G. Filacchioni

发表

Synthesis of some 2-aryl-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-ones as tools to define the essential pharmacophoric descriptors of a benzodiazepine receptor ligand.

C. Martini, A. Lucacchini, D. Catarzi, 1995, Journal of medicinal chemistry.

4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.

S. Moro, Erika Morizzo, C. Martini, 2006, Journal of medicinal chemistry.

Tricyclic heteroaromatic systems: [1]benzopyrano-pyrazol-4-ones as benzodiazepine receptor ligands.

C. Martini, A. Lucacchini, S. Gelli, 1991, Journal of pharmaceutical sciences.

Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists.

C. Costagli, A. Galli, D. Catarzi, 2009, Chemical & pharmaceutical bulletin.

Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: Synthesis and structure-activity relationships.

C. Costagli, A. Galli, Ombretta Lenzi, 2008, Bioorganic & medicinal chemistry.

Synthesis and pharmacological studies at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring.

C. Costagli, A. Galli, F. R. Calabri, 2005, European journal of medicinal chemistry.

Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A(2A) adenosine receptor antagonists.

C. Martini, A. Lucacchini, L. Trincavelli, 2003, Bioorganic & medicinal chemistry.

Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and of their constrained analogue imidazo.

C. Costagli, A. Galli, D. Catarzi, 2001, European journal of medicinal chemistry.

Synthesis and A1 and A2A adenosine binding activity of some pyrano[2,3-c]pyrazol-4-ones.

C. Martini, A. Lucacchini, F. Melani, 1998, Farmaco.

Tricyclic Heteroaromatic Systems. Pyrazolo[3,4‐c]quinolin‐4‐ones and Pyrazolo[3,4‐c]quinoline‐1,4‐diones: Synthesis and Benzodiazepine Receptor Activity

C. Costagli, A. Galli, D. Catarzi, 1997, Archiv der Pharmazie.

Synthesis of some tricyclic heteroaromatic systems and their A1 and A2a adenosine binding activity

C. Martini, A. Lucacchini, D. Catarzi, 1995 .

Tricyclic heteroaromatic systems. 5H-1,2,3-triazolo[5,1-c][1,4]benzodiazepine

F. Melani, L. Cecchi, V. Colotta, 2009 .

Synthesis of 2-substituted-6,8-dichloro-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-1,1-d ioxides and -1-oxides as glycine-NMDA receptor antagonists.

C. Costagli, A. Galli, D. Catarzi, 1998, Farmaco.

Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.

S. Moro, Erika Morizzo, F. Pedata, 2009, Journal of medicinal chemistry.

1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.

S. Moro, F. Deflorian, C. Martini, 2004, Journal of medicinal chemistry.

Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.

V. Carlá, C. Costagli, A. Galli, 2004, Journal of medicinal chemistry.

Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists.

V. Carlá, C. Costagli, A. Galli, 2002, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 1-aminophthalazinium salts as GABAA receptor antagonists

A. Galli, F. Mori, D. Catarzi, 1994 .

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.

S. Moro, C. Martini, S. Paoletta, 2011, Journal of medicinal chemistry.

1,2,4-Triazolo[1,5-a]quinoxaline derivatives: synthesis and biological evaluation as adenosine receptor antagonists.

C. Martini, A. Lucacchini, L. Trincavelli, 2004, Farmaco.

1,2,4-Triazolo[1,5-a]quinoxaline as a Versatile Tool for the Design of Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Biological Evaluation, and Molecular Modeling Studies of 2-(Hetero)aryl- and 2-Carboxy-Substitued Derivatives

S. Moro, C. Martini, L. Trincavelli, 2005 .

Structure-activity relationships of 1,2,4-triazolo[1,5-a] quinoxalines and their 1-deaza analogues imidazo[1,2-a]quinoxalines at the benzodiazepine receptor.

C. Martini, A. Lucacchini, L. Giusti, 1994, Journal of Medicinal Chemistry.

1,3-Diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones. 4. Synthesis and specific inhibition of benzodiazepine receptor binding.

C. Martini, A. Lucacchini, F. Melani, 1987, Journal of medicinal chemistry.

Pyrazolo[4,5-c]quinolines. 2. Synthesis and specific inhibition of benzodiazepine receptor binding.

C. Martini, A. Lucacchini, F. Melani, 1986, Journal of medicinal chemistry.

1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation, and molecular modeling study.

S. Moro, F. Deflorian, C. Costagli, 2005, Bioorganic & medicinal chemistry.

Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand.

C. Costagli, A. Galli, D. Catarzi, 1996, Journal of medicinal chemistry.

Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.

S. Moro, F. Deflorian, C. Ghelardini, 2006, Journal of medicinal chemistry.

Tricyclic heteroaromatic systems: synthesis, [3H]flunitrazepam brain membrane binding inhibition, and structure-activity relationships of 2,3-dihydro-2-aryl-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones.

C. Martini, G. Giannaccini, A. Lucacchini, 1989, Journal of pharmaceutical sciences.

The correct synthesis of 2,3-dihydro-2-aryl-4-r-[1]benzopyrano[4,3-c]pyrazole-3-ones.

F. Melani, G. Palazzino, L. Cecchi, 1987 .

Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines.

C. Martini, A. Lucacchini, D. Catarzi, 1995, Journal of medicinal chemistry.

3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.

C. Costagli, A. Galli, F. R. Calabri, 2004, Bioorganic & medicinal chemistry letters.

Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.

K. Varani, G. Cristalli, F. Vincenzi, 2011, Bioorganic & medicinal chemistry.

New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.

S. Moro, Erika Morizzo, F. Pedata, 2007, Journal of medicinal chemistry.

Synthesis of 5H‐10,11‐dihydropyrazolo[5,1‐c]‐[1,4]benzodiazepinederivatives. II

F. Melani, L. Cecchi, G. Filacchioni, 1984 .

SYNTHESIS OF 5H-PYRAZOLO(5,1-C)(1,4)BENZODIAZEPINE

L. Cecchi, G. Filacchioni, 1983 .

Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists.

K. Lingenhöhl, S. Ofner, Ombretta Lenzi, 2010, Chemical & pharmaceutical bulletin.

Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptor antagonists.

Jacopo Sgrignani, P. Gratteri, C. Costagli, 2008, Chemical & pharmaceutical bulletin.

Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.

S. Moro, Erika Morizzo, F. Pedata, 2008, Bioorganic & medicinal chemistry.

1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.

S. Moro, C. Martini, L. Trincavelli, 2005, Journal of medicinal chemistry.

Synthesis of 1,5-diaryl-3-methyl-1H-pyrazolo[4,5-c]isoquinolines and studies of binding to specific peripheral benzodiazepine binding sites.

C. Martini, G. Giannaccini, A. Lucacchini, 1989, Journal of pharmaceutical sciences.

Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies.

K. Varani, G. Cristalli, F. Vincenzi, 2009, Bioorganic & medicinal chemistry.

2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.

S. Moro, K. Varani, C. Corciulo, 2013, Journal of medicinal chemistry.

Tricyclic Heteroaromatic Systems. 1,2,4‐Triazolo[4,3‐a]quinoxalines and 1,2,4‐Triazino[4,3‐a]quinoxalines: Synthesis and Central Benzodiazepine Receptor Activity

C. Costagli, A. Galli, D. Catarzi, 1997, Archiv der Pharmazie.

Atrazine Metabolism by Nocardia: Elucidation of Initial Pathway and Synthesis of Potential Metabolites

M. Giardi, G. Filacchioni, M. C. Giardina, 1982 .

Chemical and Biological Degradation of Primary Metabolites of Atrazine by a Nocardia Strain

M. Giardi, G. Filacchioni, M. C. Giardina, 1985 .

4-Amino-2-chloro-1,3,5-triazine: a new metabolite of atrazine by a soil bacterium.

M. Giardi, G. Filacchioni, M. C. Giardina, 1980 .

Synthesis and structure-activity relationships of a new set of 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as adenosine receptor antagonists.

C. Martini, A. Lucacchini, L. Trincavelli, 2003, Bioorganic & medicinal chemistry.

Benzodiazepine binding activity of some tricyclic heteroaromatic systems to define the hydrogen bonding strength of the proton donors of the receptor site

C. Costagli, A. Galli, F. Melani, 1996 .

Structure‐Activity Relationship Studies of Novel Pyrazolo[1,5‐c][1,3]benzoxazines: Synthesis and Benzodiazepine Receptor Affinity

C. Costagli, A. Galli, D. Catarzi, 1996, Archiv der Pharmazie.

7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists.

V. Carlá, C. Costagli, A. Galli, 2000, Journal of medicinal chemistry.

Tricyclic heteroaromatic systems. 1,2,3,4-tetrahydropyrazolo[4,3-c][l]benzazepin-1-ones as potential antitumor agents

F. Melani, G. Palazzino, L. Cecchi, 1989 .

Tricyclic heterocyclic systems: Pyrazolo[5′,4′:4,5]‐and pyrazolo‐[3′,4′:4,5]pyrano[2,3‐b]pyridine derivatives

F. Melani, G. Palazzino, L. Cecchi, 1988 .

Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships.

C. Martini, G. Giannaccini, A. Lucacchini, 1990, Journal of Medicinal Chemistry.

Tricyclic Heteroaromatic Systems. (1)Benzopyranopyrrol‐4‐ones and (1)Benzopyrano‐1,2,3‐triazol‐4‐ones as Benzodiazepine Receptor Ligands. Synthesis and Structure‐Activity Relationships.

C. Martini, G. Giannaccini, A. Lucacchini, 1991 .

1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.

C. Martini, A. Lucacchini, V Colotta, 2000, Journal of medicinal chemistry.

Atrazine Metabolism by Nocardia: Elucidation of Initial Pathway and Synthesis of Potential Metabolites

M. Giardi, G. Filacchioni, M. C. Giardina, 1982 .

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.

S. Moro, Erika Morizzo, K. Varani, 2009, Journal of medicinal chemistry.

Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine skeleton as a key study.

S. Moro, Erika Morizzo, K. Varani, 2007, Journal of medicinal chemistry.

2-aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists.

S. Moro, C. Martini, F. R. Calabri, 2005, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.

C. Martini, A. Lucacchini, L. Trincavelli, 2000, Journal of medicinal chemistry.

Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.

K. Varani, G. Cristalli, F. Vincenzi, 2013, Bioorganic & medicinal chemistry.

Tandem 3D-QSARs approach as a valuable tool to predict binding affinity data: design of new Gly/NMDA receptor antagonists as a key study.

Stefano Moro, Magdalena Bacilieri, Flavia Varano, 2007, Journal of chemical information and modeling.

Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173.

C. Costagli, A. Galli, D. Catarzi, 2001, Journal of medicinal chemistry.

4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones: excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity.

C. Costagli, D. Catarzi, L. Cecchi, 1999, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of a Series of Quinazoline‐2‐carboxylic Acids and Quinazoline‐2,4‐diones as Glycine‐NMDA Antagonists: A Pharmacophore Model Based Approach

C. Costagli, A. Galli, D. Catarzi, 1997, Archiv der Pharmazie.

4‐Amino‐6‐benzylamino‐1,2‐dihydro‐2‐phenyl‐1,2,4‐triazolo[4,3‐α]‐quinoxalin‐1‐one: A New A2A Adenosine Receptor Antagonist with High Selectivity versus A1 Receptors

C. Martini, L. Trincavelli, D. Catarzi, 1999, Archiv der Pharmazie.

4‐Amino‐6‐benzylamino‐1,2‐dihydro‐2‐phenyl‐1,2,4‐triazolo [4,3‐a]quinoxalin‐1‐one: A New A2A Adenosine Receptor Antagonist with High Selectivity versus A1 Receptors.

C. Martini, A. Lucacchini, L. Trincavelli, 1999 .