, 2018 .

Molecular basis for insulin-stimulated GLUT4 translocation

J. Pessin, D. Thurmond, 2001 .

Discrimination of GLUT4 vesicle trafficking from fusion using a temperature‐sensitive Munc18c mutant

J. Pessin, D. Thurmond, 2000, The EMBO journal.

Munc18c is not rate-limiting for glucose and long-chain fatty acid uptake in the heart

A. Bonen, W. Coumans, J. Glatz, 2009, Molecular and Cellular Biochemistry.

Insulin-regulated glucagon-like peptide-1 release from L cells: actin' out.

D. Thurmond, 2009, Endocrinology.

Regulation of the Action of Steroid/Thyroid Hormone Receptors by Medium-chain Fatty Acids*

R. Baillie, A. Goodridge, D. Thurmond, 1998, The Journal of Biological Chemistry.

Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance

D. Thurmond, Rekha Balakrishnan, 2022, International journal of molecular sciences.

used to determine the maximum NBD signal instead of Triton X-100. Rounds of fusion were determined by using a calibration curve which was prepared as described

M. Kanzaki, A. Saltiel, J. Pessin, 2000 .

Syntaxin 4 transgenic mice exhibit enhanced insulin-mediated glucose uptake in skeletal muscle.

Jason K. Kim, So-Young Park, Angela K Nevins, 2004, Diabetes.

Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1

J. Huss, P. Fueger, R. Veluthakal, 2022, Nature communications.

Potential Site Effects and Transgene Expression Discrepancies in Mouse Lifespan Studies.

Richard A. Miller, Eunjin Oh, D. Thurmond, 2015, Cell metabolism.

PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells

Zhanxiang Wang, D. Thurmond, 2012, FEBS open bio.

The Tyrosine Phosphorylation of Munc18c Induces a Switch in Binding Specificity from Syntaxin 4 to Doc2β*

S. Meroueh, Jenna L. Jewell, Eunjin Oh, 2008, Journal of Biological Chemistry.

A requirement for pak1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis.

Xin Wang, R. Veluthakal, Eunjin Oh, 2020, Metabolism: clinical and experimental.

Doc2β Is a Novel Munc18c-interacting Partner and Positive Effector of Syntaxin 4-mediated Exocytosis*

B. Ke, Eunjin Oh, D. Thurmond, 2007, Journal of Biological Chemistry.

Glucosamine‐induced insulin resistance is coupled to O‐linked glycosylation of Munc18c

Guoli Chen, Ping Liu, J. S. Elmendorf, 2003, FEBS letters.

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.

A. Klip, J. S. Elmendorf, L. Ramalingam, 2014, Biochemical pharmacology.

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.

Zhanxiang Wang, Stephanie M. Yoder, D. Thurmond, 2013, Biochemical pharmacology.

YES, a Src Family Kinase, Is a Proximal Glucose-specific Activator of Cell Division Cycle Control Protein 42 (Cdc42) in Pancreatic Islet β Cells*

Zhanxiang Wang, Stephanie M. Yoder, D. Thurmond, 2014, The Journal of Biological Chemistry.

Munc18c provides stimulus‐selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle

A. Bonen, J. Glatz, J. Luiken, 2012, FEBS letters.

Syntaxin 4 Mediates NF- k B Signaling and Chemokine Ligand Expression via Speci ﬁ c Interaction With I k B b

Diti Chatterjee Bhowmick, R. Veluthakal, Eunjin Oh, 2021 .

The chicken malic enzyme gene: structural organization and identification of triiodothyronine response elements in the 5'-flanking DNA.

S. Estrem, S. A. Klautky, A. Goodridge, 1996, Archives of biochemistry and biophysics.

Inflammatory stress of pancreatic beta cells drives release of extracellular heat‐shock protein 90α

J. Blum, C. Evans-Molina, Sarah N. Deffit, 2017, Immunology.

Nutritional and hormonal regulation of expression of the gene for malic enzyme.

R. Baillie, S. A. Klautky, A. Goodridge, 1996, Progress in nucleic acid research and molecular biology.

Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates

L. Ramalingam, Eunjin Oh, D. Thurmond, 2012, Cellular and Molecular Life Sciences.

Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

B. Yandell, A. Attie, J. Stoehr, 2011, PLoS genetics.

Conventional and Unconventional Mechanisms by which Exocytosis Proteins Oversee β-cell Function and Protection

Diti Chatterjee Bhowmick, R. Veluthakal, Eunjin Oh, 2021, International journal of molecular sciences.

Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake.

D. Thurmond, Karla E. Merz, 2020, Comprehensive Physiology.

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

W. Bush, R. Stein, D. Piston, 2014, Diabetes.

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

M. Kanzaki, A. Saltiel, J. Pessin, 2000, Nature.

Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis

D. Thurmond, 2007 .

Insulin resistance in tetracycline-repressible Munc18c transgenic mice.

G. Shulman, Jason K. Kim, Hyo-Jeong Kim, 2003, Diabetes.

Mechanisms of biphasic insulin-granule exocytosis – roles of the cytoskeleton, small GTPases and SNARE proteins

Zhanxiang Wang, Zhanxiang Wang, Debbie C. Thurmond, 2009, Journal of Cell Science.

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

Makoto Kanzaki, Alan R. Saltiel, Robert T. Watson, 2001, Nature.

Emerging Roles of Small GTPases in Islet β-Cell Function

R. Veluthakal, D. Thurmond, 2021, Cells.

VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells

Vaibhav Sidarala, A. Kowluru, C. Vlaar, 2015, Diabetologia.

Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation–induced pancreatitis

T. Liang, P. Thorn, Abrahim I. Orabi, 2017, The Journal of Biological Chemistry.

Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out

Ragadeepthi Tunduguru, D. Thurmond, 2017, Front. Endocrinol..

WNK1 Is a Novel Regulator of Munc18c-Syntaxin 4 Complex Formation in Soluble NSF Attachment Protein Receptor (SNARE)-mediated Vesicle Exocytosis*

M. Cobb, J. English, Eunjin Oh, 2007, Journal of Biological Chemistry.

Syntaxin 4 Overexpression Ameliorates Effects of Aging and High-Fat Diet on Glucose Control and Extends Lifespan.

Richard A. Miller, Eunjin Oh, D. Thurmond, 2015, Cell metabolism.

Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells

D. Thurmond, Michael A. Kalwat, 2013, Experimental & Molecular Medicine.

Munc18c: a controversial regulator of peripheral insulin action

L. Ramalingam, Eunjin Oh, Stephanie M. Yoder, 2014, Trends in Endocrinology & Metabolism.

Regulation of Insulin-stimulated GLUT4 Translocation by Munc18c in 3T3L1 Adipocytes*

J. Pessin, S. Okada, J. S. Elmendorf, 1998, The Journal of Biological Chemistry.

The good and bad effects of cysteine S-nitrosylation and tyrosine nitration upon insulin exocytosis: a balancing act.

D. Wiseman, D. Thurmond, 2012, Current diabetes reviews.

Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking

J. Pessin, S. Okada, J. S. Elmendorf, 1999, The Journal of Biological Chemistry.

Malic enzyme gene in chick embryo hepatocytes in culture: clofibrate regulates responsiveness to triiodothyronine.

A. Goodridge, T. Carlisle, D. Thurmond, 1996, Journal of lipid research.

The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets

L. Ramalingam, Zhanxiang Wang, Eunjin Oh, 2016, Diabetologia.

Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo*

J. Chernoff, D. Clapp, Zhanxiang Wang, 2011, The Journal of Biological Chemistry.

Stimulus-induced S-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis*

D. Wiseman, D. Thurmond, Michael A. Kalwat, 2011, The Journal of Biological Chemistry.

The Stimulus-induced Tyrosine Phosphorylation of Munc18c Facilitates Vesicle Exocytosis*

Eunjin Oh, D. Thurmond, 2006, Journal of Biological Chemistry.

Molecular machinery involved in the insulin-regulated fusion of GLUT4-containing vesicles with the plasma membrane (review).

J. Pessin, D. Thurmond, 2001, Molecular membrane biology.

Novel approaches to restore beta cell function in prediabetes and type 2 diabetes

S. Kahn, V. Salunkhe, R. Veluthakal, 2018, Diabetologia.

Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4.

Jenna L. Jewell, Eunjin Oh, D. Thurmond, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.

L. Quilliam, Zhanxiang Wang, Eunjin Oh, 2011, American journal of physiology. Endocrinology and metabolism.

Differential Phosphorylation of RhoGDI Mediates the Distinct Cycling of Cdc42 and Rac1 to Regulate Second-phase Insulin Secretion*

Zhanxiang Wang, D. C. Thurmond, D. Thurmond, 2009, The Journal of Biological Chemistry.

Glucose-stimulated Cdc42 Signaling Is Essential for the Second Phase of Insulin Secretion*

Zhanxiang Wang, Eunjin Oh, Debbie C Thurmond, 2007, Journal of Biological Chemistry.

Caveolin-1 Functions as a Novel Cdc42 Guanine Nucleotide Dissociation Inhibitor in Pancreatic β-Cells*

Angela K Nevins, D. Thurmond, 2006, Journal of Biological Chemistry.

Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion.

Debbie C Thurmond, Angela K Nevins, D. Thurmond, 2003, American journal of physiology. Cell physiology.

Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.

M. Quon, T. Hadden, A. Kowluru, 2005, Diabetes.

Munc18c Regulates Insulin-stimulated GLUT4 Translocation to the Transverse Tubules in Skeletal Muscle*

J. Pessin, C. Sigmund, Ahmir H. Khan, 2001, The Journal of Biological Chemistry.

J. S. Elmendorf, J. Brozinick, V. Salunkhe, 2017, The Journal of Biological Chemistry.

Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivity

L. Ramalingam, Eunjin Oh, D. Thurmond, 2014, Diabetologia.

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

V. Tagliabracci, J. S. Elmendorf, L. Ramalingam, 2011, The Journal of cell biology.

Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis

J. S. Elmendorf, Supriyo Bhattacharya, V. Salunkhe, 2022, Frontiers in Endocrinology.

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass

T. Becker, B. Roep, Solomon Afelik, 2018, Diabetes.

Fetal hyperglycemia and a high fat diet contribute to aberrant glucose tolerance and hematopoiesis in adulthood

C. Evans-Molina, S. Quinney, T. Kono, 2014, Pediatric Research.

Filamentous Actin Regulates Insulin Exocytosis through Direct Interaction with Syntaxin 4*

Zhanxiang Wang, Jenna L. Jewell, D. C. Thurmond, 2008, Journal of Biological Chemistry.

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells

Charles R. Evans, J. Kolls, E. Bernal-Mizrachi, 2023, Cell reports.

Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

O. Chepurny, G. Holz, C. Leech, 2018, Diabetes.

Editorial: Connecting the Dots Between Obesity, Diabetes and Cancer

X. Tong, D. Thurmond, Mei Kong, 2020, Frontiers in Endocrinology.

Recent insights into beta-cell exocytosis in type 2 diabetes.

H. Gaisano, D. Thurmond, 2019, Journal of molecular biology.

Cytoskeletal regulation of skeletal muscle glucose uptake 1 The actin-related p 41 ARC subunit contributes to p 21-activated kinase-1 ( PAK 1 ) – mediated glucose uptake into skeletal muscle cells

J. S. Elmendorf, J. Brozinick, V. Salunkhe, 2017 .

Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells.

D. C. Thurmond, B. Spurlin, D. Thurmond, 2006, Molecular endocrinology.

Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms*

M. Verhage, Eunjin Oh, D. Thurmond, 2012, The Journal of Biological Chemistry.

Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

Eunjin Oh, D. Thurmond, 2009, Diabetes.

Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance.

J. Pessin, Eunjin Oh, B. Spurlin, 2005, Diabetes.

Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates

L. Ramalingam, Eunjin Oh, D. Thurmond, 2013, Cellular and Molecular Life Sciences.

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function

V. Salunkhe, A. Moin, E. Olson, 2018, Diabetes.

Methylcellulose colony assay and single-cell micro-manipulation reveal progenitor-like cells in adult human pancreatic ducts

A. Riggs, J. Rawson, F. Kandeel, 2023, Stem cell reports.

Characterization of Thyroid Hormone Response Elements in the Gene for Chicken Malic Enzyme

A. Goodridge, D. Thurmond, 1998, The Journal of Biological Chemistry.

Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function

J. Huss, R. Veluthakal, D. Thurmond, 2023, Antioxidants.

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.

A. Klip, J. S. Elmendorf, L. Ramalingam, 2014, Biochemical pharmacology.

Exocytosis proteins as novel targets for diabetes prevention and/or remediation?

Arianne Aslamy, D. Thurmond, 2017, American journal of physiology. Regulatory, integrative and comparative physiology.

YES, a Src Family Kinase, Is a Proximal Glucose-specific Activator of Cell Division Cycle Control Protein 42 (Cdc42) in Pancreatic Islet β Cells*

Zhanxiang Wang, Stephanie M. Yoder, D. Thurmond, 2014, The Journal of Biological Chemistry.

Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release

S. Whiteheart, T. Schraw, Wangsun Choi, 2004, Thrombosis and Haemostasis.

A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin

R. Veluthakal, Eunjin Oh, D. Thurmond, 2023, International journal of molecular sciences.