T. Miles

发表

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2018, Nature.

Optimisation of a key cross-coupling reaction towards the synthesis of a promising antileishmanial compound

I. Gilbert, A. Moure, Michael G. Thomas, 2019, Tetrahedron letters.

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, E. Minthorn, 2016, Bioorganic & medicinal chemistry letters.

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, E. Minthorn, 2013, Bioorganic & medicinal chemistry letters.

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, Susanne Eyrisch, 2011, Bioorganic & medicinal chemistry letters.

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, T. Gallagher, 2011, Bioorganic & medicinal chemistry letters.

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020, Journal of medicinal chemistry.

University of Dundee Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020 .

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017 .

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2022, European journal of medicinal chemistry.

Synthesis of highly-functionalised pyridines via hetero-Diels–Alder methodology: reaction of 3-siloxy-1-aza-1,3-butadienes with electron deficient acetylenes

Timothy E. Hurst, C. Moody, T. Hurst, 2006 .

Organolithium-induced alkylative ring opening of aziridines: synthesis of unsaturated amino alcohols and ethers.

J. Witherington, B. Štefane, D. M. Hodgson, 2006, The Journal of organic chemistry.

Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums.

J. Witherington, B. Štefane, D. M. Hodgson, 2004, Chemical communications.

The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

S. Dabbs, D. Davies, Christopher W. Barfoot, 2010 .

Asymmetric synthesis of the fully elaborated pyrrolidinone core of oxazolomycin A.

T. Donohoe, Timothy O'Riordan, M. Peifer, 2012, Organic letters.

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

A. Fosberry, M. Gwynn, B. Bax, 2010, Nature Structural &Molecular Biology.

Intramolecular Diels—Alder Reactions of α,β‐Unsaturated Oxime Ethers as 1‐Azadienes: Synthesis of [c]‐Fused Pyridines.

Timothy E. Hurst, C. Moody, T. Hurst, 2008 .

Organolithium-induced enantioselective alkylative double ring-opening of epoxides: synthesis of enantioenriched unsaturated amino alcohols

J. Witherington, D. M. Hodgson, C. Maxwell, 2004 .

Organolithium-induced synthesis of acyclic unsaturated amino alcohols from epoxides of dihydropyrroles and tetrahydropyridines

J. Witherington, D. M. Hodgson, T. Miles, 2003 .

Enantioselective alkylative double ring opening of epoxides: synthesis of enantioenriched unsaturated diols and amino alcohols.

J. Witherington, D. M. Hodgson, F. Wilson, 2002, Angewandte Chemie.

Flexible palladium-catalysed amidation reactions for the synthesis of complex aryl amides

S. Dabbs, D. Davies, R. Markwell, 2010 .

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

Juan A. Bueren-Calabuig, I. Gilbert, A. Fairlamb, 2020, ACS infectious diseases.

The design of efficient and selective routes to a key 1,4-cis-substituted cyclohexylamide intermediate

D. Davies, M. McGuire, R. Markwell, 2010 .

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2021, Journal of medicinal chemistry.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Juan A. Bueren-Calabuig, David W. Gray, Frederick R. C. Simeons, 2019, Proceedings of the National Academy of Sciences.

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

David W. Gray, A. Hill, G. Drewes, 2018, Journal of medicinal chemistry.

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017, Journal of medicinal chemistry.

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

David W. Gray, D. Gray, S. Brough, 2016, PLoS neglected tropical diseases.

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

S. Norval, I. Gilbert, A. Fairlamb, 2018, Antimicrobial Agents and Chemotherapy.

University of Dundee Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

S. Norval, I. Gilbert, A. Fairlamb, 2018 .

Setting Our Sights on Infectious Diseases

John P. Overington, P. Herrling, J. McCarthy, 2019, ACS infectious diseases.

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Michael D. Urbaniak, G. Drewes, Markus Boesche, 2018, Nature.

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2023, Journal of medicinal chemistry.

Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2023, Nature.

Setting Our Sights on Infectious Diseases

John P. Overington, P. Herrling, J. McCarthy, 2019, ACS infectious diseases.

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0md00203h

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020, RSC medicinal chemistry.

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2018, Nature.