Xin Chen

发表

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

Gregory McAllister, Sven Schuierer, Gregory R. Hoffman, 2017, Scientific Reports.

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.

Y. Mishina, E. Martin, W. Shao, 2016, Journal of medicinal chemistry.

"Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.

W. Shao, J. Duca, K. Hurov, 2017, Journal of medicinal chemistry.

Bisindole natural products: A vital source for the development of new anticancer drugs.

Mengwei Xu, Guang Yang, Rui Peng, 2022, European journal of medicinal chemistry.

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

M. Schirle, Edmund M. Harrington, W. Forrester, 2021, bioRxiv.

Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective.

Q. You, Xiaoke Guo, Xin Chen, 2021, Journal of medicinal chemistry.

Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia.

Q. You, Zhengyu Jiang, Dongdong Li, 2021, Journal of medicinal chemistry.

Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.

Q. You, Zhengyu Jiang, Dongdong Li, 2019, European journal of medicinal chemistry.

Development of sertraline analogues as potential anti-ischemic stroke agents.

Ting Zhou, Dongting Zhangsun, Qin Ouyang, 2023, European journal of medicinal chemistry.

Phototoxicity─Medicinal Chemistry Strategies for Risk Mitigation in Drug Discovery.

D. Bauer, Kayo Yasoshima, T. J. Harrison, 2023, Journal of medicinal chemistry.

Tetrahydro-β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity.

Aubry K. Miller, Raphael R. Steimbach, X. Wang, 2023, European journal of medicinal chemistry.

Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity.

Q. You, Zhengyu Jiang, Dongdong Li, 2021, European journal of medicinal chemistry.