J. Andrews

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Safety and pharmacokinetics of NXN-188 after single and multiple doses in five phase I, randomized, double-blind, parallel studies in healthy adult volunteers.

D. Vaughan, R. Medve, J. Speed, 2010, Clinical therapeutics.

N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects locomotor activity without producing a nigrostriatal lesion in the rat

A. Sahgal, J. Edwardson, J. Candy, 1984, Neuroscience Letters.

Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma.

C. Ware, A. E. Berger, J. Andrews, 1990, Journal of immunology.

NOVEL DISACCHARIDES CONTAINING SULFUR IN THE RING AND NITROGEN IN THE INTERGLYCOSIDE LINKAGE. CONFORMATION OF METHYL 5'-THIO-4-N-ALPHA -MALTOSIDE BOUN D TO GLYCOAMYLASE AND ITS ACTIVITY AS A COMPETITIVE INHIBITOR

B. Svensson, T. P. Frandsen, B. M. Pinto, 1995 .

Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.

F. Porreca, S. Maddaford, S. Rakhit, 2011, Journal of medicinal chemistry.

Synthesis, and in vitro and in vivo muscarinic pharmacological properties of a series of 1,6-dihydro-5-(4H)-pyrimidinone oximes.

T. de Boer, G. Ruigt, P. Pintar, 1998, Bioorganic & medicinal chemistry.

Effects of charcoal on dissociation kinetics of nuclear and cytosolic steroid-receptor complexes from hen oviduct.

A. Wolfson, J. Andrews, M. Hutchison, 1990, Journal of receptor research.

The effects of thyrotropin releasing hormone on rats with lesions of the mesolimbic and nigrostriatal dopamine systems

A. Sahgal, J. Andrews, 1985, Physiology & Behavior.

3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.

F. Porreca, S. Maddaford, S. Rakhit, 2011, Bioorganic & medicinal chemistry letters.

NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with μ-Opioid Agonist Activity.

S. Maddaford, S. Rakhit, B. Green, 2012, ACS medicinal chemistry letters.

Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.

S. Maddaford, S. Rakhit, J. Ramnauth, 2007, Bioorganic & medicinal chemistry letters.

Specific nuclear uptake of intracellularly-produced estrogen by rat granulosa cells.

A. Wolfson, E. Roquemore, J. Andrews, 1990, Journal of steroid biochemistry.

Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines.

S. Levy, M. Nelson, B. Park, 1993, Journal of medicinal chemistry.

Synthesis of a thio analogue of n-propyl kojibioside, a potential glucosidase inhibitor *

B. M. Pinto, J. Andrews, B. Pinto, 1995 .

Oligosaccharides corresponding to the antigenic determinants of the β-haemolytic Streptococci Group A. Part 2. Synthesis and 2D nuclear magnetic resonance analysis of a branched tetrasaccharide hapten

B. M. Pinto, J. Andrews, 1990 .

Excitatory Amino Acids and Anxiety

D. Stephens, L. Turski, H. Schneider, 1991 .

Synthesis and Enzymic Activity of Novel Glycosidase Inhibitors Containing Sulfur and Selenium

B. Svensson, B. M. Pinto, S. Mehta, 1995 .

9-Iodo-o-carborane

Maitland Jones, J. Zayas, J. Andrews, 1985 .

Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.

F. Porreca, S. Maddaford, S. Rakhit, 2012, Journal of Medicinal Chemistry.

Net triglyceride synthesis by rabbit cornea in vitro.

T. Kuwabara, J. Andrews, 1961, Biochimica et biophysica acta.

ANALYSIS OF VOLATILE FOOD FLAVORS BY GAS-LIQUID CHROMATOGRAPHY. I. THE VOLATILE COMPONENTS FROM DRY BLUE CHEESE AND DRY ROMANO CHEESE

J. Coffman, J. Andrews, Donald E. Smith, 1960 .

Possible confounding influence of strain, age and gender on cognitive performance in rats.

J. Andrews, 1996, Brain research. Cognitive brain research.

The effects of thyrotropin releasing hormone on a visual discrimination task in rats

A. Sahgal, J. Andrews, 1984, Pharmacology Biochemistry and Behavior.

Central administration of thyrotropin-releasing hormone and histidyl-proline-diketopiperazine disrupts the acquisition of a food rewarded task by a non-aversive action

A. Sahgal, J. Andrews, 1983, Regulatory Peptides.

The effects of thyrotropin-releasing hormone, metabolites and analogues on locomotor activity in rats

A. Sahgal, J. Andrews, 1983, Regulatory Peptides.

The Differential Effects of Atypical Antipsychotics on Prolactin Elevation Are Explained by Their Differential Blood-Brain Disposition: A Pharmacological Analysis in Rats

S. Kapur, A. Megens, X. Langlois, 2002, Journal of Pharmacology and Experimental Therapeutics.

First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.

F. Porreca, S. Maddaford, S. Rakhit, 2012, Journal of medicinal chemistry.

Novel Hetero-analogs of Methyl Maltoside Containing Sulfur and Selenium as Potential Glycosidase Inhibitors

B. M. Pinto, S. Mehta, B. Johnston, 1994 .

Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.

D. Dodick, G. Dussor, F. Porreca, 2010, Brain : a journal of neurology.

The effects of vasopressin on positively rewarded responding and on locomotor activity in rats

A. Sahgal, B. A. Newton, J. Andrews, 1983, Neuropeptides.

CHAPTER 5 – DRUG DISCRIMINATION MODELS IN ANXIOLYTIC AND ANTIDEPRESSANT RESEARCH

D. Stephens, J. Andrews, 1991 .

Drug discrimination models in anxiety and depression.

D. Stephens, J. Andrews, 1990, Pharmacology & therapeutics.

Effects of naloxone and diprenorphine on amphetamine-stimulated behavior in guinea pigs and rats

S. Holtzman, J. Andrews, 1987, Neuropharmacology.

Chemistry and pharmacology of novel antidepressants

R. Pinder, J. Andrews, 2001 .

NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models

J. Olesen, I. Jansen-Olesen, Saurabh Gupta, 2013, Cephalalgia : an international journal of headache.

Performance of four different rat strains in the autoshaping, two-object discrimination, and swim maze tests of learning and memory

C. Broekkamp, A. Princen, J. Andrews, 1995, Physiology & Behavior.

Effects of NBM lesions with two neurotoxins on spatial memory and autoshaping

T. Steckler, J. Andrews, J. Turner, 1993, Pharmacology Biochemistry and Behavior.

Abecarnil, a metabolically stable, anxioselective beta-carboline acting at benzodiazepine receptors.

D. Stephens, L. Turski, L. H. Jensen, 1990, The Journal of pharmacology and experimental therapeutics.

Matching to sample in rats using projected visual stimuli

J. S. Andrews, J.H.M. Jansen, J. Andrews, 1996 .

Substantia nigra regulates action of antiepileptic drugs

Z. Bortolotto, E. Cavalheiro, P. Löschmann, 1990, Brain Research.

Effects of disrupting the cholinergic system on short-term spatial memory in rats

A. Princen, J. Andrews, J. Jansen, 1994, Psychopharmacology.

The use of bonded-phase extraction columns for rapid sample preparation of benzodiazepines and metabolites from serum for HPLC analysis.

J. Andrews, T. J. Good, 1981, Journal of chromatographic science.

5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.

A. Sleight, M. Bös, V. Mutel, 1998, The Journal of pharmacology and experimental therapeutics.

Effects of stress and beta-funal trexamine pretreatment on morphine analgesia and opioid binding in rats.

E. J. Simon, J. Hiller, S. Holtzman, 1987, Life sciences.

Effects of d-amphetamine, morphine, naloxone, and drug combinations on visual discrimination in rats

S. Holtzman, J. Andrews, 2004, Psychopharmacology.

The interaction of d-amphetamine and naloxone differs for rats trained on separate fixed-interval or fixed-ratio schedules of reinforcement

S. Holtzman, J. Andrews, 1987, Pharmacology Biochemistry and Behavior.

Discriminative stimulus properties of the stereoisomers of the phosphodiesterase inhibitor rolipram

D. Stephens, H. Schneider, M. Yamaguchi, 1995, Pharmacology Biochemistry and Behavior.

5-HT 2 C Receptor Agonists : Pharmacological Characteristics and Therapeutic Potential

A. Sleight, M. Bös, V. Mutel, 1998 .

Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.

F. Porreca, S. Maddaford, S. Rakhit, 2012, European journal of medicinal chemistry.

Chapter 4.4 - Glucocorticoid antagonists and depression

J. Andrews, 2005 .

Synthesis and muscarinic activities of 3-(pyrazolyl)-1,2,5,6-tetrahydropyridine derivatives.

T. de Boer, R. Plate, J. Andrews, 1996, Bioorganic & medicinal chemistry.

Synthesis and muscarinic M3 pharmacological activities of 1-azabicyclo[2.2.2]octan-3-one oxime derivatives.

T. de Boer, R. Plate, J. Andrews, 1996, Bioorganic & medicinal chemistry.

Effects of selective antagonism or depletion of the cholinergic system on visual discrimination performance in rats

J. Vossen, W. Drinkenburg, J. Andrews, 1995, Behavioural Pharmacology.

Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

F. Porreca, M. De Felice, S. Maddaford, 2011, Journal of medicinal chemistry.

COMPREG: A BASIC program to test for differences between several linear regression lines

G. N. Wiggans, J. S. Andrews, A. Sahgal, 1983 .

Synthesis and relative potencies of new constrained CRF antagonists.

Y. Taché, W. Vale, J. Rivier, 1993, Journal of medicinal chemistry.

The effects of serotonergic drugs on short-term spatial memory in rats

J. Andrews, J. Jansen, 1994, Journal of psychopharmacology.

Conformational analysis of maltoside heteroanalogues using high-quality NOE data and molecular mechanics calculations. Flexibility as a function of the interglycosidic chalcogen atom

T. Weimar, U. Kreis, J. Andrews, 1999 .

The effects of ibotenic acid lesions of the basal forebrain on visual discrimination performance in rats

D. Stephens, M. Grützner, J. Andrews, 1994, Brain Research Bulletin.

Effects of cholinergic and non-cholinergic drugs on visual discrimination and delayed visual discrimination performance in rats

D. Stephens, M. Grützner, J. Andrews, 2005, Psychopharmacology.

Block of fear conditioning induced by habituation or extinction

R. Leaf, J. Andrews, Robert J. Kayser, 1968 .

A COMPARISON OF THE STAINING OF LIPID DROPLETS IN THE MOUSE OVARY BY THE SCHIFF REACTION AND BY THE ASHBEL-SELIGMAN CARBONYL REACTION

H. W. Deane, J. Andrews, 1953, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models

J. Olesen, I. Jansen-Olesen, Saurabh Gupta, 2013, Cephalalgia : an international journal of headache.

Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).

F. Porreca, S. Rakhit, J. Ramnauth, 2012, Bioorganic & medicinal chemistry letters.

1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.

F. Porreca, S. Rakhit, David K. H. Lee, 2012, Journal of medicinal chemistry.