U. Bömer

发表

A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy

Michael Erkelenz, H. Weinmann, A. Rottmann, 2022, Bioconjugate chemistry.

The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17.

N. Pfanner, N. Zufall, A. Maarse, 1996, Journal of molecular biology.

The Sorting Route of Cytochrome b 2Branches from the General Mitochondrial Import Pathway at the Preprotein Translocase of the Inner Membrane*

K. Dietmeier, N. Pfanner, B. Guiard, 1997, The Journal of Biological Chemistry.

Tom5 functionally links mitochondrial preprotein receptors to the general import pore

K. Dietmeier, N. Pfanner, F. Lottspeich, 1997, Nature.

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane

N. Pfanner, P. Dekker, A. Maarse, 1997, The EMBO journal.

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models

Andreas Hägebarth, Ningshu Liu, O. Politz, 2017, International journal of cancer.

Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins

A. Merlin, N. Pfanner, F. Martin, 1998, The EMBO journal.

Derives de triazolopyridines

P. Lienau, G. Siemeister, M. Koppitz, 2010 .

Mitochondrial Inner Membrane Bound Pet1402 Protein Is Rapidly Imported into Mitochondria and Affects the Integrity of the Cytochrome Oxidase and Ubiquinol-Cytochrome c Oxidoreductase Complexes

E. Pratje, U. Bömer, Wolfram Meyer, 1997, Biological chemistry.

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer

H. Briem, P. Lienau, P. Nussbaumer, 2017, ChemMedChem.

The sorting signal of cytochrome b2 promotes early divergence from the general mitochondrial import pathway and restricts the unfoldase activity of matrix Hsp70.

N. Pfanner, B. Guiard, F. Gärtner, 1995, The EMBO journal.

Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.

H. Briem, P. Lienau, U. Klar, 2020, Journal of medicinal chemistry.

Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer.

H. Briem, P. Lienau, M. Schäfer, 2021, Journal of medicinal chemistry.

The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models

Clara D. Christ, E. Nevedomskaya, H. Briem, 2021, Cellular Oncology.

BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity.

P. Lienau, D. Mumberg, C. Lange, 2017, Cancer letters.

The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models

Clara D. Christ, E. Nevedomskaya, H. Briem, 2021, Cellular Oncology.

High‐Throughput Screening for Kinase Inhibitors

Ulf Bömer, Oliver von Ahsen, O. von Ahsen, 2005, Chembiochem : a European journal of chemical biology.

The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70–Tim44

N. Pfanner, F. Martin, B. Guiard, 1997, The EMBO journal.

Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway‐related role in protein import.

K. Dietmeier, N. Pfanner, F. Lottspeich, 1996, The EMBO journal.

Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor

S. Grünewald, M. Lobell, K. Lustig, 2018, ChemMedChem.

Discovery of BAY-985 a highly selective TBK1/Ikkε inhibitor.

F. Prinz, H. Briem, D. Panne, 2019, Journal of medicinal chemistry.

The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage–Inducing or Repair–Compromising Therapies in Preclinical Cancer Models

A. Schlicker, P. Lienau, B. Haendler, 2019, Molecular Cancer Therapeutics.

BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.

H. Briem, P. Lienau, S. Hammer, 2021, Journal of medicinal chemistry.

Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats

K. Dietmeier, N. Pfanner, U. Bömer, 1996, FEBS letters.

A Cost-Effective Solution to Reduce Dead Volume of a Standard Dispenser System by a Factor of 5

Christian Bergsdorf, Nadine Gewiese, Andreas Stolz, 2006, Journal of biomolecular screening.

The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences

N. Pfanner, N. Zufall, M. Moczko, 1997, Molecular and cellular biology.

Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence.

N. Pfanner, B. Guiard, T. Krimmer, 2000, Molecular biology of the cell.

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

P. Lienau, C. Arrowsmith, M. Vedadi, 2023, Journal of medicinal chemistry.

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane 1996

N. Pfanner, A. Maarse, M. Meijer, 2013 .