E. Meredith

发表

Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen.

Scott A. Busby, Daniel S. Palacios, W. Weihofen, 2017, Bioorganic & medicinal chemistry letters.

Core Replacements in a Potent Series of VEGFR-2 Inhibitors and Their Impact on Potency, Solubility, and hERG.

K. Gunderson, N. Mainolfi, K. Anderson, 2016, ACS medicinal chemistry letters.

Chapter 2 Synthesis of geldanamycin using glycolate aldol reactions

M. Andrus, E. Meredith, E. Hicken, 2005 .

Selective synthesis of the para-quinone region of geldanamycin.

J. Cannon, M. Andrus, Bryon Simmons, 2003, Organic letters.

Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions.

B. V. Soma Sekhar, M. Andrus, Bryon Simmons, 2002, Organic letters.

Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction.

M. Andrus, E. Meredith, B. Sekhar, 2001, Organic letters.

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.

G. Ksander, D. Rigel, A. Jeng, 2013, ACS medicinal chemistry letters.

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.

C. Springer, G. Ksander, D. Rigel, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid

M. Andrus, Jing Liu, E. Meredith, 2003 .

3,5-diarylazoles as novel and selective inhibitors of protein kinase D.

I. Enyedy, T. McKinsey, N. Pagratis, 2011, Bioorganic & medicinal chemistry letters.

Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).

Daniel S. Palacios, W. Weihofen, Xin Chen, 2019, ACS medicinal chemistry letters.

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates

Daniel S. Palacios, M. P. Dillon, T. Abrams, 2018, ACS medicinal chemistry letters.

Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors.

D. Bednarczyk, Y. Cho, S. Skolnik, 2022, Journal of medicinal chemistry.

Identification of orally available naphthyridine protein kinase D inhibitors.

I. Enyedy, T. McKinsey, Margaret R Pancost, 2010, Journal of medicinal chemistry.

Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin: asymmetric glycolate aldol reactions and biological evaluation.

M. Andrus, Wei-Ping Ma, Bryon Simmons, 2003, The Journal of organic chemistry.

Anti-selective glycolate aldol additions with an oxapyrone boron enolate.

N. K. Dalley, M. Andrus, E. Meredith, 2000, Organic letters.

Glycolate aldol reactions with boron enolates of bis-4-methoxyphenyl dioxanone

M. Andrus, E. Meredith, B. Sekhar, 2002 .

ChemInform Abstract: Highly Selective syn Glycolate Aldol Reactions with Boron Enolates of Masamune Norephedrine Esters.

M. Andrus, E. Meredith, B. Sekhar, 2001 .

Design and Synthesis of Potent Sensitizers of Gram-Negative Bacteria Based on a Cholic Acid Scaffolding

P. Savage, Chunhong Li, E. Meredith, 1998 .

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2015, Journal of medicinal chemistry.

A small-molecule inhibitor of C5 complement protein

M. Schirle, Mitsunori Kato, G. Michaud, 2019, Nature Chemical Biology.

Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation.

T. Dryja, B. Jaffee, Yubin Qiu, 2014, Investigative ophthalmology & visual science.

Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.

I. Enyedy, T. McKinsey, D. Lemon, 2010, Journal of medicinal chemistry.

Full-length myocilin protein is purified from mammalian cells as a dimer.

V. Saenz-Vash, M. J. Romanowski, Y. Wang, 2018, Protein expression and purification.

Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells

D. Rice, T. Nicholson, V. Saenz-Vash, 2018, The Journal of Biological Chemistry.

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

T. McKinsey, D. Lemon, J. Chapo, 2010, FEBS letters.

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2018, Journal of medicinal chemistry.

Lack of Involvement of CEP Adducts in TLR Activation and in Angiogenesis

B. Jaffee, R. Cepeda, Yubin Qiu, 2014, PLoS ONE.